Insights From a Novel Splicing Variant and Recurrent Arginine Variants in the CHD3 Gene Causing Snijders Blok-Campeau Syndrome.

Snijders Blok-Campeau syndrome (SNIBCPS, OMIM#618205) is an autosomal dominant neurodevelopmental disorder attributed to pathogenic variants in the chromodomain helicase DNA binding protein 3 (CHD3) gene. To date, more than 100 individuals have been diagnosed with SNIBCPS. The syndrome is characterized by intellectual disability, global developmental delay, speech or language impediments, and dysmorphic features associated with macrocephaly.

New Genus and Species of Webspinners (Insecta: Embioptera) from the Mid-Cretaceous of Myanmar with a Catalog of Fossil Members.

One new genus ( gen. nov.) and three new species of webspinners ( gen.

Urchin-Like Mesoporous TiN Hollow Sphere Enabling Promoted Electrochemical Kinetics of Bromine-Based Flow Batteries.

Bromine-based flow batteries (BFB) have always suffered from poor kinetics due to the sluggish Br /Br redox, hindering their practical applications. Developing cathode materials with high catalytic activity is critical to address this challenge. Herein, the in-depth investigation for the free energy of the bromine redox electrode is conducted initially through DFT calculations, establishing the posterior desorption during oxidation as the rate-determining step.

NBR1-dependent autophagy activation protects against environmental cadmium-evoked placental trophoblast senescence.

Cadmium (Cd), a well-established developmental toxicant, accumulates in the placentae and disrupts its structure and function. Population study found adverse pregnancy outcomes caused by environmental Cd exposure associated with cell senescence. However, the role of autophagy activation in Cd-induced placental cell senescence and its reciprocal mechanisms are unknown.

One New Genus and Four New Species of Beaded Lacewings (Neuroptera: Berothidae) from Upper Cretaceous Myanmar Amber.

In recent years, as more and more fossil species of berothids from Myanmar have been reported, the species and morphological diversity of Berothidae continues to increase. Herein, one new species of Berothidae, sp. nov.

Targeted inhibition of biogenic amine-producing strains by spice extracts and control of biogenic amine accumulation in reduced-salt dry sausages.

This study aimed to screen spice extracts that can target the inhibition of biogenic amine (BA)-producing bacteria and reduce the BA accumulation in reduced-salt dry sausages. A total of 59 bacterial strains were isolated from reduced-salt dry sausages; among them, three isolates, namely, Staphylococcus epidermidis S1, S. saprophyticus S2, and S.

Plasmon-enhanced second harmonic generation of metal nanostructures.

As the most common nonlinear optical process, second harmonic generation (SHG) has important application value in the field of nanophotonics. With the rapid development of metal nanomaterial processing and chemical preparation technology, various structures based on metal nanoparticles have been used to achieve the enhancement and modulation of SHG. In the field of nonlinear optics, plasmonic metal nanostructures have become potential candidates for nonlinear optoelectronic devices because of their highly adjustable physical characteristics.

Uniform spike trains in optically injected quantum cascade oscillators.

It has been experimentally and theoretically analyzed that noise-induced excitability in quantum well and quantum dot semiconductor laser systems usually produces sharp spike patterns of non-uniform amplitude. In this paper, we experimentally record that a quantum cascade oscillator injected externally with a monochromatic laser beam exhibits a series of highly uniform spike trains, which occur in the proximity of the saddle-node bifurcation. Theoretical analysis based on a properly designed single-mode rate equation model endowed with quantum noise reveals that this high uniformity has its primary origin in the ultrashort carrier lifetime of the quantum cascade laser gain medium that is typically close to 1 ps.

In-context operator learning with data prompts for differential equation problems.

