Publications by authors named "Siqin Liao"

Article Synopsis
  • About 10%-30% of Hodgkin's lymphoma patients experience relapse or treatment resistance after first-line therapy, making subsequent treatment difficult, particularly after failure of Brentuximab vedotin (BV) and immune checkpoint inhibitors (ICIs).
  • A study analyzed 19 patients with relapsed/refractory Hodgkin's lymphoma who underwent radiotherapy after BV or ICI failure, finding a 100% overall response rate and a median duration of response of 17.2 months.
  • The 1-year progression-free survival and overall survival rates were 84.4% and 100%, respectively, with no serious adverse events reported, demonstrating that radiotherapy is both effective and safe for this patient group.
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Article Synopsis
  • Radiotherapy (RT) is a local treatment option for patients with refractory or relapsed aggressive B-cell lymphomas, but the effectiveness of hypofractionated RT had not been previously confirmed.
  • A study analyzed 30 patients who received hypofractionated RT, showing a high objective response rate (90%) and complete response rate (80%), with promising one-year overall survival (81.8%) and progression-free survival (66.3%).
  • The findings indicate that hypofractionated RT is both effective and tolerable, particularly for patients with localized residual disease, as no serious side effects were reported.
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In this article, a synchronization control method is studied for coupled neural networks (CNNs) with constant time delay using sampled-data information. A distributed control protocol relying on the sampled-data information of neighboring nodes is proposed. Lyapunov functional is constructed to analyze the synchronization of CNNs with constant time delay.

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Introduction: Radiation-induced lung injury (RILI) is one of the most clinically-challenging toxicities and dose-limiting factors during and/or after thoracic radiation therapy for oesophageal squamous cell carcinoma (ESCC). With limited effective protective drugs against RILI, the main strategy to reduce the injury is strict adherence to dose-volume restrictions of normal lungs. RILI can manifest as acute radiation pneumonitis with cellular injury, cytokine release and cytokine recruitment to inflammatory infiltrate, and subsequent chronic radiation pulmonary fibrosis.

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Background: Limited evidence supports the omission of routine bone marrow (BM) examination (biopsy and aspiration) in patients with nasal-type extranodal NK/T-cell lymphoma (ENKTCL). This study was aimed at assessing whether BM examination provides valuable information for positron emission tomography/computed tomography (PET/CT)-based staging in this patient population.

Patients And Methods: Patients newly diagnosed with ENKTCL who underwent initial staging with both PET/CT and BM examination between 2013 and 2020 were retrospectively identified in two Chinese institutions.

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Background: Regional lymph node (LN) metastasis is a significant factor influencing the treatment choice of esophageal squamous cell carcinoma (ESCC). The performance PET/CT as an imaging evaluation method for regional LNs in ESCC, is unsatisfactory due to the lack of logical criterion. We explored how a modified criterion improved the diagnostic value of F-FDG PET/CT in regional LN metastasis.

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Deep reinforcement learning (DRL) is a machine learning method based on rewards, which can be extended to solve some complex and realistic decision-making problems. Autonomous driving needs to deal with a variety of complex and changeable traffic scenarios, so the application of DRL in autonomous driving presents a broad application prospect. In this article, an end-to-end autonomous driving policy learning method based on DRL is proposed.

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Central nervous system (CNS) involvement is a rare manifestation of multiple myeloma (MM) and the optimal management strategies have yet to be determined. The aim of the present study was to describe the case of a 47-year-old male patient with immunoglobulin D-λ MM who presented with multiple extramedullary infiltrations at diagnosis. This patient achieved stringent complete response after 9 cycles of treatment with bortezomib, lenalidomide and dexamethasone, and then received lenalidomide as maintenance therapy.

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Objective: To explore the preoperative diagnostic value of ¹⁸F-fluorodexyglucose positron emission tomography combined with contrast enhanced computed tomography (¹⁸F-FDG PET-ceCT) in patients with colorectal cancer liver metastasis.

Methods: Clinical and imaging data of 58 patients with suspicious colorectal cancer liver metastasis between April 2010 and March 2013 were retrospectively evaluated. All the patients underwent ¹⁸F-FDG PET-ceCT.

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