Publications by authors named "Sintia Teichman"
Article Synopsis
- Recent thymic emigrant (RTE) cells are immature T cells that mature outside the thymus and play a key role in immune responses, especially in early life and after lymphodepletion.
- Researchers used RBPJind mice to examine the stages of RTE maturation, highlighting a specific intermediate stage that prefers producing IL-17 over IFN-γ.
- The study found that Notch signaling is crucial for the maturation and function of these intermediate T cells; without it, their ability to contribute to inflammatory responses, like colitis, is significantly impaired.
T cells are pivotal effectors of the immune system and can be harnessed as therapeutics for regenerative medicine and cancer immunotherapy. An unmet challenge in the field is the development of a clinically relevant system that is readily scalable to generate large numbers of T-lineage cells from hematopoietic stem/progenitor cells (HSPCs). Here, we report a stromal cell-free, microbead-based approach that supports the efficient in vitro development of both human progenitor T (proT) cells and T-lineage cells from CD34cells sourced from cord blood, GCSF-mobilized peripheral blood, and pluripotent stem cells (PSCs).
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