Toward novel treatment against filariasis: Insight into genome-wide co-evolutionary analysis of filarial nematodes and .

Infectious diseases caused by filarial nematodes are major health problems for humans and animals globally. Current treatment using anti-helminthic drugs requires a long treatment period and is only effective against the microfilarial stage. Most species of filarial nematodes harbor a specific strain of bacteria, which are essential for the survival, development, and reproduction of the nematodes.