Assessment of Hematological Toxicity of Adjuvant Chemotherapy in the Complex Therapy of Breast Cancer.

Within the framework of multicenter clinical studies of the original anticancer drug "Arglabin" in the complex therapy of breast cancer (BC) in an increased dose on the basis of the Regional Oncological Dispensary, Karaganda, 80 patients BC were examined and treated: 40 patients in the control group and 40 in the study group. The index of grade I anemia was higher in patients of the control group: in (15.6±6.

Material surfaces in stochastic flows: Integrals of motion and intermittency.

We consider the line, surface, and volume elements of fluid in stationary isotropic incompressible stochastic flow in d-dimensional space and investigate the long-time evolution of their statistic properties. We report the discovery of a family of d!-1 stochastical integrals of motion that are universal in the sense that their explicit form does not depend on the statistics of velocity. Only one of them has been discussed previously.

NiB-CrC Coatings Prepared by Magnetron Sputtering Using Composite Ceramic NiCr-BC Target Produced by Detonation Spray Coating.

A metal-ceramic composite target for magnetron sputtering was fabricated for the first time by a robotic complex for the detonation spraying of coatings equipped with a multi-chamber detonation accelerator. A mixture of metal and ceramic NiCr/BC powders was sprayed onto the copper base of the cylindrical composite target cathode. The study of the structure of a metal-ceramic composite coating target using scanning electron microscopy showed that the coating material is dense without visible pores; the elemental composition is evenly distributed in the material.

Long-term properties of finite-correlation-time isotropic stochastic systems.

We consider finite-dimensional systems of linear stochastic differential equations ∂_{t}x_{k}(t)=A_{kp}(t)x_{p}(t), A(t) being a stationary continuous statistically isotropic stochastic process with values in real d×d matrices. We suppose that the laws of A(t) satisfy the large-deviation principle. For these systems, we find exact expressions for the Lyapunov and generalized Lyapunov exponents and show that they are determined in a precise way only by the rate function of the diagonal elements of A.

Association of four genetic variants with colorectal cancer in Kazakhstan population.

The study was conducted to search for polymorphisms located in the 10th chromosome associated with colorectal adenocarcinoma in representatives of the Kazakhstan population. Study was performed with 282 colorectal cancer (CRC) patients and 159 controls. Genotyping of SNPs was performed by QuantStudio 12K Flex PCR.

Proinflammatory cytokines and colorectal cancer - the impact of the stage.

Colorectal cancer is one of the most often diagnosed malignant tumors. In Kazakhstan, high incidence of CC is registered along with other oncology diseases. Despite a significant progress in the disease treatment achieved lately, CC is still one of the major reasons of mortality due to oncologic pathologies.

Inflammatory Serum Biomarkers in Colorectal Cancer in Kazakhstan Population.

Colorectal cancer is a type of oncopathology widespread in Kazakhstan. The genetic component, as well as the possible etiopathogenetic mechanisms, is widely studied. One of the most promising areas is the study of diagnostic and prognostic possibilities of inflammatory biomarkers in patients with different degrees of tumor differentiation.

Stationary scaling in small-scale turbulent dynamo problem.

We consider forced small-scale magnetic field advected by an isotropic turbulent flow. The random driving force is assumed to be distributed in a finite region with a scale smaller than the viscous scale of the flow. The two-point correlator is shown to have a stationary limit for any reasonable velocity statistics.

Turbulent transport in reaction-diffusion systems.

The impact of turbulent advection in reaction-diffusion systems is investigated for the viscous range of scales. We show that the population size can increase exponentially even in systems with density saturation, at the expense of exponential propagation of the reaction front. Exact expressions for scaling exponents of the density and population size are calculated in different intermediate asymptotics of the process.

Influence of Combined Therapy on Generation of Neutrophil Extracellular Traps in Patients with Cervical Cancer.

Background: According to several authors, neutrophil extracellular traps (NETs) play an important role in the mechanisms of cancer development and metastatic processes, which allows them to be considered as a potential new target for the treatment of cancer.

Aim: To investigate the presence of extracellular neutrophil traps in the blood of patients with cervical cancer on the background of the combined treatment.

Materials And Methods: The study was conducted in 28 patients with cervical cancer.

LONG-TERM RESULTS OF COMBINATION THERAPY FOR LOCALLY ADVANCED BREAST CANCER.

Breast cancer ranks first among the malignant tumors in women. In locally advanced breast cancer (LABC) treatment starts with neoadjuvant chemotherapy (CTx) with the standard regimens CMF, FAC, АС. A cytostatic drug, Arglabin, isolated and produced from Artemisia glabella Kar.

ASSESSMENT OF DIRECT RESULTS OF CERVICAL CANCER COMBINED TREATMENT.

The aim of the study was to evaluate the immediate results of combined treatment of cervical cancer. This study included 177 patients with cervical cancer. The mean age of patients was 48.

Passive scalar transport by a non-Gaussian turbulent flow in the Batchelor regime.

We analyze passive scalar advection by a turbulent flow in the Batchelor regime. No restrictions on the velocity statistics of the flow are assumed. The properties of the scalar are derived from the statistical properties of velocity; analytic expressions for the moments of scalar density are obtained.

NEOADJUVANT СHEMOTHERAPY FOR LOCALLY ADVANCED BREAST CANCER.

