Attributes of FSW and UWFSW butt joints of armour grade AA5083 aluminium alloy: Impact of tool pin profile.

AA5083 is an alloy of military-grade aluminum used to make lightweight combat vehicles. Combining this material with traditional welding methods results in the formation of grain agglomerations, alloy separation, porosity, and pores. To overcome these shortcomings, Friction stir welding was utilized.

Discovery of reversible and covalent TEAD 1 selective inhibitors MSC-1254 and MSC-5046 based on one scaffold.

The Transcriptional Enhanced Associated Domain (TEAD) family of transcription factors are key components of the Hippo signalling family which play a crucial role in the regulation of cell proliferation, differentiation and apoptosis. The identification of inhibitors of the TEAD transcription factors are an attractive strategy for the development of novel anticancer therapies. A HTS campaign identified hit 1, which was optimised using structure-based drug design, to deliver potent TEAD1 selective inhibitors with both a reversible and covalent mode of inhibition.

A squalene oil emulsified MPL-A and anti-CD200/CD300a antibodies adjuvanted whole-killed Leishmania vaccine provides durable immunity against L. donovani parasites.

Antigenic inefficacy to induce robust immune responses and durable memory are major causes of constantly failing prophylactic approaches in leishmaniasis. Here, we determine the potential of a standardized whole-killed Leishmania vaccine (Leishvacc) adjuvanted with anti-CD200 and anti-CD300a antibodies, either alone or with monophosphoryl lipid A (MPL-SE) emulsified in squalene oil, in restoring the compromised antigen presenting abilities of dendritic cells (DCs), effector properties of CD4T cells and providing protection against Leishmania donovani parasites. In animals vaccinated with antibodies adjuvanted vaccines, either alone or with MPL-SE, the antigen presenting abilities of CD11c DCs against Leishmania antigens, measured in terms of CD80, CD86, MHC-I, and MHC-II surface receptors and intracellular IL-12 were found enhanced than non-adjuvanted vaccine.

A Complex Interplay between Nutrition and Alcohol use Disorder: Implications for Breaking the Vicious Cycle.

Approximately 16.5% of the United States population met the diagnostic criteria for substance use disorder (SUD) in 2021, including 29.5 million individuals with alcohol use disorder (AUD).

YouTube as a Patient Information Source for Gastrointestinal Reflux Disease.

Introduction Gastroesophageal reflux disease (GERD) affects a substantial portion of the global population, resulting in significant morbidity and impacting the quality of life. YouTube (YouTube, San Bruno, California) serves as a platform where medical professionals, individuals with personal experiences, and educational channels share their insights on GERD. However, with the vast amount of information available on YouTube, the question of credibility and reliability is a concern and, thus, is crucial to evaluate.

Dissimilar autogenous TIG joint of Alloy 617 and AISI 304H steel for AUSC application.

To reduce costs and improve high-temperature performance in Advanced Ultra Super Critical (AUSC) boilers, it is necessary to weld austenitic steel to Inconel alloy. In this study, the autogenous tungsten inert gas (TIG) welding process was used to join Alloy 617 and an austenitic AISI 304H steel plate of thickness 5 mm. Microstructural analysis showed that the microstructure formation was uneven along the weldments, with columnar and cellular dendrites near the interface while the central area of the weld exhibited a combination of columnar, cellular, and equiaxed dendrites.

High-Temperature Tensile Behaviour of GTAW Joints of P92 Steel and Alloy 617 for Two Different Fillers.

This study explores the high-temperature (HT) tensile rupture characteristics of a dissimilar gas-tungsten-arc-welded (GTAW) joint between P92 steel and Alloy 617, fabricated using ER62S-B9 and ERNiCrCoMo-1 fillers. The high-temperature tensile tests were performed at elevated temperatures of 550 °C and 650 °C. An optical microscope (OM) and a field emission scanning electron microscope (FESEM) were utilized to characterize the joint.

Assessment of carbon footprint of milk production and identification of its major determinants in smallholder dairy farms in Karnataka, India.

Indian dairy enterprise is dominated by smallholder dairy farms that contribute 72% of the country's total milk production. These smallholder dairy farms are often considered to emit substantial greenhouse gases (GHG) but are poor in productive performances. Therefore, it is crucial to estimate the carbon footprint (CF) of milk production of the smallholder Indian dairy farms.

