Publications by authors named "Siqing Yi"
Objective: To explore the value of dual-accelerated simultaneous multi-slice (SMS) imaging in diffusion tensor imaging (DTI) of glioma.
Methods: Thirty-four patients with glioma who underwent magnetic resonance imaging (MRI) in our hospital from January 2022 to March 2023 were randomly selected. The results of dual-accelerated SMS-DTI and conventional DTI were retrospectively analyzed.
Establishment of Prognosis Nomogram for Primary Splenic Diffuse Large B Cell Lymphoma: A Study Based on SEER Database.
Indian J Hematol Blood Transfus
April 2024
Despite being the most common primary tumor of the spleen, in the past, few studies have predicted the prognosis of primary spleen diffuse large B cell lymphoma. This study aimed to establish a nomogram prediction model of overall survival in primary DLBCL of the spleen. We screened out 347 patients with primary splenic DLBCL from surveillance, epidemiology, and end results database.
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- Long noncoding RNAs (lncRNAs) like LINC02086 play significant roles in the development of malignant tumors, particularly pancreatic cancer (PC), where their function had not been fully studied before.
- The research found that LINC02086 is highly expressed in PC tissues and is linked to poor patient outcomes; its knockdown led to an increase in ferroptosis (a form of cell death) in PC cells, suggesting it supports cancer growth.
- LINC02086 acts as a competitive endogenous RNA that sequesters miR-342-3p, which usually helps suppress cancer progression, and this interaction increases the expression of CA9, ultimately promoting the aggressive behavior of pancreatic cancer cells.
Background: Circulating tumor DNA (ctDNA) has emerged as a potential diagnostic and prognostic biomarker in various tumors. However, the role of tumor suppressor genes (TSGs) methylation in ctDNA of patients with pancreatic cancer (PC) remains largely unclear.
Methods: Patients with PC (n = 43), pancreatic benign diseases (n = 39), and healthy controls (n = 20) were enrolled in the study.
Background: Extensive studies on the link between single nucleotide polymorphisms (SNPs) in vascular endothelial growth factor (VEGF) and various malignancy risks produced conflicting results, notably for VEGF-460(T/C). To evaluate this correlation more comprehensively and accurately, we perform a meta-analysis.
Methods: Through retrieving 5 databases (Web of Science (WoS), Embase, Pubmed, Wanfang database (Wangfang), and China National Knowledge Infrastructure (CNKI)) and applying hand search, citation search, and gray literature search, 44 papers included 46 reports were enrolled.
Article Synopsis
- - Tumor-infiltrating lymphocytes (TILs) play a key role in pancreatic cancer's tumor microenvironment, with changes in their levels linked to various clinical characteristics and prognosis.
- - Research found that pancreatic cancer tissues show a decrease in total T cells, CD4 T cells, and CD8 cytotoxic T lymphocytes, while regulatory T cells (Tregs) and PD-L1 T cells are increased compared to surrounding healthy tissues.
- - The presence of specific TILs, including total T cells, CD4 T cells, Tregs, and PD-L1 T cells, serves as potential independent risk factors for predicting the prognosis of pancreatic cancer.
Article Synopsis
- Primary splenic diffuse large B cell lymphoma (DLBCL) is a rare but increasing tumor type in the spleen, and its treatment effectiveness has not been well-studied.
- This study examined 347 patients with primary splenic DLBCL, classifying them into four treatment groups: non-treatment, splenectomy only, chemotherapy only, and splenectomy combined with chemotherapy.
- Results indicated that the splenectomy combined with chemotherapy group had significantly better overall survival and cancer-specific survival compared to the non-treatment and splenectomy groups, while the chemotherapy-only group showed no significant difference in survival compared to the combination group.
BACKGROUND Pancreaticoduodenectomy (PD) and distal pancreatectomy with splenectomy (DPS) are considered the standard procedures for pancreatic lesions. However, long-term metabolic consequences of PD and DPS applied for benign or low-grade malignant tumors need to be addressed. This study aimed to investigate the short- and long-term outcomes of organ-sparing pancreatectomy for benign or low-grade malignant pancreatic tumors in our institution.
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