DGPDR: discriminative geometric perception dimensionality reduction of SPD matrices on Riemannian manifold for EEG classification.

Manifold learning with Symmetric Positive Definite (SPD) matrices has demonstrated potential for classifying Electroencephalography (EEG) in Brain-Computer Interface (BCI) applications. However, SPD matrices may lead to crucial information loss of EEG signals. This paper proposes a dimensionality reduction method based on discriminative geometric perception on the Riemannian manifold to enhance SPD matrix discriminability.

Inoculation of Lactobacillus parafarraginis enhances silage quality, microbial community structure, and metabolic profiles in hybrid Pennisetum.

Background: This study investigated the effects of inoculating Lactobacillus parafarraginis alone or in combination with citric acid on the silage quality, microbial community structure, and metabolic characteristics of hybrid Pennisetum. The experiment included three treatments: (1) addition of 10 ml distilled water (CON); (2) addition of 1 × 10 cfu/g L. parafarraginis (LP); (3) addition of 1 × 10 cfu/g L.

Ecotoxicological effects of the neonicotinoid insecticide dinotefuran on springtails (Folsomia candida) at soil residual concentration.

Dinotefuran, a third-generation neonicotinoid insecticide, is widely used in agriculture production due to its excellent insecticidal efficacy. Considering its persistence and high toxicity in soil, it is essential to evaluate its low-dose toxic effects on non-target soil organisms such as the springtail (Folsomia candida). The results revealed that the 7-day half lethal concentration (7d-LC) of dinotefuran contact toxicity to springtails was 0.

Synthesis of Highly Functionalized Indolizines via NIS-Promoted Spiroannulation/Ring-Opening Aromatization of Alkylidene Oxindoles with 2-(Pyridin-2-yl)acetate Derivatives.

A novel NIS-promoted domino reaction of alkylidene oxindoles with 2-(pyridin-2-yl)acetate derivatives has been established, enabling the efficient and straightforward synthesis of a vast variety of highly functionalized indolizines via sequential spiroannulation and ring-opening aromatization processes. The protocol features mild reaction conditions, broad substrate scope, high efficiency, scalability, and applicability for the preparation of CF-containing indolizines. Furthermore, the functional groups in the indolizine framework provide the feasibility for follow-up derivatization.

Evaluating the anti-inflammatory and antioxidant efficacy of complementary and alternative medicines (CAM) used for management of inflammatory bowel disease: a comprehensive review.

Inflammatory bowel disease (IBD) is a chronic autoimmune condition whose pathogenesis has not been fully elucidated, and current treatments are not definitive and often carry several side effects. The Complementary and Alternative Medicine (CAM) offers a new approach to conventional medicine. However, their clinical application and mechanisms remain limited.

Prevalence, Awareness, Treatment, and Control of Diabetes Among 0.98 Million Patients With Stroke/TIA in China: Insights From a Nationwide Cohort Study.

Background: A comprehensive epidemiological investigation of the coexistence between diabetes and stroke/TIA in China is urged.

Methods: Data from the Chinese Stroke Center Alliance program, a nationwide multi-center registry study, were used to detect the prevalence, awareness, treatment, and control of diabetes among stroke/TIA. The distribution of diagnosed and undiagnosed diabetes and prediabetes among stroke/TIA patients was investigated, the medical care around diabetes and their respective risk predictors were analyzed, and the association of all above diabetes characteristics with in-hospital death was evaluated using multi-variable Cox regression models.

Stigma toward people living with HIV among healthcare providers in midwifery hospitals in Shenzhen, China from 2020 to 2023.

Shenzhen, a leading city in China's Elimination of Mother-to-Child Transmission (EMTCT) Programme, implemented effective practices to reduce HIV-related stigma and officially launched a comprehensive work plan in 2021. This study assessed the trend of HIV-related stigma in Shenzhen's midwifery hospitals by comparing two surveys of healthcare providers (HCPs) conducted in 2020 and 2023. The study included 2705 HCPs and used an adapted 15-item HIV-related stigma scale.

USP48 inhibits colorectal cancer progression and promotes M1-like macrophage polarization by stabilizing TAK1.

