Publications by authors named "Site Li"

Poor wound healing and pathological healing have been pressing issues in recent years, as they impact human quality of life and pose risks of long-term complications. The study of neovascularization has emerged as a prominent research focus to address these problems. During the process of repair and regeneration, the establishment of a new vascular system is an indispensable stage for complete healing.

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The emergence of ligand-protected, atomically precise gold nanoclusters (NCs) in recent years has attracted broad interest in catalysis due to their well-defined atomic structures and intriguing properties. Especially, the precise formulas of NCs provide an opportunity to study the size effects at the atomic level without complications by the polydispersity in conventional nanoparticles that obscures the relationship between the size/structure and properties. Herein, we summarize the catalytic size effects of atomically precise, thioate-protected gold NCs in the range of tens to hundreds of metal atoms.

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Human epidermal growth factor receptor 2 (HER2) possesses tyrosine kinase activity and participates in cell growth, differentiation and migration, and survival. Its alterations, mainly including mutations, amplifications, and overexpression are associated with poor prognosis and are one of the major drivers in non-small cell lung cancer (NSCLC). Several clinical trials had been investigating on the treatments of HER2-altered NSCLC, including conventional chemotherapy, programmed death 1 (PD-1) inhibitors, tyrosine kinase inhibitors (TKIs) and antibody-drug conjugates (ADCs), however, the results were either disappointing or encouraging, but inconsistent.

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This work investigates the critical factors impacting electrochemical CO reduction reaction (CO RR) using atomically precise Au nanoclusters (NCs) as electrocatalysts. First, the influence of size on CO RR is studied by precisely controlling NC size in the 1-2.5 nm regime.

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Understanding the electron-phonon interaction in Au nanoclusters (NCs) is essential for enhancing and tuning their photoluminescence (PL) properties. Among all the methods, ligand engineering is the most straightforward and facile one to design Au NCs with the desired PL properties. However, a systematic understanding of the ligand effects toward electron-phonon interactions in Au NCs is still missing.

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Article Synopsis
  • Accurate prediction of distant metastasis in Nasopharyngeal Carcinoma (NPC) patients using pre-treatment MRI can lead to better treatment planning for high-risk individuals.
  • A Convolutional Neural Network (CNN) model was developed and tested using data from 441 NPC patients who received treatment at a hospital in China, utilizing segmented MR images for analysis.
  • The CNN model demonstrated superior performance compared to the traditional Tumour-Node-Metastasis staging system, particularly with the Cervical Metastatic Lymph Node dataset, achieving an average area under the curve (AUC) of 0.88.
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Neonatal repetitive noxious stimuli (RNS) has been shown to cause long-term harmful effects on nociceptive processing, learning, and memory which persist until adulthood. Plasticity-related gene 1 (PRG-1) regulates synaptic plasticity and functional reorganization in the brain during neuronal development. In this study, neonatal RNS rats were established by repetitive needle pricks to neonatal rats on all four feet to model repetitive pain exposure in infants.

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The latest development of neuroscience has deepened the understanding of the information-processing mechanisms in the human brain and inspired a couple of sophisticated computational methods, such as deep learning, memory networks, and hierarchical temporal memory. However, it remains a challenge to explore simpler models due to the high computational cost of the above-mentioned methods. This paper proposes recall network (RN), an intuitive and simple model, that initializes itself by constructing the network path derived from the correlation of features in the training dataset and then makes classification decisions by recalling the paths that are relevant to the features in the test set.

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There has been a growing interest in unsupervised domain adaptation (UDA) to alleviate the data scalability issue, while the existing works usually focus on classifying independently discrete labels. However, in many tasks (e.g.

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Mechanochemistry has been studied for some time, but research on the reactivity of charges exchanged by contact-electrification (CE) during mechanical stimulation remains scarce. Here, we demonstrate that electrons transferred during the CE between pristine dielectric powders and water can be utilized to directly catalyze reactions without the use of conventional catalysts. Specifically, frequent CE at Fluorinated Ethylene Propylene (FEP) - water interface induces electron-exchanges, thus forming reactive oxygen species for the degradation of an aqueous methyl orange solution.

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Macrophages are highly heterogeneous immune cells that fulfill tissue-specific functions. Tissue-derived signals play a critical role in determining macrophage heterogeneity. However, these signals remain largely unknown.

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Pain and depression, which tend to occur simultaneously and share some common neural circuits and neurotransmitters, are highly prevalent complication in patients with advanced cancer. Exploring the underlying mechanisms is the cornerstone to prevent the comorbidity of chronic pain and depression in cancer patients. Plasticity-related gene 1 (PRG-1) protein regulates synaptic plasticity and brain functional reorganization during neuronal development or after cerebral lesion.

