Systematic transcriptome-wide analysis and validation of tributyltin-induced differential changes in the liver with sex-specific effects.

Background: Tributyltin (TBT), a prevalent environmental antiseptic, contaminates seafood, fish, and drinking water, posing health risks. While TBT's hepatic toxicity is well-known, its sex-specific effects on liver function remain poorly understood.

Methods: To address this gap, a comprehensive analysis was conducted utilizing the Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET) dataset.

Data Subdivision Based Dual-Weighted Robust Principal Component Analysis.

Principal Component Analysis (PCA) is one of the most important unsupervised dimensionality reduction algorithms, which uses squared -norm to make it very sensitive to outliers. Those improved versions based on -norm alleviate this problem, but they have other shortcomings, such as optimization difficulties or lack of rotational invariance, etc. Besides, existing methods only vaguely divide normal samples and outliers to improve robustness, but they ignore the fact that normal samples can be more specifically divided into positive samples and hard samples, which should have different contributions to the model because positive samples are more conducive to learning the projection matrix.

USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5.

: Glioblastoma (GBM) is the most aggressive type of primary brain cancer and contains self-renewing GBM stem cells (GSCs) that contribute to tumor growth and therapeutic resistance. However, molecular determinants governing therapeutic resistance of GSCs are poorly understood. : We performed genome-wide analysis of deubiquitylating enzymes (DUBs) in patient-derived GSCs and used gene-specific shRNAs to identify an important DUB gene contributing to GSC survival and radioresistance.

Investigating the role of IDO1 in tumors: correlating IDO1 expression with clinical pathological features and prognosis in lung adenocarcinoma patients.

Purpose: This study aimed to investigate the role and expression patterns of IDO1 in various tumors, focusing on its correlation with clinical pathological characteristics and prognosis in patients specifically diagnosed with lung adenocarcinoma.

Methods: Pan-cancer analysis assessed IDO1 function across different tumor types. Bioinformatics tools, immunohistochemistry techniques, and statistical analyses were employed to evaluate IDO1 expression levels and their association with clinical pathological features and prognosis in patients with lung adenocarcinoma.

Progress and prospects of elastography techniques in the evaluation of fibrosis in chronic liver disease.

The precise assessment of liver fibrosis degree is imperative for monitoring and managing chronic liver diseases. Traditionally, liver biopsy and quantitative blood biomarkers have been the mainstays for fibrosis assessment, albeit each with its inherent limitations. However, the emergence of elastography presents a promising non-invasive alternative, potentially supplanting or complementing traditional biomarkers.

Molecular contacts with an orthogonal π-skeleton induce amorphization to enhance perovskite solar cell performance.

Perovskite solar cells represent a promising class of photovoltaics that have achieved exceptional levels of performance within a short time. Such high efficiencies often depend on the use of molecule-based selective contacts that form highly ordered molecular assemblies. Although this high degree of ordering usually benefits charge-carrier transport, it is disrupted by structure deformation and phase transformation when subjected to external stresses, which limits the long-term operational stability of perovskite solar cells.

Expression levels of STAT3, and protein levels of IL‑6 and sPD‑L1 in different pathological characteristics of endometrial adenocarcinomas.

Endometrial cancer is a common type of cancer in women, with endometrial adenocarcinoma (EA) being the most common type. Monitoring the expression levels of signal transducer and activator of transcription 3 (STAT3), the protein levels of interleukin 6 (IL-6) and soluble programmed death ligand 1 (sPD-L1), and their differences in patients with various pathological characteristics is beneficial for accurately evaluating the disease stage and differentiation degree of patients in clinical practice. The aim of the present study was to assess the expression levels of STAT3, and the protein levels of IL-6 and sPD-L1 in EA.

Predictive Value of Dynamic Changes in Inflammatory Markers Within 24 Hours After Mechanical Thrombectomy for Outcome in Patients with Acute Ischemic Stroke.

Background: This study analyzes the factors influencing the 90-day prognosis of acute ischemic stroke (AIS) patients after mechanical thrombectomy (MT) and established a multidimensional risk model to predict postoperative 90-day outcomes.

Methods: A retrospective analysis of clinical data was conducted for AIS patients who underwent MT at our hospital. A total of 111 patients who met the inclusion criteria were included in the study.

Selenocysteine-Activatable Near-Infrared Fluorescent Probe for Screening of Anti-inflammatory Components in Herbs.

Inflammation, a central process in numerous diseases, plays a crucial role in hepatic disorders, arthritis, cardiac conditions, and neurodegenerative ailments. Given the lack of effective anti-inflammatory drugs, it is imperative to assess inflammation severity and explore novel therapeutics. Selenocysteine (Sec), a key mediator of selenium's biological function, is closely involved in anti-inflammatory responses.

Midterm comparative result of absorbable screws and metal screws in pediatric medial humeral epicondyle fracture.