Ubiquitination and deubiquitination have emerged as pivotal regulators of the development of colorectal cancer (CRC). However, the precise role of USP48 in CRC tumorigenesis is poorly understood. In this study, immunohistochemistry, protein blotting, MTT assays, plate cloning, scratch assays, transwell assays, and Hoechst 33258 staining were utilized to assess the expression level of USP48 and its involvement in CRC.

Immobilization of Proteinase K into PLA for self-biodegradable.

Biodegradable plastics offer a promising alternative to petroleum-based plastics for alleviating environmental pressure. Biodegradable plastics have a long degradation cycle time and require strict degradation conditions. Enzymatic degradation represents a highly effective approach for enhancing the degradation efficiency of biodegradable plastics.

ACAT1-Mediated ME2 Acetylation Drives Chemoresistance in Ovarian Cancer by Linking Glutaminolysis to Lactate Production.

Lactate derived from aerobic glycolysis is crucial for DNA damage repair and chemoresistance. Nevertheless, it is frequently noted that cancer cells depend on glutaminolysis to replenish essential metabolites. Whether and how glutaminolysis might enhance lactate production and facilitate DNA repair in cancer cells remains unknown.

Sex differences in cardiac fibrosis induced by gestational exposure to polystyrene nanoplastics in mice offspring.

The increasing accumulation of plastics in the environment has raised concerns regarding their potential health hazards. Nanoplastics (NPs) can get transported across the placental barrier, resulting in detrimental effects on developing offspring. To date, the effects of maternal exposure to NPs during pregnancy on the cardiac toxicity in adult offspring have not been conclusively evaluated.

The controllable fabrication of AIE gold nanoclusters and utilizing as portable ultrasensitive detection sensor for silver ions via smartphone.

Heavy metal pollution is life-threatening, the detection of heavy metals is crucial to human health and environment. In this work, AIE featured LA-stabilized gold nanoclusters (NL-AuNCs) were designed and fabricated by modulating precursors in various reaction conditions, and utilized as an efficient fluorescent sensor for portable detecting Ag with high sensitivity and selectivity. The NL-AuNCs exhibited intense red fluorescence at 625 nm via the secondary reducing agent N-acetyl-L-cysteine (NAC), achieving a quantum yield (QY) of 15.

Changes in quality, endogenous enzyme activities, and their relationships during post-harvest storage of Phlebopus portentosus- an edible fungus.

The postharvest quality of Phlebopus portentosus, a valuable edible fungus, is highly susceptible to spoilage due to endogenous enzymes during storage. This study investigated changes in firmness, weight loss, color, browning degree, malondialdehyde concentration, oxidation level, enzyme activities, and volatile compounds in P. portentosus during storage at 4 °C and 25 °C, alongside their interrelationships.

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU-EMRE Assembly.

The mitochondrial calcium uniporter (MCU) complex mediates Ca entry into mitochondria, which plays a crucial role in regulating cellular energy metabolism and apoptosis. Dysregulation of MCU is implicated in various diseases, such as neurodegenerative disorders, cardiac diseases, and cancer. Despite its importance, developing specific and clinically viable MCU inhibitors is challenging.

Machine learning-based plasma metabolomics for improved cirrhosis risk stratification.

Background: Cirrhosis is a leading cause of mortality in patients with chronic liver disease (CLD). The rapid development of metabolomic technologies has enabled the capture of metabolic changes related to the progression of cirrhosis.

Methods: This study used proton nuclear magnetic resonance (1 H-NMR) serum metabolomics data from the UK Biobank (UKB) and employed elastic net-regularized Cox proportional hazards models to explore the role of metabolomics in cirrhosis risk stratification in patients with CLD.

Impaired hippocampal neurogenesis associated with regulatory ceRNA network in a mouse model of postoperative cognitive dysfunction.

Background: Postoperative cognitive dysfunction (POCD) represents a post-surgical complication that features progressive cognitive impairment and memory loss, often occurring in elderly patients. This study aimed to investigate the potential biological mechanisms underlying POCD.

Methods: Male C57BL/6 mice (2 and 17 months old) were randomly assigned to surgery or control groups.

