Publications by authors named "Siqi Qiu"

Hepatic angiosarcoma is a rare yet aggressive malignancy, which is prone to misdiagnosis due to the lack of specific molecular and radiological characteristics. The treatment regimens remain controversial and disappointing. Randomized clinical trials are limited due to the rarity of this specific aggressive malignancy.

View Article and Find Full Text PDF

phase II, randomized, double blinded, multi-center study aims to explore whether intravenous edaravone dexborneol (ED) could improve clinical outcomes in patients with anterior circulation stroke with successful endovascular reperfusion (ClinicalTrials.gov: NCT04667637 Eligible patients were randomly (1:1) assigned into ED, which received intravenous ED (37.5 mg, 2/day, for 12 days) or control group, which received placebo.

View Article and Find Full Text PDF

Purpose: Precise tumor excision is important but challenging in breast-conserving surgery (BCS). Tumor-specific fluorescence imaging may be used for intraoperative tumor detection and, therefore, to guide precise tumor excision. The aims of this study are to develop a glucose transporter 1 (GLUT1)-targeted near-infrared fluorescence tracer and evaluate its accuracy for breast cancer detection using fresh surgical breast specimens.

View Article and Find Full Text PDF

Purpose: Precise tumor excision is important in breast-conserving surgery (BCS). This study explores the safety and accuracy of fluorescence image-guided BCS (FIGS) using a lidocaine mucilage-ICG compound (L-ICG).

Methods: 54 patients who underwent BCS from August 2020 to September 2023 were enrolled.

View Article and Find Full Text PDF

CD8 T cell spatial distribution in the context of tumor microenvironment (TME) dictates the immunophenotypes of tumors, comprised of immune-infiltrated, immune-excluded and immune-desert, discriminating "hot" from "cold" tumors. The infiltration of cytotoxic CD8 T cells is associated with favorable therapeutic response. Hitherto, the immunophenotypes of esophageal squamous cell carcinoma (ESCC) have not yet been comprehensively delineated.

View Article and Find Full Text PDF

Optical logic operation is promising for ultrafast information processing and optical computing due to the high computation speed and low power consumption. However, conventional optical logic devices require either a complex structure and circuit design or a constant voltage supply, which impedes the development of high-density integrated circuits. Here, all-optical logic devices are designed using a self-powered polarization-sensitive photodiode of the GeSe homojunction, which is attributed to an anisotropic band structure and built-in electric field.

View Article and Find Full Text PDF

Background: Immune checkpoint blockade (ICB) has been improving the patient outcome in multiple cancer types. However, not all patients respond to ICB. Biomarkers are needed for selecting appropriate patients to receive ICB.

View Article and Find Full Text PDF

Oral cancer represents a serious public health problem affecting oral and system health with a high global incidence. Treatment strategies for oral cancer vary in different disciplines and are likely to be limited to certain doctor's personal experience. While clinical practice guidelines are considered to enable doctors to determine the most appropriate and consistent treatment strategy according to the patient's situation.

View Article and Find Full Text PDF

Background: Currently, there are no optimal biomarkers available for distinguishing patients who will respond to immune checkpoint inhibitors (ICIs) therapies. Consequently, the exploration of novel biomarkers that can predict responsiveness to ICIs is crucial in the field of immunotherapy.

Methods: We estimated the proportions of 22 immune cell components in 10 cancer types (6,128 tumors) using the CIBERSORT algorithm, and further classified patients based on their tumor immune cell proportions in a pan-cancer setting using k-means clustering.

View Article and Find Full Text PDF
Article Synopsis
  • Systolic blood pressure (SBP) was examined as a factor in the effectiveness of dual antiplatelet versus intravenous alteplase in reducing early neurological deterioration (END) in stroke patients based on data from the ARAMIS trial.
  • The analysis categorized patients into two SBP groups (≥140 mmHg and <140 mmHg) and compared outcomes of those receiving each treatment within these subgroups.
  • Results indicated that dual antiplatelet treatment significantly reduced END in patients with SBP ≥140 mmHg, while it had little effect for those with SBP <140 mmHg, suggesting that higher SBP may influence treatment effectiveness.
View Article and Find Full Text PDF

Third harmonic generation (THG) microscopy shows great potential for instant pathology of brain tumor tissue during surgery. However, due to the maximal permitted exposure of laser intensity and inherent noise of the imaging system, the noise level of THG images is relatively high, which affects subsequent feature extraction analysis. Denoising THG images is challenging for modern deep-learning based methods because of the rich morphologies contained and the difficulty in obtaining the noise-free counterparts.

View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on improving predictions of pathological complete response (pCR) for breast cancer patients undergoing neoadjuvant chemotherapy (NAC) by combining insights from biopsy tissue images with clinical data.* -
  • Researchers analyzed 440 breast cancer patients' biopsy samples, using deep learning models to extract features from pathological images and develop a multimodal prediction model based on a support vector machine (SVM) classifier.* -
  • The results showed that the best-performing model had area under the curve (AUC) values that exceeded 0.70, with notable improvements in prediction accuracy when integrating pathological images and clinical features.*
View Article and Find Full Text PDF

Near-infrared II fluorescent probes targeting tumors for diagnostic purposes have received much attention in recent years. In this study, a fluorescent probe for the NIR-II was constructed by using IRDye800CW-NHS fluorescent dye with Trastuzumab, which was investigated for its ability to target HER-2-positive breast cancer in xenograft mice models. This probe was compared with Trastuzumab-ICG which was synthesized using a similar structure, ICG-NHS.

