A bifunctional amylopullulanase of Streptococcus suis ApuA contributes to immune evasion by interaction with host complement C3b.

The complement system is the first defense line of the immune system. However, pathogens have evolved numerous strategies to evade complement attacks. Streptococcus suis is an important zoonotic bacterium, harmful to both the pig industry and human health.

HylS', a fragment of truncated hyaluronidase of , contributes to immune evasion by interaction with host complement factor C3b.

Pathogenic bacteria have evolved many strategies to evade surveillance and attack by complements. is an important zoonotic pathogen that infects humans and pigs. Hyaluronidase (HylA) has been reported to be a potential virulence factor of .

NQO1 Mediates Lenvatinib Resistance by Regulating ROS-induced Apoptosis in Hepatocellular Carcinoma.

Objective: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death worldwide. As a first-line drug for advanced HCC treatment, lenvatinib faces a significant hurdle due to the development of both intrinsic and acquired resistance among patients, and the underlying mechanism remains largely unknown. The present study aims to identify the pivotal gene responsible for lenvatinib resistance in HCC, explore the potential molecular mechanism, and propose combinatorial therapeutic targets for HCC management.

Native ApxIIA secreted by Actinobacillus pleuropneumoniae induces apoptosis in porcine alveolar macrophages dependent on concentration and acylation.

Actinobacillus pleuropneumoniae is an important swine respiratory pathogen causing substantial economic losses to the global pig industry. The Apx toxins of A. pleuropneumoniae belong to the RTX toxin family and are major virulence factors.

Non-human primate models and systems for gait and neurophysiological analysis.

Brain-computer interfaces (BCIs) have garnered extensive interest and become a groundbreaking technology to restore movement, tactile sense, and communication in patients. Prior to their use in human subjects, clinical BCIs require rigorous validation and verification (V&V). Non-human primates (NHPs) are often considered the ultimate and widely used animal model for neuroscience studies, including BCIs V&V, due to their proximity to humans.

v-NiS/NiS Heterostructures Achieving Ultralow Overpotential in Alkaline Hydrogen Evolution.

The hydrogen evolution reaction (HER) usually has slow kinetics in an alkaline environment because of the lack of binding protons. Herein, we use a simple strategy to prepare NiS/NiS heterostructure (HS) electrocatalysts rich in sulfur vacancies (v). The v-NiS/NiS HSs demonstrate an ultralow overpotential of 44 mV at the current density of 10 mA cm and corresponding Tafel slope of 42 mV dec.

The Intracellular Interaction of Porcine β-Defensin 2 with VASH1 Alleviates Inflammation via Akt Signaling Pathway.

Defensins are a major class of antimicrobial peptides that facilitate the immune system to resist pathogen infection. To date, only β-defensins have been identified in pigs. In our previous studies, porcine β-defensin 2 (PBD-2) was shown to have both bactericidal activity and modulatory roles on inflammation.

Reduced overpotential of methane-producing biocathodes: Effect of current and electrode storage capacity.

Cathode overpotential is a key factor in the energy efficiency of bioelectrochemical systems. In this study the aim is to demonstrate the role of applied current density and electrode storage capacity on cathode overpotential. To do so, eight reactors using capacitive granular activated carbon as cathode material were operated.

Identification of FtpA, a Dps-Like Protein Involved in Anti-Oxidative Stress and Virulence in Actinobacillus pleuropneumoniae.

Bacteria have evolved a variety of enzymes to eliminate endogenous or host-derived oxidative stress factors. The Dps protein, first identified in Escherichia coli, contains a ferroxidase center, and protects bacteria from reactive oxygen species damage. Little is known of the role of Dps-like proteins in bacterial pathogenesis.