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Electrocatalytic hydrogen evolution reaction (HER) holds promise in the renewable clean energy scheme. Crystalline Au and Ag are, however, poor in catalyzing HER, and the ligands on colloidal nanoparticles are generally another disadvantage. Herein, we report a thiolate (SR)-protected AuAg(SR) nanocluster with low coverage of ligands and a core composed of three icosahedral () units for catalyzing HER efficiently.

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Ligand effects are of major interest in catalytic reactions owing to their potential critical role in determining the reaction activity and selectivity. Herein, we report ligand effects in the CO2 electrochemical reduction reaction at the atomic level with three unique Au25 nanoclusters comprising the same kernel but different protecting ligands (-XR, where X = S or Se, and R represents the carbon tail). It is observed that a change in the carbon tail shows no obvious impact on the catalytic selectivity and activity, but the anchoring atom (X = S or Se) strongly affects the electrocatalytic selectivity.

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Thiolate-protected gold nanoclusters (NCs) are promising catalytic materials for the electrochemical CO reduction reaction (CO RR). In this work an atomic level modification of a Au NC is made by substituting two surface Au atoms with two Cd atoms, and it enhances the CO RR selectivity to 90-95 % at the applied potential between -0.5 to -0.

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Viruses, especially bacteriophages, are thought to have important functions in the deep-sea ecosystem, but little is known about the induction mechanism of benthic phages in response to environmental change. Our prior work characterized a cold-active filamentous phage SW1 that infects the deep-sea bacterium Shewanella piezotolerans WP3; however, the underlying mechanism of the putative thermo-regulated genetic switch of SW1 is still unclear. In this study, the DNA copy number and mRNA abundance of the deep-sea phage SW1 were quantified in the whole life cycle of its host S.

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Atomically precise nanoclusters of coinage metals in the 1-3 nm size regime have been intensively pursued in recent years. Such nanoclusters are attractive as they fill the gap between small molecules (<1 nm) and regular nanoparticles (>3 nm). This intermediate identity endows nanoclusters with unique physicochemical properties and provides nanochemists opportunities to understand the fundamental science of nanomaterials.

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Recent advances in the synthetic chemistry of atomically precise metal nanoclusters (NCs) have significantly broadened the accessible sizes and structures. Such particles are well defined and have intriguing properties, thus, they are attractive for catalysis. Especially, those NCs with identical size but different core (or surface) structure provide unique opportunities that allow the specific role of the core and the surface to be mapped out without complication by the size effect.

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Ultrasmall metal nanoparticles (often called nanoclusters) possess unique geometrical structures and novel functionalities that are not accessible in conventional nanoparticles. Recent progress in their synthesis and structural determination by X-ray crystallography has led to deep understanding of the structural evolution, structure-property correlation, and growth modes, such as the layer-by-layer growth in face-centered cubic (fcc)-type nanoclusters, linear assembly of vertex-shared icosahedral units, and other unique modes. The enriched knowledge on the correlation between the structure and the properties has rendered metal nanoclusters a new class of functional nanomaterials.

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Cancer is a complex disease: its pathology cannot be properly understood in terms of independent players-genes, proteins, molecular pathways, or their simple combinations. This is similar to many-body physics of a condensed phase that many important properties are not determined by a single atom or molecule. The rapidly accumulating large 'omics' data also require a new mechanistic and global underpinning to organize for rationalizing cancer complexity.

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Yolk-shell carbon encapsulated tin (Sn@C) eggette-like compounds (SCE) have been synthesized by a facile method. The SCE structures consist of tin cores covered by carbon membrane networks with extra voids between the carbon shell and tin cores. The novel nanoarchitectures exhibit high electrochemical performance in both lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs).

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Intratumor heterogeneity is a common phenomenon and impedes cancer therapy and research. Gastric cancer (GC) cells have generally been classified into two heterogeneous cellular phenotypes, the gastric and intestinal types, yet the mechanisms of maintaining two phenotypes and controlling phenotypic transition are largely unknown. A qualitative systematic framework, the endogenous molecular network hypothesis, has recently been proposed to understand cancer genesis and progression.

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Objective: To develop a method for simultaneous determination of hydrochlorothiazide, furosemide, clopamide, bumetanide and sibutramine hydrochloride in weight control foods with solid phase extraction-high performance liquid chromatography.

Methods: The analytes in the samples were extracted with 2% phosphoric acid-methanol (1:1, V/V) solution ultrasonically and centrifuged. The extracts were clean-up with Osis MCX SPE columns, concentrated under weak N2 stream, and reconstituted with 2% phosphoric acid-methanol (1:1, V/V) solution, vortex mixing and centrifugation at 12,000 r/min.

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Several novel series of C75 derivatives were synthesized and evaluated for their FAS inhibitory activities. The results showed compound 4-methylene-2-octyl-5-oxo-tetrahydro-thiophene-3-carboxylic acid (1c) had more effective FAS inhibitory (IC(50) was 2.56 microM and T.

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