PD-L1 protein expression and copy number gains in HIV-positive locally advanced cervical cancer.

Background: The programmed death-1/programmed death-ligand-1 (PD-1/PD-L1) axis may represent a target for cervical cancer; however, it is poorly understood in human immunodeficiency virus (HIV)-infected patients.

Methods: We evaluated HIV-positive ( = 42) and HIV-negative ( = 110) women with locally advanced cervical cancer regarding their PD-L1 expression, determined by combined positive score (CPS) ⩾ 1 and tumor proportion score (TPS) ⩾ 25%, and PD-L1 copy number alterations, assessed by fluorescence hybridization.

Results: Regardless of HIV status, 84.