The gene is involved in Wharton's jelly derived mesenchymal stem cell treatment of Alzheimer's disease in rats.

Introduction: Our study aims to observe the effect of mesenchymal stem cells (MSCs) in lowering amyloid accumulation and ryanodine receptor 3 (RYR3) gene expression, further improving cognitive dysfunction in Alzheimer's disease (AD).

Methods: Twenty male adult Wistar rats were randomly distributed into three groups of animals ( = 5). The AlCl group was given 300 mg/kg body weight (BW) of AlCl intraperitoneally for 5 days, further the MSC injection, and their effect after 30 days was observed.