Publications by authors named "Sirayut Phatthanasobhon"

Background: Evidence on antidementia drugs (ADD) use in developing countries, where accessibility to ADD is challenging, is limited. Our aim was to examine prescribing patterns, factors, and outcomes associated with the early-ADD use (within 3 months from diagnosis) in people with dementia.

Methods: A retrospective cohort study included individuals aged ≥ 60 years with dementia from three hospitals in Thailand between 2015 and 2020.

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Article Synopsis
  • - The study examines how common potentially inappropriate medications (PIMs) are among older hospital patients and what factors influence their use, using data from 20,629 patients between 2021 and 2023.
  • - Findings reveal that 91.32% of the patients were prescribed PIMs, with higher risks of PIM use linked to being female, longer hospital stays, more medications, and multiple chronic conditions.
  • - Despite the high prevalence of PIMs, the study concluded that their use did not significantly affect rehospitalisation rates, length of hospital stays, or overall medical costs within one year after discharge.
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We performed a network meta-analysis of randomised controlled trials (RCTs) and non-randomised studies in adult peritoneal dialysis patients to evaluate the effects of specific renin-angiotensin aldosterone systems (RAAS) blockade classes on residual kidney function and peritoneal membrane function. Key outcome parameters included the following: residual glomerular filtration rate (rGFR), urine volume, anuria, dialysate-to-plasma creatinine ratio (D/P Cr), and acceptability of treatment. Indirect treatment effects were compared using random-effects model.

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A tool to predict peritonitis-associated treatment failure among peritoneal dialysis (PD) patients has not yet been established. We conducted a multicentre, retrospective cohort study among 1,025 PD patients between 2006 and 2016 in Thailand to develop and internally validate such a tool. Treatment failure was defined as either a requirement for catheter removal, a switch to haemodialysis, or peritonitis-associated mortality.

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