Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function.

Bacterial biofilms represent a challenge to the healthcare system because of their resilience against antimicrobials and immune attack. Biofilms consist of bacterial aggregates embedded in an extracellular polymeric substance (EPS) composed of polysaccharides, nucleic acids and proteins. We hypothesised that carbohydrates could contribute to immune recognition of Pseudomonas aeruginosa biofilms by engaging C-type lectins.

Corrigendum: Contribution of the Alkylquinolone Quorum-Sensing System to the Interaction of With Bronchial Epithelial Cells.

[This corrects the article DOI: 10.3389/fmicb.2018.

Contribution of the Alkylquinolone Quorum-Sensing System to the Interaction of With Bronchial Epithelial Cells.

causes infections in patients with compromised epithelial barrier function. Multiple virulence factors produced by are controlled by quorum sensing (QS) 2-alkyl-4(1)-quinolone (AQ) signal molecules. Here, we investigated the impact of AQs on PAO1 infection of differentiated human bronchial epithelial cells (HBECs).

Gamma Interferon and Interleukin-17A Differentially Influence the Response of Human Macrophages and Neutrophils to Pseudomonas aeruginosa Infection.

Macrophages are important orchestrators of inflammation during bacterial infection, acting as both effector cells and regulators of neutrophil recruitment and life span. Differently activated macrophage populations with distinct inflammatory and microbicidal potentials have been described. Our previous work unveiled a positive and a negative correlation between levels of gamma interferon (IFN-γ) and interleukin-17A (IL-17A), respectively, and lung function in cystic fibrosis, particularly in patients chronically infected with This study sought to define key parameters in human antibacterial immunity under Th1- and Th17-dominated inflammatory conditions; the final aim was to identify unique characteristics that could be fine-tuned therapeutically to minimize tissue damage while maximizing bacterial clearance.

A survey on depression among infertile women in Ghana.

Background: The desire of many young women to become parents may be influenced by the premium placed on children by society. In Africa, children are highly valued for social, cultural and economic reasons. Infertile and childless women in Africa are therefore confronted with a series of societal discrimination and stigmatization which may lead to psychological disorders such as anxiety and depression.