Publications by authors named "Siqing Zheng"

Background: A pathophysiological feature of septic organ failure is endothelial dysfunction in sepsis (EDS). The physiological and pathological mechanism of sepsis is considered to be vascular leakage caused by endothelial dysfunction. These pathological changes lead to systemic organ injury.

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  • Cellular metabolism is essential for energy and building blocks in cells, and ongoing studies are enhancing our understanding of diseases and leading to new treatments.
  • RNA modifications play a significant role in epigenetics and affect various biological functions, including influencing immune cell metabolism and responses.
  • The review discusses various RNA modifications, their roles in metabolism related to health and disease, and the potential for RNA modification-targeted therapies in clinical settings.
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N6-methyladenosine (m6A) is the most prevalent internal modification in mammalian messenger RNAs and is associated with numerous biological processes. However, its role in chromosomal instability remains to be established. Here, we report that an RNA m6A methyltransferase, METTL16, plays an indispensable role in the progression of chromosome segregation and is required to preserve chromosome stability in colorectal cancer (CRC) cells.

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  • Reactive sulfur species (RSS), including hydrogen sulfide (HS) and sulfur monoxide (SO), play crucial roles in various physiological processes, but their functions are not well understood due to difficulties in accurate detection.
  • A new nanosensor, combining silver nanoparticles with a MIL-101 (Fe) hybrid, allows for the simultaneous detection of HS and SO in living cells by utilizing surface enhanced Raman spectroscopy (SERS) and fluorescent signals.
  • This dual-modal sensing platform can detect very low concentrations of HS (2.8 × 10 μM) and SO (0.003 μM) while successfully targeting mitochondria and minimizing interference between the signals, aiding in the study of physiological issues linked to RSS.
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Accurate and selective in-field detection of metal ions in complex media has gained wide interests due to the complexed matrices and weak affinity towards sensing surface. Herein, we develop a first trimodal method for sensing of Zn in complex matrices by stimuli-responsive N-[6-piperazinyl-2-pyridinyl]-N-(2-pyridinylmethyl)-2-Pyridinemethanamine dithiocarbamates (DPY) modified gold nanorods (GNRs-DPY). The presence of Zn triggers the aggregation of GNRs-DPY, leading to increment of color and fluorescence intensity of the sensing system, which could be visually discerned with bare eye.

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This study develops a dual-channel colorimetric and surface-enhanced Raman scattering (SERS) strategy for detection of Cu utilizing Ag-Au core-satellite nanostructures. 4-mercaptobenzoic acid (MBA) modified Ag nanoparticles (AgNPs@MBA) and 4-mercaptopyridine (Mpy) capped AuNPs (GNPs@Mpy) are first designed via metal-sulfur bonds, respectively. Benefiting from the Cu-triggered NPs self-aggregation, the dispersion of AgNPs-GNPs (AgNPs@MBA + GNPs@Mpy) is turned into AgNPs-Cu-GNPs core-satellite structures.

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Accurately measuring tree diameter at breast height (DBH) and estimating tree positions in a sample plot are important in tree mensuration. The main aims of this paper include (1) developing a new, integrated device that can identify trees using the quick response (QR) code technique to record tree identifications, measure DBH, and estimate tree positions concurrently; (2) designing an innovative algorithm to measure DBH using only two angle sensors, which is simple and can reduce the impact of eccentric stems on DBH measures; and (3) designing an algorithm to estimate the position of the tree by combining ultra-wide band (UWB) technology and altitude sensors, which is based on the received signal strength indication (RSSI) algorithm and quadrilateral localization algorithm. This novel device was applied to measure ten 10 × 10 m square plots of diversified environments and various tree species to test its accuracy.

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