Unravelling the complex interplay of cuproptosis, lncRNAs, and immune infiltration in Alzheimer's disease: a step towards novel therapeutic targets.

Background: Cuproptosis, a type of cell death involving copper ion accumulation and oxidative stress, has been implicated in the development of Alzheimer's disease (AD).

Aim: This study aimed to explore the potential mechanisms and roles of cuproptosis-related genes (CRGs), long non-coding RNAs (lncRNAs), and immune cells in the development of cuproptosis in AD.

Subjects And Methods: Gene expression profiles of AD were acquired from the Gene Expression Omnibus (GEO) database, and differential analysis was conducted to identify CRGs.

Impact of oil price volatility and economic policy uncertainty on business investment - Insights from the energy sector.

This research employs a worldwide sample of 4017 energy sector companies from 1996 to 2022 to examine the effects of economic policy uncertainty (EPU) and oil price uncertainty (OPU) on corporate investment in oil/energy sector and this study analyze how market instability and international economic disasters shape the connection between OPU and business assets. GLM regression with firms-years fixed effects and firm-based clustering indicate that both OPU and EPU had a detrimental influence on corporate investment in energy sector. Generalized linear models provide a universal method for addressing various response modeling issues.

Free-Standing Single Ag Nanowires for Multifunctional Optical Probes.

Miniaturized and manipulable optical probes are the foundation for developing in situ characterization devices in confined space. We developed two methods for fabricating free-standing single Ag nanowires (AgNWs) directly at the tip of a glass capillary either by chemical or electrochemical reduction. The electrochemical nature of both methods resulted in a rapid growth rate of AgNWs up to 1.