P92 steel and inconel 617 alloy welds joint produced using ERNiCr-3 filler with GTAW process: Solidification mechanism, microstructure, mechanical properties and residual stresses.

The objective of the current study was to analyse the microstructure, mechanical characteristics, and residual stresses of a dissimilar welded joint (DWJ) made of P92 steel and the Inconel alloy 617 (IN617) using the gas tungsten arc welding (GTAW) method. The ERNiCr-3 filler was selected to produce the conventional V groove (VG) and narrow V groove (NVG) butt joint. The filler deficient zones in the weldments, such as the filler deficient beach, i.

Investigation of Severe Plastic Deformation Effects on Magnesium RZ5 Alloy Sheets Using a Modified Multi-Pass Equal Channel Angular Pressing (ECAP) Technique.

The present study investigates the effects of multiple passes of equal channel angular pressing (ECAP) on magnesium alloy sheets with the assistance of an Inconel plunger along with a die setup having a channel angle of 120° and corner angle of 10° operating at a temperature of 200 °C followed by the required heat treatment processes. The microstructural analysis of the sheet samples at various stages of the multi-pass hot ECAP has shown evidence of ultrafine grain refinement (UFG) due to the occurrence of severe plastic deformation. X-ray diffraction analysis has also exhibited the presence of phases like MgZn and CeZn which is supposedly responsible for the enhancement of the mechanical properties.

Swarna Bhasma Induces Antigen-Presenting Abilities of Macrophages and Helps Antigen Experienced CD4 T Cells to Acquire Th1 Phenotypes Against Leishmania donovani Antigens.

In leishmaniasis, the protective immunity is largely mediated by proinflammatory cytokine producing abilities of T cells and an efficient parasite killing by phagocytic cells. Notwithstanding a substantial progress that has been made during last decades, the mechanisms or factors involved in establishing protective immunity against Leishmania are not identified. In ancient Indian literature, metallic "bhasma," particularly that of "swarna" or gold (fine gold particles), is indicated as one of the most prominent metal-based therapeutic medicine, which is known to impart protective and curative properties in various health issues.

Recapitulating phenotypes of alcohol dependence via overexpression of Oprk1 in the ventral tegmental area of non-dependent TH::Cre rats.

The dynorphin (DYN)/kappa-opioid receptor (KOR) system is involved in dysphoria and negative emotional states. Dysregulation of KOR function promotes maladaptive behavioral regulation during withdrawal associated with alcohol dependence. Mesolimbic dopaminergic (DA) projections from the ventral tegmental area (VTA) innervate the extended amygdala circuitry and presynaptic KORs attenuate DA in these regions leading to an excessive alcohol consumption and negative affective-like behavior, whereas mesocortical KOR-regulated DA projections have been implicated in executive function and decision-making.

Ring shaped fs supercontinuum with a thermally induced self-diffraction effect.

A broadband femtosecond supercontinuum (SC) light with a dark core has been generated in a pump-probe type geometry. It has been achieved by introducing a small thermal perturbation in a highly absorbing medium with a continuous wave pump laser. The SC was generated with the help of a photonic crystal fiber and a nJ femtosecond oscillator.

Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead .

The dysregulated Hippo pathway and, consequently, hyperactivity of the transcriptional YAP/TAZ-TEAD complexes is associated with diseases such as cancer. Prevention of YAP/TAZ-TEAD triggered gene transcription is an attractive strategy for therapeutic intervention. The deeply buried and conserved lipidation pocket (P-site) of the TEAD transcription factors is druggable.

Influence of PWHT Parameters on the Mechanical Properties and Microstructural Behavior of Multi-Pass GTAW Joints of P92 Steel.

The 9% Cr steels were developed for ultra-supercritical (USC) power plants to meet the requirements of high operating temperature and pressure. These steels are produced to operate at high temperatures where impact toughness is not a concern; however, it becomes important for the welded joints to have good impact toughness at room temperature for manufacturing. The present work investigates the effect of the post-weld heat treatment (PWHT) parameters, i.

Economic losses in dairy farms due to heat stress in sub-tropics: evidence from North Indian Plains.

