The isolation of novel pregnane steroids from Miq. and the cytotoxicity against breast cancer cell lines (MCF-7).

Steroid groups isolated from many plants are known to play a significant role in various biological systems. Therefore, this research aimed to analyze two novel pregnane steroids, pachylenone A (1) and pachylenone B (2), isolated from Miq. The cytotoxicity of the steroids was evaluated against MCF-7 breast cancer cell lines with other known steroid compounds, namely 5α-dihydroprogesterone (3), GSD-8 (4), -5α-pregn-l7(20)-en-3,16-dion (5), 20β-hydroxy-5αH-pregnan-3-one (6), 3β-hydroxy-5α-pregnan-20-one (7), aglaiasterol B (8), and 2β,3β-dihydroxypregnan-16-one (9).

Phytochemistry and Biological Activities of Endophytic Fungi from the Meliaceae Family.

Meliaceae plants are found worldwide in tropical or subtropical climates. They are important ethnobotanically as sources of traditional medicine, with 575 species and 51 genera. Previous research found that microorganisms are plant pioneers to produce secondary metabolites with diverse compound structures and bioactivities.

Phytochemistry and Biological Activities of Genus (Meliaceae).

is one of the largest genera of the American Meliaceae family, consisting of over 69 species which are widely distributed in Mexico, Argentina, and Africa and are used in traditional medicine for several diseases. Previous studies reported that the species produce secondary metabolites such as sesquiterpenoid, diterpenoid, triterpenoid, limonoid, steroid, and aromatic compounds. The preliminary chemical investigation commenced by isolating the limonoid compound, dihydrogedunin, in 1962; then, 240 compounds were obtained from the isolation and hydrodistillation process.

Phytochemistry and biological activity of Lansium domesticum Corr. species: a review.

Objectives: This study aims to review and describe the ethnobotanical, phytochemical and biological activity of various extracts and compounds isolated from Lansium domesticum Corr. from 1967 to 2022 and to study the opportunities that can be developed in the future in the pharmaceutical and pharmacology fields. The related articles, followed by the classification of L.