Publications by authors named "Siruan Chen"
Article Synopsis
- Kaempferol (KF), a key compound in safflower, has pharmacological benefits and is being studied for its potential to treat epilepsy, although its exact mechanisms are not yet understood.
- Network pharmacology revealed KF may influence calcium signaling pathways and neuronal excitability, while experiments on epileptic mice showed KF delayed seizures and protected against brain damage.
- The findings suggest KF’s anticonvulsant effects are linked to neuroprotection, reduced hyperexcitability, and calcium regulation, positioning it as a potential treatment for epilepsy.
Chelerythrine inhibits NR2B NMDA receptor independent of PKC activity.
Biochem Biophys Res Commun
December 2024
Article Synopsis
- - N-methyl-d-aspartate receptors (NMDARs) are key players in excitatory neurotransmission in the central nervous system and are linked to several neurological disorders, making them a target for potential therapies.
- - The study investigates the effects of chelerythrine (CHE), an alkaloid with various biological activities, on NMDAR function, revealing that CHE suppresses NMDA-induced currents in neurons and facilitates desensitization of GluN2B NMDARs.
- - The inhibitory action of CHE on GluN2B NMDARs is independent of protein kinase C activity and is influenced by pH, with specific interactions identified at the receptor's M3 α-helical
Background: Disorders of glutamate metabolism and excessive release participat in multiple neuronal pathologies including ischemic stroke (IS), Alzheimer's disease (AD), or Parkinson's disease (PD). Recently, herbal medicines have been widely used and have shown satisfactory results in the treatment of neurological disorders. Gastrodin is a traditional Chinese medicine (TCM) used for the treatment of nerve injuries, spinal cord injuries, and some central nervous system diseases as well.
View Article and Find Full Text PDFHyperalgesia resulting from sleep deprivation (SD) poses a significant a global public health challenge with limited treatment options. The nucleus accumbens (NAc) plays a crucial role in the modulation of pain and sleep, with its activity regulated by two distinct types of medium spiny neurons (MSNs) expressing dopamine 1 or dopamine 2 (D1-or D2) receptors (referred to as D1-MSNs and D2-MSNs, respectively). However, the specific involvement of the NAc in SD-induced hyperalgesia remains uncertain.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates Jujuboside B (JuB), a compound from the Ziziphi Spinosae Semen herb, for its neuroprotective effects against febrile seizures in children under five.
- - It was found that JuB significantly increased the time before seizures occurred and decreased their intensity in a mouse model, while also reducing the excitability of hippocampal neurons.
- - The mechanism of action involves inhibiting AMPA receptors, which leads to lower levels of calcium inside the neurons, ultimately helping to alleviate the seizures.
Ferric Chelate Reductase 1 Like (FRRS1L) protein has been identified as an auxiliary regulatory protein for the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR). FRRS1L is highly expressed in the cerebellum and other brain regions associated with the control of motor function. Loss of FRRS1L has been shown to lead to impaired synaptic transmission via AMPARs and to movement disorders.
View Article and Find Full Text PDFAttention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder prevalent in school-age children. At present, however, its etiologies and risk factors are unknown. Transmembrane α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor regulatory protein γ-8 (TARP γ-8, also known as calcium voltage-gated channel auxiliary subunit gamma 8 (CACNG8)) is an auxiliary AMPA receptor (AMPAR) subunit.
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