The present study assesses the sensitivity of dairy animals to thermal stress, and projects the economic losses due to heat stress in the Trans and Upper Gangetic plains region of India with Representative Concentration Pathway (RCP) 4.5 climate scenario for the time slice 2010-2039 and two subperiods, 2020-2029 and 2030-2039. The projections were carried out for two different scenarios of population and productivity growth of dairy animals, Business-as-Usual (BAU) and Alternate, whereby land, feed and fodder constraints were applied.

Dysregulated kappa-opioid receptors in the medial prefrontal cortex contribute to working memory deficits in alcohol dependence.

Impaired working memory is one symptom contributing to compromised executive function in alcohol use disorder (AUD). Dysregulation of cortical dynorphin (DYN) and κ-opioid receptors (KORs) has been implicated in alcohol dependence-induced impairment in executive function. The present experiments test the hypothesis that dysregulated medial prefrontal cortex (mPFC) KORs contribute to impaired working memory in alcohol dependence.

Understanding vulnerability of agricultural production system to climatic stressors in North Indian Plains: a meso-analysis.

Unlabelled: The present study has mapped the hot spots vulnerable to changing climate and identified the underlying driving indicators in subtropical Trans and Upper Gangetic plains (TUGP) of India. The long-term trends indicate that the area between latitude 25 and 28° N has been more exposed to adverse climatic changes especially rise in maximum summer/monsoon and minimum winter temperatures. The more predominant correlates of vulnerability in the region come not from the exposure to adverse meteorological conditions but from prevailing socio-economic conditions (adaptive capacity) and the increased environmental pressure (sensitivity).

Study on Microstructural Characterization, Mechanical Properties and Residual Stress of GTAW Dissimilar Joints of P91 and P22 Steels.

This article deals with the dissimilar joining of two different grade Cr-Mo steel (2.25Cr-1Mo: P22 and modified 9Cr-1Mo: P91) for power plant application. The dissimilar butt-welded joint was produced for conventional V groove design by using the gas tungsten arc welding (GTAW) process with the application of an ERNiCrMo-3 Ni-based super alloy filler.

Patterned Feeding of a Hyper-Palatable Food (Oreo Cookies) Reduces Alcohol Drinking in Rats.

While a bidirectional positive link between palatable food intake and alcohol drinking has been suggested, several rodents studies report reduced alcohol drinking following palatable diets exposure. These studies utilized purified rodents' diets high in sugar/fat; however, the effects of hyper-palatable food (HPF) rich in fat and sugar on alcohol drinking remain unclear. Furthermore, neural substrates involved in HPF-mediated changes in alcohol consumption are poorly understood.

Silver Nanoprism for Selective and Sensitive Detection of Hg Ions.

In this article, we propose high-performance colorimetric detection of Hg using silver nanoprisms. The spherical and triangular AgNPs were synthesized using varied concentration of NaBH4. Pristine AgNPs without any further modification were used for the detection of various metal ions including Hg, Pb, Cl, Cd, Co, Cu, Ba, Pb, Cr, Cr₂O , Fe, Fe etc.

Reduced alcohol drinking following patterned feeding: Role of palatability and acute contingent availability.

Recent studies from our lab have demonstrated that intermittent high-fat diet access reduces alcohol drinking in rats. However, it was unclear if caloric overload, palatability, or diet itself triggered reduced alcohol drinking. It is also unknown if a similar paradigm could reduce relapse-like alcohol drinking.

Behavioral and Neurobiological Consequences of Hedonic Feeding on Alcohol Drinking.

A complex interplay of peripheral and central signaling mechanisms within the body of an organism maintains energy homeostasis. In addition, energy/food intake is modified by various external factors (e.g.

Sensitivity of buffaloes () to heat stress.

Based on ten years of data (2001-10), consisting of 12 673 observations on fortnightly milk yield of buffaloes reared in a dairy farm located in the Northern sub-tropics (29°41'0″N, 76°59'0″E), the present study establishes the relationship between weather conditions and production performance of lactating buffaloes. The critical threshold level of maximum temperature-humidity index (THI) was estimated to be 74, which is higher than that of crossbred cows. The duration of discomfort period for buffaloes begins in mid-March and lasts up to early November.