Publications by authors named "Siqi Linsey Zhang"
Sepsis is the leading postnatal cause of neonatal mortality worldwide. Globally Klebsiella pneumoniae is the leading cause of sepsis in hospitalized neonates. This study reports the development and evaluation of an ELISA for anti-Klebsiella IgG using dried blood spot (DBS) samples and evaluates the association of anti-Klebsiella IgG (anti-Kleb IgG) antibodies in maternal and neonatal samples with the risk of neonatal sepsis.
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- Sepsis is the top cause of death in newborns worldwide, with global hospitalizations primarily due to this condition.
- This study developed an ELISA test for measuring anti-IgG antibodies using dried blood spots and analyzed their levels in both mothers and neonates to assess their link to neonatal sepsis risk.
- Results showed that both affected neonates and their mothers had lower levels of anti-IgG antibodies, indicating a potential protective role of maternal antibodies against neonatal sepsis, highlighting the importance of further research in creating vaccines for mothers to protect their newborns.