This paper introduces the paradigm of "in-context operator learning" and the corresponding model "In-Context Operator Networks" to simultaneously learn operators from the prompted data and apply it to new questions during the inference stage, without any weight update. Existing methods are limited to using a neural network to approximate a specific equation solution or a specific operator, requiring retraining when switching to a new problem with different equations. By training a single neural network as an operator learner, rather than a solution/operator approximator, we can not only get rid of retraining (even fine-tuning) the neural network for new problems but also leverage the commonalities shared across operators so that only a few examples in the prompt are needed when learning a new operator.

Analysis of biogenic amine in dry sausages collected from northeast China: From the perspective of free amino acid profile and bacterial community composition.

This study aimed to investigate the biogenic amines (BAs) in dry sausages collected from different regions in northeast China; explore the potential correlation amongst BAs, free amino acids (FAAs) and bacterial communities; and determine the key bacteria that produced or inhibited BAs. The contents of BAs significantly differed amongst various dry sausages. The dominating BAs were putrescine and spermine.

CD19CD24CD38 regulatory B cells deficiency revealed severity and poor prognosis in patients with sepsis.

Background: Sepsis still remains a major challenge in intensive care medicine with unacceptably high mortality among patients with septic shock. Due to current limitations of human CD19CD24CD38 Breg cells (Bregs) studies among sepsis, here, we tried to evaluate Bregs in severity and prognostic value in patients with sepsis.

Methods: Peripheral blood from 58 patients with sepsis and 22 healthy controls was analyzed using flow cytometry to evaluate the frequency and number of Bregs.

Confocal Laser Scanning Microscopy Based on a Silicon Photomultiplier for Multicolor In Vivo Imaging in Near-Infrared Regions I and II.

Confocal laser scanning microscopy (CLSM) is expected to exhibit a better imaging performance in the second near-infrared (NIR-II) windows with weak tissue scattering and autofluorescence. However, the indium gallium arsenide (InGaAs) detectors currently used for imaging in the NIR-II region are prohibitively expensive, hampering its extensive biomedical applications. In this study, a novel NIR-II CLSM system is developed by using the inexpensive silicon photomultiplier (SiPM) that can perform the multicolor biological imaging in vivo.

Mean field control problems for vaccine distribution.

With the invention of the COVID-19 vaccine, shipping and distributing are crucial in controlling the pandemic. In this paper, we build a mean-field variational problem in a spatial domain, which controls the propagation of pandemics by the optimal transportation strategy of vaccine distribution. Here, we integrate the vaccine distribution into the mean-field SIR model designed in Lee W, Liu S, Tembine H, Li W, Osher S (2020) Controlling propagation of epidemics via mean-field games.

Insight into enhanced acetic acid production from food waste in anaerobic hydrolysis/acidification with FeO supplementation.

FeO supplementation has been reported as a high-efficient approach to enhance biogas production in anaerobic digestion (AD). Volatile fatty acids (VFAs), especially acetic acid (HAc), are considered as important products in acidification process of AD. However, the possible mechanisms involved in promotion effect of FeO on HAc production in hydrolysis and acidification processes of AD have not been comprehensively studied.

The Influence of Entrepreneurship on the Innovation Path of Cultural Enterprises Under the Background of Digital Transformation.

This study aims to explore the impact mechanism of the new dimension of entrepreneurship on the innovation performance of enterprises in the context of digital transformation. The relationship between entrepreneurship and enterprise innovation performance is studied in Beijing, Shanghai, Guangzhou, Shenzhen, and other high-tech enterprises represented by innovative companies. Firstly, the correlation hypothesis between variables is proposed through the induction and summary of relevant data and academic achievements.

B cell subsets were associated with prognosis in elderly patients with community acquired pneumonia.

Background: The role of B cell subsets remained to be elucidated in a variety of immune diseases, though which was used as an effective biomarker for anti-inflammatory or antiviral response. This study aimed to evaluate the early changes of B cell subtypes distribution in elderly patients with community acquired pneumonia (CAP), as well as the association between B cell subtypes and prognosis.

Methods: This prospective study included elderly patients with CAP, severe CAP (sCAP) and healthy elderly subjects between April 2016 and March 2018.

