Publications by authors named "Siti Umi Fairuz Azmi"
Article Synopsis
- The study investigates the prevalence of the HLA-B*58:01 allele, which is linked to severe skin reactions from allopurinol, among gout patients in Malaysia's multiethnic population.
- A total of 547 patients from Malay, Chinese, and Indian backgrounds were tested, revealing an overall allele prevalence of 16.8%, with the highest at 21.8% in Chinese patients.
- Notably, despite having the HLA-B*58:01 allele, none of the patients who used allopurinol developed severe cutaneous reactions, indicating the need for a better predictive model for these reactions.
Introduction: Allopurinol, the first-line treatment for chronic gout, is a common causative drug for severe cutaneous adverse reactions (SCAR). HLA-B*58:01 allele was strongly associated with allopurinol-induced SCAR in Asian countries such as Taiwan, Japan, Thailand and Malaysia. HLA-B*58:01 screening before allopurinol initiation is conditionally recommended in the Southeast-Asian population, but the uptake of this screening is slow in primary care settings, including Malaysia.
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