Backgroud: Medial humeral epicondyle fracture is a prevalent type of upper limb fractures in pediatric patients. This study aims to compare the follow-up clinical results and complications in 30 children with medial epicondyle fractures who were treated with either metal screws or absorbable screws at our hospital.

Methods: A retrospective review was conducted on 30 children with medial humeral epicondyle fractures, who were divided into two groups: Metal group (18 children) underwent fixation using metal screws, while Absorbable group (12 children) received absorbable screws between January 2016 and June 2024.

Revolutionizing nanozymes: The synthesis, enzyme-mimicking capabilities of carbon dots, and advancements in catalytic mechanisms.

Nanozymes, a revolutionary category of engineered artificial enzymes based on nanomaterials, have been developed to overcome the inherent limitations of natural enzymes, such as the high cost associated with storage and their fragility. Carbon dots (CDs) have emerged as compelling candidates for various applications due to their versatile properties. Particularly noteworthy are CDs with a range of surface functional groups that exhibit enzyme-like behavior, combining exceptional performance with catalytic capabilities.

Bibliometric analysis of global research on vitamins and cancer between 2003 and 2022.

Background: Vitamins are essential nutrients that play an indispensable role in maintaining the vital functions of the human body. A growing number of studies have shown a link between vitamins and cancer. However, there is no systematic review and bibliometric analysis in this field.

Modifying effects of prenatal exposure to rare earth elements on birth outcomes through maternal thyroid function in early pregnancy.

The potential health effects of exposure to rare earth elements (REEs) remain largely unexplored. This prospective cohort study aimed to elucidate the association between early pregnancy REE exposure and maternal thyroid function, as well as neonatal birth outcomes, in a cohort of pregnant women in Beijing, China. Additionally, the study explored the mediating role of thyroid homeostasis in the effects of REE exposure.

DKN-01 Suppresses Gastric Cancer Progression Through Activating cGAS-STING Pathway to Block Macrophage M2 Polarization.

Dickkopf-1 (DKK1) is a secretory antagonist that can bind with the Wnt coreceptor to desensitize cells to canonical Wnt ligands. DKN-01 is a specific antibody targeting secreted DKK1, which has been investigated as a monotherapy or combination therapy for various malignant tumors, including gastric cancer (GC). Tumor-associated macrophages (TAMs) with high plasticity usually present M2 phenotype, which can promote tumor progression.

Resveratrol promotes diabetic wound healing by inhibiting ferroptosis in vascular endothelial cells.

Background: Diabetic wounds are a common complication of diabetes, with alarming disability and mortality rates. Ferroptosis plays an essential role in the occurrence and development of diabetes mellitus and its complications, suggesting that mitigating ferroptosis can be used as a potential therapeutic strategy. Resveratrol (RSV) can promote the angiogenesis of diabetic wounds, but its molecular mechanism is unclear, and RSV has a role in regulating ferroptosis.

Tremella aurantialba polysaccharides alleviate ulcerative colitis in mice by improving intestinal barrier via modulating gut microbiota and inhibiting ferroptosis.

We aimed to investigate the effect of a polysaccharide from Tremella aurantialba on ulcerative colitis (UC), which targets ferroptosis in epithelial cells. TA 2-1 (127 kDa) was isolated from T. aurantialba and consisted of Man, Xyl, GlcA, Glc, Fuc and Rha with a molar ratio of 59.

Efficacy and safety of ultrasound-guided radiofrequency ablation combined with transhepatic artery embolization chemotherapy for hepatocellular carcinoma: A meta-analysis.

Objective: Meta-analysis was used to assess the efficacy and safety of ultrasound-guided radiofrequency ablation combined with transhepatic artery embolization chemotherapy for hepatocellular carcinoma.

Methods: Randomized controlled studies on ultrasound-guided radiofrequency ablation combined with transhepatic artery embolization chemotherapy for hepatocellular carcinoma were searched in the databases of PubMed, Embase, Cochrane library, web of science with a search deadline of March 14, 2024. Data were analyzed using Stata 15.

Thalamocortical dysconnectivity is associated with pain in patients with knee osteoarthritis.

Previous studies have suggested that the morphology and function of the thalamus and cortex are abnormal in patients with knee osteoarthritis (KOA). However, whether the thalamocortical network is differentially affected in this disorder is unknown. In this study, we examined functional and effective connectivity between the thalamus and major divisions of the cortex in 27 healthy controls and 27 KOA patients using functional magnetic resonance imaging.

Optimization of the integrated green-gray-blue system to deal with urban flood under multi-objective decision-making.

The integrated green-gray-blue (IGGB) system is considered to be a new way of stormwater management, and a comprehensive evaluation of the green-gray-blue infrastructure layout mode under different return periods is the key to the implementation decision-making of stormwater management. In this study, a blue-green synergism evaluation model is established to optimize the layout of blue-green infrastructure. An evaluation framework combining the evaluation indicator system and the hydrology model is established.