Publications by authors named "Siti B Kresno"
Article Synopsis
- Despite advancements in lung cancer treatment, many cases are diagnosed late, and biomarkers like microRNA10b (miR-10b), suPAR, and PAI-1 show potential for assessing disease progression and treatment response in advanced non-small cell lung cancer (NSCLC).
- A study involving 40 advanced stage NSCLC patients revealed that high levels of miR-10b may be protective against disease progression, while elevated suPAR levels served as a risk factor for worse outcomes, and increased PAI-1 levels indicated a protective effect against poor treatment response.
- Ultimately, the results highlighted suPAR as a significant independent risk factor for the progression and poor response in NSCLC, while miR-10b was not reliable
Background: Cytopenia is the primary feature of Myelodysplastic Syndrome, even in the presence of hypercellular bone marrow. TNFα is recognized as both a proinflammatory, and proapoptotic cytokine with a well established role in promoting apoptosis in MDS. Therefore, TNFα has the potential to be a valuable biomarker for predicting the progression of cytopenia in MDS.
View Article and Find Full Text PDFObjective: This study aims to evaluate the correlation between electrolytes and serial miRNAs from our previous study. We want to prove that there is the molecular basis that underlying electrolytes disturbances as the predictive indicator to the outcome in NSCLC patients.
Results: There were positive correlation between potassium level with miR-34 (p = 0.
Background: Cytopenia is the primary phenomenon in myelodysplastic syndrome (MDS) amidst hypercellular bone marrow. The soluble CD40 ligand (sCD40L) is considered as a cytokine that can trigger synthesis of tumor necrosis factor α (TNFα) that promotes apoptosis. The objective of this study is to prove that recombinant human sCD40L (rh-sCD40L) exposure on bone marrow mononuclear cells (BMMC) MDS increases TNFα expression at mRNA level and at protein level.
View Article and Find Full Text PDFBackground: Th17 cells, a subset of CD4+ T cells with the capacity to produce IL-17, were reported to have pro-tumor and anti-tumor effects. Th1 cells are known for their capacity to eliminate tumor cells by producing IFN-γ. Transarterial chemoembolization (TACE) is a treatment of choice for patients with unresectable hepatocellular carcinoma (HCC).
View Article and Find Full Text PDFAim: To compare the expression of VEGF-A and desmoplastic reaction of colorectal cancer between the young aged and old aged patients excluding the stage of tumor.
Methods: Our study was a retrospective study on VEGF-A expression and desmoplastic reaction in pathology anatomy specimens of patients with colorectal cancer at young age (less than 40 years of age) and older age (more than equal 60 years of age). The samples had been taken since 2001 until 2008 and the sample size for each group was 42 samples for young age and 36 samples for older age subjects.
Aim: to evaluate the effects of curcumin on total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride in acute coronary syndrome patients.
Methods: this study were conducted at Dr. Cipto Mangunkusumo General Hospital (RSUPN-CM), Persahabatan Hospital, MMC Hospital and Medistra Hospital, Jakarta.
Aim: this study aimed to observe whether the interleukin-6 level in acute coronary syndrome (ACS) patients were higher than those in coronary heart disease (CHD) patients. In addition, we would like to observe the cut off point of interleukin-6 level in ACS.
Methods: this cross sectional study were conducted at Dr.