IL-17A enhances the inflammatory response of glaucoma through Act1/TRAF6/NF-κB pathway.

Objectives: To investigate the possible roles of Interleukin 17A (IL-17A) and IL-17A neutralizing antibodies (IL-17Ab) in glaucoma and the potential mechanisms.

Methods: The two glaucoma animal models, chronic ocular hypertension (COH) and N-methyl-D-aspartate (NMDA)-induced retinal ganglion cell (RGC) damage, were established and treated with intravitreal injection of IL-17A or IL-17Ab. Intraocular pressure (IOP) was measured by a rebound tonometer.

Identification of immune-related biomarkers for glaucoma using gene expression profiling.

Glaucoma, a principal cause of irreversible vision loss, is characterized by intricate optic neuropathy involving significant immune mechanisms. This study seeks to elucidate the molecular and immune complexities of glaucoma, aiming to improve our understanding of its pathogenesis. Gene expression profiles from glaucoma patients were analyzed to identify immune-related differentially expressed genes (DEGs).

Activation of Sonic Hedgehog Signaling Pathway Regulates Human Trabecular Meshwork Cell Function.

To investigate the effects of Sonic hedgehog (Shh) signaling on primary human trabecular meshwork (HTM) cells. Primary HTM cells were isolated from healthy donors and cultured. Recombinant Shh (rShh) protein and cyclopamine were used to activate and inhibit the Shh signaling pathway, respectively.

The effect of diet and exercise on climacteric symptomatology.

Background And Objectives: This study aimed to explore the effects of health education, diet and exercise interventions on the climacteric symptoms of perimenopausal women.

Methods And Study Design: A total of 78 perimenopausal women in a gynaecological clinic from June 2018 to August 2018 were recruited and divided randomly into the following three groups: A (centralised education alone), B (health education + per-sonalised diet guidance) and C (health education + personalised diet guidance + intensive resistance exercise). The changes in diet score, exercise habits and climacteric symptoms were observed after 3 months.

Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling.

Dendritic cells (DCs) are the major antigen-presenting cells and play an important role in autoimmune uveitis. Emerging evidence suggests that bile acids (BAs) regulate DCs maturation. However, the underlying mechanisms by which BAs regulate the function of DCs still need to be clarified.

NEDD9 Mediates the FAK/Src Signaling Pathway to Promote the Adhesion of Human Trabecular Meshwork Cells after Dexamethasone Treatment.

Purpose: The differential gene expression of neural precursor cell expressed developmentally downregulated 9 (NEDD9) in human trabecular meshwork (HTM) cells after dexamethasone (Dex) treatment was confirmed through gene expression profiling. However, the regulatory mechanism of NEDD9 expression in HTM cells remains unknown. In this study, we investigated NEDD9 expression in HTM cells and gained a better understanding of glucocorticoid-induced glaucoma (GIG) pathophysiology.

Dietary and Exercise Interventions for Perimenopausal Women: A Health Status Impact Study.

Purpose: To explore the impact of different intervention methods on physical health indexes of perimenopausal women.

Methods: Seventy-eight perimenopausal women were divided into three groups. Group A received routine gynecological diagnosis and treatment and participated in centralized lifestyle health education.

Dietary and exercise interventions for metabolic health in perimenopausal women in Beijing.

Background And Objectives: This study aims to investigate the effects of individualised dietary guidance and anti-resistance exercise intervention on blood pressure and metabolic indexes of perimenopausal women.

Methods And Study Design: Between June 2018 to August 2018, 78 perimenopausal women were recruited at the Gynaecological Outpatient Department of Beijing Pinggu District Hospital. After coding, they were randomly divided into three groups, A, B and C, by lottery.

Ultrafast optical imaging at 2.0 μm through second-harmonic-generation-based time-stretch at 1.0 μm.

The performance of ultrafast time-stretch imaging at long wavelengths (beyond 1.5 μm) has suffered from low detection sensitivity due to the increasing loss of optical dispersive fibers. Here, we report an ultrafast optical imaging system with a line scan rate of ∼19  MHz at the 2.

Ultra-broadband spatiotemporal sweeping device for high-speed optical imaging.

In this work, we propose and demonstrate a spatiotemporal sweeping fiber bundle for ultra-fast optical diagnoses over a multioctave wavelength span, ranging from ∼400  nm to ∼2000  nm. This all-optical spatiotemporal sweeping is realized by precisely controlling the length increment between individual fibers in the fiber bundle. Here, a 200-ps pixel delay increment specifically enables a pixel readout rate of up to 5 GHz.

Flexible pulse-stretching for a swept source at 2.0 μm using free-space angular-chirp-enhanced delay.

Dispersive pulse-stretching at 2.0 μm has long been hindered by the high intrinsic optical loss from conventional dispersive media. Here a flexible pulse-stretching technique at 2.

Optical receiver sensitivity enhancement by single- and dual-band fiber optical parametric amplifier.