A Survey of Stochastic Computing Neural Networks for Machine Learning Applications.

Neural networks (NNs) are effective machine learning models that require significant hardware and energy consumption in their computing process. To implement NNs, stochastic computing (SC) has been proposed to achieve a tradeoff between hardware efficiency and computing performance. In an SC NN, hardware requirements and power consumption are significantly reduced by moderately sacrificing the inference accuracy and computation speed.

[Expression and significance of β-catenin and NF-κB signaling pathway in knee osteoarthritis synovial inflammation].

Objective: To explore expression of β-catenin and NF-κB signaling pathway in synovial tissue of rats with different degrees of knee osteoarthritis (KOA).

Methods: Forty-eight SPF male rats weighed (200±20) g were randomly divided into three groups, namely model group (32 rats), sham operation group (8 rats) and control group (8 rats). KOA model rats were established by Hulth method, and 8 rats were killed at 2, 4, 8, 12 weeks respectively after modeling, in order to establish KOA model rats with moderate, early, mild and severe degree.

[Study on musculuskeletal ultrasound features and correlation of knee osteoarthritis].

Objective: To compare the correlation between musculoskeletal ultrasound features, dysfunction and X-ray findings in patients with knee osteoarthritis, and to analyze the pathological mechanism of soft tissue inflammation in knee osteoarthritis.

Methods: Cross-sectional method was performed in this research (Evidence level: III). The patients with knee osteoarthritis were collected according to the screening criteria from September 2016 to January 2017 in Orthopedic clinic in our hospital.

[Correlation of genes expression on MyD 88-dependent signaling pathway in progression of knee osteoarthritis].

Objective: To investigate expression features and correlation of genes expression on MyD88-dependent signaling pathway in synovial membrane (SM) of progression of knee osteoarthritis (OA).

Methods: Sixty Wistar rats were randomly divided into 6 groups, including blank group (N), false surgical group, model groups[2 weeks (2W), 4 weeks (4W), 8 weeks (8W) and 12 weeks (12W)], with 10 rats in each group. The models were established by using Hulth method.

[Case-control study on clinical effects of squeezing and clapping manipulation for treating the postpartum pubic symphysis separation].

Objective: To study the clinical effect of squeezing and clapping bone setting manipulation in treating the postpartum pubis symphysis separation.

Methods: From June 2015 to March 2017, 80 patients with postpartum pubic symphysis separation were randomly divided into treatment group and control group, 40 patients in each group. In treatment group, the patients' reproductive age ranged from 26 to 40 years old with an average of (30.

An eFTD-VP framework for efficiently generating patient-specific anatomically detailed facial soft tissue FE mesh for craniomaxillofacial surgery simulation.

Accurate surgical planning and prediction of craniomaxillofacial surgery outcome requires simulation of soft tissue changes following osteotomy. This can only be achieved by using an anatomically detailed facial soft tissue model. The current state-of-the-art of model generation is not appropriate to clinical applications due to the time-intensive nature of manual segmentation and volumetric mesh generation.

Iron oxide-mediated semiconductor photocatalysis vs. heterogeneous photo-Fenton treatment of viruses in wastewater. Impact of the oxide particle size.

The photo-Fenton process is recognized as a promising technique towards microorganism disinfection in wastewater, but its efficiency is hampered at near-neutral pH operating values. In this work, we overcome these obstacles by using the heterogeneous photo-Fenton process as the default disinfecting technique, targeting MS2 coliphage in wastewater. The use of low concentrations of iron oxides in wastewater without HO (wüstite, maghemite, magnetite) has demonstrated limited semiconductor-mediated MS2 inactivation.

A clinically validated prediction method for facial soft-tissue changes following double-jaw surgery.

Purpose: It is clinically important to accurately predict facial soft-tissue changes prior to orthognathic surgery. However, the current simulation methods are problematic, especially in anatomic regions of clinical significance, e.g.