Causal relationship between dietary habits and Alzheimer's disease risk: a univariable and multivariable Mendelian randomization study.

: The objective of this study was to evaluate the causal link between dietary habits and Alzheimer's disease (AD), utilizing a two-sample Mendelian randomization approach. : In this research, we utilized two-sample Mendelian randomization (MR) analyses in tandem with genome-wide association study (GWAS) data to comprehensively assess the causal link between 17 dietary habits and the risk of AD. To ensure the robustness of the findings, both univariate Mendelian randomization (UVMR) and multivariate Mendelian randomization (MVMR) methods were utilized.

IL-10RA promotes lung cancer cell proliferation by increasing fatty acid oxidation via STAT3 signaling pathway.

Metabolic reprogramming in tumor cells plays a crucial role in promoting cell proliferation and metastasis, and is currently recognized as a significant marker of tumor progression. Interleukin-10 receptor subunit alpha (IL-10RA), a member of the type II cytokine receptor family, is predominantly expressed on macrophages and T cells and plays a crucial role in regulating immune cell metabolism and immune response. However, its role in the energy metabolic pathways of tumor cells remains unclear.

Two new phenolic constituents from the Busch roots.

Two new phenolic compounds aconitol A () and B (), together with three known compounds including one phenolic constituent () and two diterpenoid alkaloids (-), were isolated from the roots of . Their structures were assigned by HRESIMS, extensive spectral methods and compared with literature data. All obtained compounds (-) were tested for their inhibitory activity against NO production in LPS-activated RAW 264.

Endpoint-aware audio-visual speech enhancement utilizing dynamic weight modulation based on SNR estimation.

Integrating visual features has been proven effective for deep learning-based speech quality enhancement, particularly in highly noisy environments. However, these models may suffer from redundant information, resulting in performance deterioration when the signal-to-noise ratio (SNR) is relatively high. Real-world noisy scenarios typically exhibit widely varying noise levels.

In Situ Analysis of Plant Tissue Using Arc iKnife Ionization Mass Spectrometry.

This study developed a portable arc iKnife ionization mass spectrometry (AII-MS) technique integrating a surgical knife with low-temperature arc plasma to interact with plant tissues. The thermal energy from the arc plasma induces the sputtering of water-containing plant tissues, leading to the formation of aerosols. These aerosols are then charged by plasma-generated ions, producing charged microdroplets that are ultimately detected by a mass spectrometer.

Solvent-Regulated Cyclization of Arylidene Isoxazolones with Amidines for Regiodivergent Synthesis of 4- and 5-Acylimidazoles.

-Iodosuccinimide-promoted cascade reactions of arylidene isoxazolones with amidines in -xylene were accomplished, affording 5-acylimidazoles in good to excellent yields. Interestingly, when the reactions were performed by employing acetonitrile as the solvent, 4-acylimidazoles were efficiently obtained. Mechanistic studies indicate that the formation of imidazolyl and acyl moieties may undergo a spiroannulation-ring opening aromatization-hydrolysis cascade reaction sequence.

Novel inflammatory markers in intracerebral hemorrhage: Results from Olink proteomics analysis.

Inflammation is a crucial factor in intracerebral hemorrhage (ICH) pathophysiology, but specific inflammatory biomarkers in ICH patients remain unclear. This study aimed to identify novel circulating inflammatory biomarkers for improved ICH prediction and diagnosis. We profiled expression levels of 92 cardiovascular disease related proteins in plasma from 26 matched ICH patients and controls using Olink technology.

Using platelet concentrates to treat maxillofacial tissue lesions.

Objectives: Platelet concentrates (PCs), which are blood products that are abundant in platelets and growth factors, have become pivotal in treating maxillofacial tissue lesions due to their capacity for promoting bone and soft tissue recovery. This review will provide some recent progress of the use of platelet concentrates to treat lesions on maxillofacial tissues.

Subjects: We reviewed the mechanisms by which PCs promote wound healing and tissue recovery and summarized the application of PCs in the treatment of lesions on maxillofacial tissues, including medication-related osteonecrosis of the jaw, post-extraction wound healing, implant surgery, temporomandibular joint diseases, and periodontal tissue restoration.