Publications by authors named "Siti Shuhada Mokhtar"
Low mineralization activity by human osteoblast cells (HOBs) indicates abnormal bone remodeling that potentially leads to osteoporosis. Oxidation, the most prominent form of high-density lipoprotein (HDL) modification, is suggested to affect bone mineralization through the inflammatory pathway. Adiponectin, which possesses anti-inflammatory activity, is postulated to have the ability to suppress the detrimental effects of oxidized HDL (oxHDL).
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- Tropical indigenous peoples in Asia (TIA) possess unique genetic distinctions despite significant intergroup variations, revealing a shared ancestral lineage known as basal Asian ancestry (bASN) that traces back approximately 50,000 years.
- This ancient ancestry contributes to specific adaptations related to hair and bone morphology, as well as pigmentation traits in TIA populations.
- The study highlights the initial human migrations into Asia and how genetic factors, including natural selection and new mutations, have influenced the observable traits in TIA cultures today.
Objectives: To determine the prevalence of metabolic syndrome (MS), ascertain the status of coronary risk biomarkers and establish the independent predictors of these biomarkers among the Negritos.
Settings: Health screening programme conducted in three inland settlements in the east coast of Malaysia and Peninsular Malaysia.
Subjects: 150 Negritos who were still living in three inland settlements in the east coast of Malaysia and 1227 Malays in Peninsular Malaysia.
Copy number variations (CNVs) are genomic structural variations that result from the deletion or duplication of large genomic segments. The characterization of CNVs is largely underrepresented, particularly those of indigenous populations, such as the Orang Asli in Peninsular Malaysia. In the present study, we first characterized the genome-wide CNVs of four major native populations from Peninsular Malaysia, including the Malays and three Orang Asli populations; namely, Proto-Malay, Senoi, and Negrito (collectively called PM).
View Article and Find Full Text PDFSoutheast Asia (SEA) is enriched with a complex history of peopling. Malaysia, which is located at the crossroads of SEA, has been recognized as one of the hubs for early human migration. To unravel the genomic complexity of the native inhabitants of Malaysia, we sequenced 12 samples from 3 indigenous populations from Peninsular Malaysia and 4 native populations from North Borneo to a high coverage of 28-37×.
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- CNV (copy number variation) is a significant factor in human genome diversity, influencing traits and being linked to various diseases.
- This study examines CNVs in 34 Negrito genomes from Peninsular Malaysia, uncovering 48 novel CNVs unique to this population.
- The research suggests that these CNVs may reflect recent local adaptations due to the Negritos' small population size and semi-nomadic lifestyle, with implications for understanding immune response and metabolic processes.
Article Synopsis
- Peninsular Malaysia played a key role in early human migrations, yet the genetic diversity and history of its indigenous populations remain largely unclear.
- A genome-wide study of four major Malaysian ethnic groups revealed that while Peninsular Malaysia shows high genetic diversity, indigenous groups (Orang Asli) are more isolated with less genetic diversity compared to European and East Asian populations.
- The research indicates that although these groups share common ancestry with other Asian populations, there are signs of recent gene flow from non-Asians, and natural selection has influenced certain traits related to health and physical characteristics.