A semi-classical model is proposed theoretically and demonstrated experimentally on the optical receiver sensitivity enhancement by single-band (signal or idler) and dual-band (signal and idler) fiber optical parametric amplifier (FOPA). The sensitivity enhancement by single-band is determined by the gain of FOPA and the transmission loss of signal and idler, and it can be further improved by up to 3-dB using amplified signal and phase-conjugated idler together at dual-band configuration. The theoretical results are experimentally verified in both fiber communication and biomedical imaging applications.

High-speed wavelength-swept source at 2.0 μm and its application in imaging through a scattering medium.

We report a high-speed wavelength-swept source operating at 2.0 μm through advanced time-stretch technology. It sweeps over 30 nm at a speed of 3.

High-power widely tunable all-fiber thulium-assisted optical parametric oscillator at SWIR band.

A novel short-wave infrared (SWIR) all-fiber thulium-assisted optical parametric oscillator (TAOPO) that exploits jointly optical parametric conversion and thulium amplification in a highly nonlinear fiber (HNLF) and thulium-doped fiber (TDF) is demonstrated. This is implemented through constructing a joint fiber line by directly fusion splicing 50 m HNLF with 1.5 m TDF.

Sensitivity enhancement in swept-source optical coherence tomography by parametric balanced detector and amplifier.

We proposed a sensitivity enhancement method of the interference-based signal detection approach and applied it on a swept-source optical coherence tomography (SS-OCT) system through all-fiber optical parametric amplifier (FOPA) and parametric balanced detector (BD). The parametric BD was realized by combining the signal and phase conjugated idler band that was newly-generated through FOPA, and specifically by superimposing these two bands at a photodetector. The sensitivity enhancement by FOPA and parametric BD in SS-OCT were demonstrated experimentally.

Compact and stable temporally magnified tomography using a phase-locked broadband source.

The temporally magnified tomography system is further improved in terms of resolution and imaging stability. We simplify the system configuration and improve the axial resolution simultaneously by utilizing a stabilized all-fiber broadband source. The highly stable spectrum of the source assisted by a phase-locked loop guarantees an improved imaging quality.

110 nm versatile fiber optical parametric amplifier at 1.0 μm.

The fiber optical parametric amplifier (FOPA) has been well investigated and widely adopted at the telecommunication window, and outstanding progress has been achieved in areas such as high gain, wide bandwidths, and even flexible gain-spectrum shape. In contrast, a FOPA at the bio-favorable window, 1.0 μm, has been largely underexploited, especially for its relatively limited bandwidth.

109 MHz optical tomography using temporal magnification.

Ultrafast optical tomographic imaging with a 109 MHz A-scan rate is achieved by using temporal magnification. Based on two four-wave mixing (FWM) time lenses with carefully designed group delay dispersion, we construct a temporal imaging system with a magnification factor of 48.3×.

Experimental observation of optical differentiation and optical Hilbert transformation using a single SOI microdisk chip.

Optical differentiation and optical Hilbert transformation play important roles in communications, computing, information processing and signal analysis in optical domain offering huge bandwidth. Meanwhile, silicon-based photonic integrated circuit is one of the most promising candidates for all-optical signal processing due to its intrinsic advantages of low power consumption, compact footprint, ultra-high speed and compatibility with electronic integrated circuits. In this study, we analyze the interrelation between first-order optical differentiation and optical Hilbert transformation and then experimentally demonstrate a feasible integrated scheme which can simultaneously function as first-order optical differentiation and optical Hilbert transformation based on a single microdisk resonator.

High-order all-optical differential equation solver based on microring resonators.

We propose and experimentally demonstrate a feasible integrated scheme to solve all-optical differential equations using microring resonators (MRRs) that is capable of solving first- and second-order linear ordinary differential equations with different constant coefficients. Employing two cascaded MRRs with different radii, an excellent agreement between the numerical simulation and the experimental results is obtained. Due to the inherent merits of silicon-based devices for all-optical computing, such as low power consumption, small size, and high speed, this finding may motivate the development of integrated optical signal processors and further extend optical computing technologies.

All-optical computation system for solving differential equations based on optical intensity differentiator.

We propose and experimentally demonstrate an all-optical differentiator-based computation system used for solving constant-coefficient first-order linear ordinary differential equations. It consists of an all-optical intensity differentiator and a wavelength converter, both based on a semiconductor optical amplifier (SOA) and an optical filter (OF). The equation is solved for various values of the constant-coefficient and two considered input waveforms, namely, super-Gaussian and Gaussian signals.

Highly sensitive liquid-level sensor based on dual-wavelength double-ring fiber laser assisted by beat frequency interrogation.

A highly sensitive liquid-level sensor based on dual-wavelength single-longitudinal-mode fiber laser is proposed and demonstrated. The laser is formed by exploiting two parallel arranged phase-shift fiber Bragg gratings (ps-FBGs), acting as ultra-narrow bandwidth filters, into a double-ring resonators. By beating the dual-wavelength lasing output, a stable microwave signal with frequency stability better than 5 MHz is obtained.