93 patients with LABC (T2N1-2M0, T3N0-2M0) at the age from 35 to 75 years were included in the trial. With 2 stage - 60 patients, with the third stage - 33 patients. All patients were randomized into 3 groups: The I control group (n=36) received 4 courses of neoadjuvant chemotherapy according to AC-protocol (doxorubicin 50 mg/m2, cyclophosphan-500 mg/m2 on day 1, repeated every three weeks) followed by radical mastectomy, 4 courses of adjuvant chemotherapy (АС), radiotherapy and hormone therapy if indicated.

Microstructure of Spark Plasma-Sintered Silicon Nitride Ceramics.

The microstructure and phase composition of the high-content AlO-YO-doped spark plasma-sintered silicon nitride were investigated. Fully dense silicon nitride ceramics with a typical α-SiN equiaxed structure with average grain size from 200 to 530 nm, high elastic modulus of 288 GPa, and high hardness of 2038 HV were spark plasma sintered (SPSed) at 1550 °C. Silicon nitride with elongated β-SiN grains, higher hardness of 1800 HV, density of 3.

EPIDEMIOLOGY OF NEUROPATHIC CHRONIC PAIN IN ONCOLOGY PATIENTS.

The aim of the study was to analyze the primary prevalence of chronic neuropathic pain syndrome in oncology patients of Karaganda (Kazakhstan), to estimate the structure of pain syndrome in randomly chosen patients, to assess the effectiveness of analgesic therapy in oncology patients. All the patients with confirmed cancer admitted to hospital in Karaganda regional oncologic dispensary were studied. The study period was limited to 60 consecutive days.

Microstructure and Phase Composition of Cold Isostatically Pressed and Pressureless Sintered Silicon Nitride.

The microstructure and physical properties of new Y2O3 and Al2O3 oxide-doped silicon nitride ceramics fabricated by cold isostatic pressing and free sintering were investigated. The phase composition of produced material was also studied by X-ray diffraction at room and elevated temperature. The fabricated ceramics featured a microstructure of Si5AlON7 grains with a fine-grained α-Si3N4 with a small amount of Y2SiAlON5.

[ASSESSMENT OF ENERGY NEEDS AND THE ROLE OF NUTRITIONAL SUPPORT IN SENILE PATIENTS WITH INTESTINAL FAILURE IN ORTHOPEDIC SURGERY OF HIGH RISK].

The study of anamnestic, clinical, laboratory, endoscopic, morphological parallels of senile patients in knee and hip joints prosthesis shows the presence of intestinal failure while perioperative period. A direct connection between a natural intestinal and immune dysfunction and nutritional deficiency was diagnosed. The use of nutritional-metabolic correction of comorbid pathology and determination of basal metabolism in the perioperative period enabled to normalize indicators of homeostasis, microflora of the colon, indicators of immune status, and get a reduction in the number of early postoperative complications.

THE IMPORTANCE OF IMMUNOHISTOCHEMICAL STUDIES IN THE DIAGNOSIS OF CANCER OF UNKNOWN PRIMARY ORIGIN.

The purpose of the research is to give a comparative diagnostic characteristic to tumors of unknown primary origin by admission diagnosis and morphological diagnosis. 162 treated cases with tumors of unknown primary at Oncologic Dispensary for 5 years were analyzed in details. Besides clinical, instrumental, cytological, morphological methods, immunnohistochemical research of tumors was carried out by avidin-biotin-peroxydase tecnics.

Multifractal structure of fully developed turbulence.

The appearance of vortex filaments, the power-law dependence of velocity and vorticity correlations and their multiscaling behavior are derived from the Navier-Stokes equation. This is possible due to interpretation of the Navier-Stokes equation as an equation with multiplicative noise and remarkable properties of random matrix products.

Vortex filament model and multifractal conjecture.

We develop a theory of turbulence based on the inviscid Navier-Stokes equation. We get a simple but exact stochastic solution (vortex filament model) which allows us to obtain a power law for velocity structure functions in the inertial range. Combining the model with the multifractal conjecture, we calculate the scaling exponents without using the extended self-similarity approach.

Structure functions of fully developed hydrodynamic turbulence: an analytical approach.

We develop a theory of turbulence based on the inviscid Navier-Stokes equation, without using dimensional or phenomenological considerations. The theory allows us to obtain the scaling law and to calculate the scaling exponents of the Lagrangian and Eulerian velocity structure functions in the inertial range. The obtained results are shown to be in very good agreement with numerical simulations and experimental data.

Lagrangian and Eulerian velocity structure functions in hydrodynamic turbulence.

The Lagrangian and Eulerian transverse velocity structure functions of fully developed fluid turbulence are found based on the inviscid Navier-Stokes equation. The structure functions are shown to obey the scaling relations S(n)(L)(tau) proportional to tau(xi(n)) and S(n)(E)(l) proportional to l(zeta(n)) inside the inertial range. The scaling exponents zeta(n) and xi(n) are calculated analytically without using dimensional considerations.

Lagrangian statistical theory of fully developed hydrodynamical turbulence.

The Lagrangian velocity structure functions in the inertial range of fully developed fluid turbulence are for the first time derived based on the Navier-Stokes equation. For time tau much smaller than the correlation time, the structure functions are shown to obey the scaling relations K_{n}(tau) proportional, varianttau;{zeta_{n}}. The scaling exponents zeta_{n} are calculated analytically without any fitting parameters.

[Properties of blood serum from reindeer and results of using it in virology and biotechnology].

The blood serum of the reindeer does not virtually contain any antibodies to respiratory and intestinal viruses widely spread among the cattle. The reindeer blood serum is comparable with the bovine serum by the contents of chlorides, hemoglobin, total protein and protein fractions; however, it is different from the latter by a 2.5-fold higher content of glucose and by a higher osmotic pressure.