Publications by authors named "Siqi Zang"
Article Synopsis
- The study investigates the edible fern's different parts for their volatile components, flavonoid contents, antioxidant activities, and potential medicinal benefits, as previous research mainly focused on young fronds and rhizomes.
- Results indicated significant variations in antioxidant activities and flavonoid contents among the fern's parts, with crozier showing the highest antioxidant effects and underground parts having notable acetylcholinesterase (AChE) inhibition.
- Common volatile compounds identified include furfural and 5-methyl-2-furancarboxaldehyde, with additional volatile components from roots and leaves being valuable for food, cosmetics, and pharmaceutical uses.
Sulfobutyl ether-beta-cyclodextrin sodium salt contained in the marketed intravenous voriconazole injection as a solubilizer may cause harmful accumulations. This study aimed to evaluate the safety, tolerability, and pharmacokinetics (PKs) of two intravenous voriconazole formulations containing excipients from different manufacturers using increasing dose administrations in healthy Chinese volunteers. A randomized, double-blind, placebo-controlled trial was conducted in three cohorts with 42 healthy Chinese volunteers.
View Article and Find Full Text PDFOur objective is to explore the effect of applying cloud video conferencing methods to the informed consent process in an early-phase clinical trial during the COVID-19 pandemic. All participants who intended to participate in the trial were informed via a cloud video conference before signing the informed consent forms (ICF). Then, the attitudes of the participants with the cloud video conference and their understanding of the trial were evaluated using a questionnaire when they visited to sign the ICF onsite.
View Article and Find Full Text PDFObjectives: To evaluate the pharmacokinetic properties and safety of empagliflozin, and the bioequivalence of test formulation empagliflozin tablet compared with the brand-name drug Jardiance (reference formulation) after single oral administration under fasting and fed conditions in healthy Chinese subjects.
Methods: An open-label randomized single-dose two-sequence, two-treatment, two-period crossover study was conducted in healthy Chinese subjects, with 30 subjects under fasting condition and another 30 subjects under fed condition. Under each condition, subjects received a single oral administration of either the test or reference empagliflozin formulation, and then they received a single oral dose of the other formulation after a 7-day washout period.