Publications by authors named "Sirria M El-Marhoumy"
Chronic toxoplasmosis which is positively correlated with many neuropsychiatric problems has no curative treatment till now; due to the resistant tissue cysts especially in the brain. In search of an effective treatment, guanabenz-loaded polyethylene glycol poly lactic-co-glycolic acid (PEG-PLGA) nanoparticles was evaluated against chronic experimental toxoplasmosis. For this purpose, each mouse was infected with 10 cysts of Toxoplasma gondii (ME 49 strain).
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- The study evaluated the effectiveness of an autoclaved cercarial vaccine (ACV) in protecting Swiss albino mice from Schistosoma mansoni infection by dividing them into a control group and several vaccinated groups.
- The vaccinated groups received different doses of the ACV, with the single 0.1 ml dose showing the best results in reducing infection levels.
- The findings indicated a significant decrease in adult worm numbers, liver and intestinal ova, and granuloma size, along with increased IL-10 mRNA expression in vaccinated mice compared to the control group.