HNF4α improves hepatocyte regeneration by upregulating PXR.

Hepatocyte nuclear factor 4 alpha (HNF4α) and the pregnane X receptor (PXR) are involved in hepatocyte regeneration. It is not clear whether HNF4α is involved in hepatocyte regeneration through the regulation of PXR. This study aims to explore the regulatory relationship between HNF4a and PXR, and whether it affects hepatocyte regeneration.

Correlation between microbial characteristics and reproductive status of the yak uterus based on macrogenomic analysis.

Introduction: This study aimed to investigate the microbial characteristics of yak uteri collected using intrauterine cotton swabs (CS) during different reproductive stages and the correlation of these microbial characteristics with reproductive status.

Methods: We used a macrogenomic approach to analyze the functional aspects of different microorganisms in samples collected during the pre-estrus, estrus, late estrus, and diestrus stages.

Results: The results revealed the presence of 1293 microbial genera and 3401 microbial species in the uteri of yaks at different reproductive stages.

Metagenomic analysis reveals a dynamic microbiome with diversified adaptive functions that respond to ovulation regulation in the mouse endometrium.

Understanding the microflora inhabiting the reproductive tract is important for a better understanding of female physiology and reproductive health. The endometrial fluid from mice in three reproductive stages (A: Unproductive mice; B: Postovulatory mice; C: Postpartum mice) was extracted for microbial DNA extraction and sequencing. Phenotypic and functional analyses of endometrial microbial enrichment was undertaken using LefSe.

Molybdenum Disulfide-Integrated Iron Organic Framework Hybrid Nanozyme-Based Aptasensor for Colorimetric Detection of Exosomes.

Tumor-derived exosomes are considered as a potential marker in liquid biopsy for malignant tumor screening. The development of a sensitive, specific, rapid, and cost-effective detection strategy for tumor-derived exosomes is still a challenge. Herein, a visualized and easy detection method for exosomes was established based on a molybdenum disulfide nanoflower decorated iron organic framework (MoS-MIL-101(Fe)) hybrid nanozyme-based CD63 aptamer sensor.

Dynamic Changes in Proteome during Yak Oocyte Maturation Analyzed Using iTRAQ Technology.

The aim of this study was to investigate protein regulation at different time points during the in vitro maturation of yak oocytes. Yak oocytes at GV, MI, and MII stages were collected during in vitro maturation, and differential proteomics sequencing was performed using iTRAQ technology. GO functional classification indicated that the differential proteins were closely associated with biological processes such as "metabolic processes", and molecular events such as "binding" molecular-function-related categories were active.

Endoplasmic Reticulum Stress and Mitochondrial Stress in Drug-Induced Liver Injury.

Drug-induced liver injury (DILI) is a widespread and harmful disease closely linked to mitochondrial and endoplasmic reticulum stress (ERS). Globally, severe drug-induced hepatitis, cirrhosis, and liver cancer are the primary causes of liver-related morbidity and mortality. A hallmark of DILI is ERS and changes in mitochondrial morphology and function, which increase the production of reactive oxygen species (ROS) in a vicious cycle of mutually reinforcing stress responses.

Efficient Photocatalytic Fuel Cell via Simultaneous Visible-Photoelectrocatalytic Degradation and Electricity Generation on a Porous Coral-like WO/W Photoelectrode.

Photocatalytic fuel cells (PFCs) have proven to be effective for generating electricity and degrading pollutants with a goal to resolve environmental and energy problems. However, the degradation of persistent organic pollutants (POPs), such as perfluorooctanoic acid (PFOA), remains challenging. In the present work, a porous coral-like WO/W (PCW) photoelectrode with a well-designed energy band structure was used for the photoelectrocatalytic degradation of POPs and the simultaneous generation of electricity.

Lack of Association between Genetic Polymorphisms of JAK-STAT Signaling Pathway Genes and Acute Anterior Uveitis in Han Chinese.

This study aimed to investigate the association between single nucleotide polymorphisms (SNPs) of JAK-STAT signaling pathway genes and acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS) in the Han Chinese population. . Eleven SNPs of the , , , , and genes were analyzed in 443 AAU patients with AS, 486 AAU patients without AS, and 714 healthy controls.