The role of cytolethal distending toxin in Glaesserella parasuis JS0135 strain infection: Cytotoxicity, phagocytic resistance and pathogenicity.

Glaesserella parasuis is an important porcine pathogen that commonly colonizes the upper respiratory tract of pigs and is prone to causing Glässer's disease under complex conditions. As yet, the disease has led to serious economic losses to the swine industry worldwide. Studies so far have found that several virulence factors are associated with the pathogenicity of G.

LRRC8A promotes cytolethal distending toxin-induced p53-dependent apoptosis in NPTr cells.

is an early colonizer of the swine upper respiratory tract and can break through the respiratory barrier for further invasion. However, the mechanisms underlying increases epithelial barrier permeability remain unclear. This study demonstrates that cytolethal distending toxin (CDT) induces p53-dependent apoptosis in new-born piglet tracheal (NPTr) cells.

QseBC two-component system senses epinephrine and regulates expression.

The key bacterial pathogen , which can cause Glässer's disease, has caused significant financial losses to the swine industry worldwide. Capsular polysaccharide (CPS) is an important virulence factor for bacteria, providing the ability to avoid recognition and killing by the host immune system. Exploring the alteration of CPS synthesis in in response to epinephrine stimulation can lay the groundwork for revealing the pathogenic mechanism of as well as providing ideas for Glässer's disease control.

HtrA is involved in stress response and adhesion in Glaesserella parasuis serovar 5 strain Nagasaki.

Glaesserella parasuis is an important pathogen that causes fibrinous polyserositis, peritonitis and meningitis in pigs, leading to considerable economic losses to the swine industry worldwide. It is well established that the serine protease HtrA is closely associated with bacterial virulence, but the role of HtrA in G. parasuis pathogenesis remains largely unknown.

autotransporters EspP1 and EspP2 are novel IgA-specific proteases.

Background: causes Glässer's disease, which is associated with severe polyarthritis, fibrinous polyserositis and meningitis, and leads to significant economic losses to the swine industry worldwide. IgA is one of the most important humoral immune factors present on mucosal surfaces, and it plays a crucial role in neutralizing and removing pathogens. is able to colonize the mucosal membrane of respiratory tract without being eliminated.