A meta-analysis of effects of and polymorphisms on phenytoin pharmacokinetic parameters.

Phenytoin is metabolized through CYP2C9 and CYP2C19 Polymorphisms of and may increase plasma concentration and side effects. Systematic review and meta-analysis were performed to evaluate the effects of and polymorphism on pharmacokinetic parameters. PubMed, Science Direct, Cochrane library, and Thai databases were systematically searched.