Publications by authors named "Siqin Jiang"
Heart regeneration was mainly achieved by intrinsic capacity. Exosomes are crucial in cardiovascular disease, yet their involvement in myocardial regeneration remains underexplored. To understand the role of cardiomyocyte-derived exosomes (CM-Exos) in heart regeneration.
View Article and Find Full Text PDFTargeting Skp2 degradation with troxerutin decreases neointima formation.
Eur J Pharmacol
November 2024
Article Synopsis
- Vascular smooth muscle cells (VSMCs) contribute to the formation of neointima after vascular injury, which is a key aspect of diseases like atherosclerosis and pulmonary hypertension.
- The protein Skp2 promotes VSMC proliferation and migration, making it a potential target for treatment.
- The study found that troxerutin, a natural flavonoid, effectively reduced VSMC viability and Skp2 levels, leading to decreased neointima formation and suggesting its role as a therapeutic agent.
Ubiquitin-proteasome system (UPS) is involved in vascular smooth muscle cell (VSMC) proliferation. Deubiquitinating enzymes (DUBs) have an essential role in the UPS-regulated stability of the substrate; however, the function of DUBs in intimal hyperplasia remains unclear. We screened DUBs to identify a protein responsible for regulating VSMC proliferation and identified USP14 protein that mediates cancer development, inflammation, and foam cell formation.
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