View Article and Find Full Text PDF

1,1'-Dihydroxy-5,5'-bi-tetrazolium dihydroxylamine salt (TKX-50) is a new type of high-energy low-sense explosive with great application value, but TKX-50 made directly from the reaction has problems such as irregular crystal morphology and relatively large length-diameter, and these factors seriously affect the sensitivity of TKX-50 and limit its large-scale application. The internal defects of TKX-50 crystals have a great influence on their weakness, and studying its related properties is of great theoretical significance and application value. To further investigate the microscopic properties of TKX-50 crystals and to explore the connection between microscopic parameters and macroscopic susceptibility, this paper reports the use of molecular dynamics simulations to construct TKX-50 crystal scaling models with three types of defects-vacancy, dislocation and doping-and conducts molecular dynamics simulations.

View Article and Find Full Text PDF

Targeted anticancer drugs block cancer cell growth by interfering with specific signaling pathways vital to carcinogenesis and tumor growth rather than harming all rapidly dividing cells as in cytotoxic chemotherapy. The Response Evaluation Criteria in Solid Tumor (RECIST) system has been used to assess tumor response to therapy via changes in the size of target lesions as measured by calipers, conventional anatomically based imaging modalities such as computed tomography (CT), and magnetic resonance imaging (MRI), and other imaging methods. However, RECIST is sometimes inaccurate in assessing the efficacy of targeted therapy drugs because of the poor correlation between tumor size and treatment-induced tumor necrosis or shrinkage.

View Article and Find Full Text PDF

Purpose: The number of M1-like and M2-like tumour-associated macrophages (TAMs) and their ratio can play a role in breast cancer development and progression. Early clinical trials using macrophage targeting compounds are currently ongoing. However, the most optimal detection method of M1-like and M2-like macrophage subsets and their clinical relevance in breast cancer is still unclear.

View Article and Find Full Text PDF

Liupao tea is an important dark tea, but few studies on purified Liupao tea polysaccharide (TPS) are reported in the literature. In this study, two TPSs, named TPS2 and TPS5, with molecular weights of 70.5 and 133.

View Article and Find Full Text PDF

Background: Patients who achieve a tumor pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) have better outcomes than patients with residual tumor. However, tumors still recur in the pCR patients. Therefore, we aim to explore factors associated with tumor recurrence in this patient population.

View Article and Find Full Text PDF

In order to analyze the influence of nitroguanidine (NQ) spheroidization on the corresponding characteristics of slow cook-off molten cast explosives, experiments and simulation calculations were carried out. A calculation method was established, based on a multiphase flow model to simulate the response process of spherical NQ-based molten cast explosives under slow cook-off conditions, to analyze the temperature distribution and liquid phase distribution during the reaction process, and to discuss the reaction temperature, reaction time and reaction location with the change of solid content. The study found that the slow cook-off response level of spherical NQ-based molten cast explosives is deflagration; the phase change cloud diagram can be used to determine the ignition time to obtain more accurate slow cook-off response data; when the solid content is 50%, the ignition temperature of ordinary NQ-based molten cast explosives is 454.

View Article and Find Full Text PDF

The chemokine CXCL9 (C-X-C motif chemokine ligand 9) has been reported to be required for antitumour immune responses following immune checkpoint blockade. In this study, we sought to investigate the potential value of CXCL9 according to immune responses in patients with breast cancer (BC). A variety of open-source databases and online tools were used to explore the expression features and prognostic significance of CXCL9 in BC and its correlation with immune-related biomarkers followed by subsequent verification with immunohistochemistry experiments.

View Article and Find Full Text PDF

Purpose: The reoperation rate for breast-conserving surgery is as high as 15-30% due to residual tumor in the surgical cavity after surgery. In vivo tumor-targeted optical molecular imaging may serve as a red-flag technique to improve intraoperative surgical margin assessment and to reduce reoperation rates. Cysteine cathepsins are overexpressed in most solid tumor types, including breast cancer.

View Article and Find Full Text PDF

Background: Breast cancer is rare in men, but management is focused on tumor characteristics commonly found in female breast cancer. The tumor microenvironment of male breast cancer is less well understood, and insight may improve male breast cancer management. The hepatocyte growth factor (HGF)/c-MET axis and the stromal cell-derived factor-1 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) axis are prognostic in women with breast cancer.

View Article and Find Full Text PDF

With the development of the internet of things (IoTs), big data, smart sensing technology, and cloud technology, the industry has entered a new stage of revolution. Traditional manufacturing enterprises are transforming into service-oriented manufacturing based on prognostic and health management (PHM). However, there is a lack of a systematic and comprehensive framework of PHM to create more added value.

View Article and Find Full Text PDF

The androgen receptor (AR) is a drug target in breast cancer, and AR-targeted therapies have induced tumor responses in breast cancer patients. In this review, we summarized the role of AR in breast cancer based on preclinical and clinical data. Response to AR-targeted therapies in unselected breast cancer populations is relatively low.

View Article and Find Full Text PDF