Synopsis of recent research by authors named "Sirika Pillay"
- Sirika Pillay's research primarily focuses on enhancing adeno-associated virus (AAV) technology for gene therapy applications, developing innovative models to improve tissue-specific gene expression and transduction efficiency in various organisms.
- Significant findings include the creation of the SELECTIV model which allows targeted expression of transgenes in specific cell types, and successful use of AAV-mediated gene regulation to address health issues, such as rescuing seizure phenotypes in a Dravet syndrome mouse model.
- Pillay's work has contributed to the understanding of AAV entry mechanisms, including the identification of key receptors and alternative entry pathways, which are vital for optimizing AAV as a therapeutic vector in gene delivery.
