[Analgesia and anesthesia in the prehospital stage of mechanical trauma].

The work reviews the results of the use of various analgesics and anesthetics in 965 outpatients with mechanical traumas, including 340 ones with shock and blood loss. Central hemodynamics has been studied in 60 patients during anesthesia with lexir, ketamine, sodium hydroxybutyrate, respiratory function has been assessed in 20 patients. The results have been confirmed experimentally on 160 rats, 50 cats, and 40 dogs.

[Effect of benzodiazepines on interneuronal transmission in afferent systems and their antagonism with Ro 15-1788].

The tranquilizers diazepam and phenazepam inhibited the responses in ventrolateral columns and segmental polysynaptic potentials in the spinal cord evoked by electrical stimulation of somatic nerves. The drugs also inhibited the responses in somavisceral and associative areas of the brain cortex, in specific, associative and nonspecific nuclei of the thalamus and mesencephalic reticular formation evoked by stimulation of visceral and somatic nerves as well as by sound and photostimulation. Diazepam and phenazepam inhibited cortical responses to single and pair stimulation of the fibers of thalamocortical radiation.

[Stress analgesia in experimental burn shock].

Experiments with curarized and slightly anesthetised adult cats with burn shock have demonstrated pronounced depression of excitation transmission in associative and nonspecific afferent systems during somatic, sound and light stimulation. Effects controlling the activity of the cardiovascular system were facilitated in efferent systems. In white rats, burn shock led to an increase in the somatic and visceral pain threshold during the first 5 days.

[Effect of tranquilizers on impulse conduction in the afferent pathways of visceral nerves].

Experiments on pyrolaxon-immobilized cats evidence that diazepam produces depression of evoked potentials in the specific, nonspecific and associative brain structures upon an electric stimulation of the visceral and somatic nerves, and also with accoustic and photostimulation; Meprotan (meprobamate) in doses of 40-100 mg/kg neither changes nor increases, and in doses of 100-150 mg/kg, reduces the amplitude of evoked potentials and at the sme time forces down the arterial pressure. Amizyl (benactyzine) inhibits the potentials evoked by stimulation of the vagus. The amplitude of responses arising on stimulation of the inferior cardiac, celiac and sciatic nerves, and also with acoustic and photostimulation neither changes nor increases.

[Experience with the use of viadril anesthesia].

Based on experimental and clinical findings the authors concluded that a combination of viadril with neuroleptanalgesics shows a number of advantages over purely viadril anesthesia or its combination with other drugs for inhalation and intravenous anesthesia. The technic of thalmonal-viadril anesthesia is reported.

[Effect of narcotic analgesics on impulse conduction along the afferent pathways of visceral nerves].

Experiments were conducted on chloralose-anesthetized cats. The action of morphine and promedol upon the potentials of the cortical and subcortical structures occurring after the visceral nerve stimulation was studied. Morphine proved to depress the potentials evoked by stimulation of the inferior cardiac and vagus nerves, in the specific, associative and nonspecific structures of the brain; promedol produced an analogous effect.