Publications by authors named "Sinisa S Babovic"

: Foot deformities are the basis of numerous disorders of the locomotor system. An optimized method of classification of foot deformities would enable an objective identification of the type of deformity since the current assessment methods do not show an optimal level of objectivity and reliability. The acquired results would enable an individual approach to the treatment of patients with foot deformities.

View Article and Find Full Text PDF

Background: According to the neurodevelopmental theory, brain structuring early markers could be seen in different body parts as minor physical anomalies. Alongside minor physical anomalies, handedness and index to ring finger ratio are brain development indicators, specifically brain lateralization. Studies are consentient about the association of these findings with schizophrenia, though there is inconsistency about individual anatomical regions' contribution.

View Article and Find Full Text PDF

Background: Sex hormones are known to have some influence on nasal functions, but their effect on the decongestive response of the nasal mucosa during menstrual cycle is still undetermined.

Objectives: The aim of this study was to examine the nasal physiology, the interconnectedness of olfactory and respiratory nasal function and the decongestive response of the nasal mucosa during menstrual cycle.

Methods: This study included 101 healthy women aged 23.

View Article and Find Full Text PDF

Introduction: By examining the production of c-Fos protein, we analyzed the response to the ischemic attack in different brain tissue, two of which are regions of the limbic system: the anterior amygdaloid area and nc. accumbens.

Material And Methods: We used the model of rat brain ischemia--four-vessel occlusion, and Pulsinelli's method.

View Article and Find Full Text PDF

The caudate nucleus, as a part of the striatum (neostriatum or dorsal striatum), is involved in the control of cognitive, motor and limbic functions. The majority of the caudate nucleus cells are projection spiny neurons, whose activity is determined by excitatory inputs from the cortex, thalamus, globus pallidus and brainstem. A qualitative analysis of human caudate nucleus neurons involves the description of the structure and features of cells, and accordingly, their classification into an appropriate type.

View Article and Find Full Text PDF

Introduction: This study used the immunohistochemical method to follow the expression of cytoplasmatic protein somatostanin in the course of ischemia of rat brain. The aim of the study was to define all the areas of expression of somatostain and to show the protein distribution on the map.

Material And Methods: All the sections of telencephalon, diencephalon and midbrain were studied in resistant, and transitory ischemia, which enabled us to observe the reaction of neurons to an ischemic attack or to repeated attacks.

View Article and Find Full Text PDF

The aim of this study was to define all the areas of changes in expression of nuclear c-Fos protein (c-Fos), cytoplasmic somatostatin (SS) and neuropeptide Y (NPY) in rat brain during experimental ischemia. Using the immunohistochemical method, brain mapping (based on the atlas by Paxinos & Watson) of immunoreactivity for c-Fos, SS and NPY in 39 rats, was studied in telencephalon, diencephalon and midbrain after resistant and transitory ischemia. The first experimental group (R group) was exposed to resistant ischemia by occlusion (10 minutes) of four vessels according to the Pulsinelli method.

View Article and Find Full Text PDF

Introduction: The immunohistochemical method was used to follow the expression ofneuropeptide Y in the course of pre ischemia of the rat brain. The aim of the study was to define all the areas of expression of this protein, show their localization, their map of distribution and histological types.

Material And Methods: All the sections of telencephalon, diencephalon and midbrain were studied in resistant, and transitory ischemia, which enabled us to observe the reaction of neurons to an ischemic attack or to repeated attacks.

View Article and Find Full Text PDF

When defining obesity body mass index (BMI) has been used as the main criterion. However it indicates only the nutritional status, whereas body fat demonstrates the real body composition picture. This study aimed at analyzing the relationship between nutritional status and adiposity in the population of 2284 Serbian children (1217 boys and 1067 girls).

View Article and Find Full Text PDF

Background/aim: The role of the dentate nucleus is to coordinate input information coming from the lower olivary complex and various parts of the brainstem of the spinal marrow with the output information from the cerebellar cortex. To better understand functions and relations of the dentate nucleus it is highly important to study its development process. The aim of this study was to determine a possible mathematical model of decrease in neuronal numerical density of the human nucleus dentatus at different stages of development.

View Article and Find Full Text PDF

Introduction: The significance of this research in terms of structure and biochemical processes in PVN contributes to further understanding of vital physiological processes from delivery and stress to delicate chemical processes that keep the hypothalamo-hypophysial axis in balance.

Conclusion: Comparative studies of the human hypothalamus with the hypothalamus of other mammals enable further research, especially pharmacological and physiological ones. These are made possible with the aid of highly sophisticated equipment for examination of neurophysiological features of the brain.

View Article and Find Full Text PDF

Introduction: The aim of this study was to identify the critical periods in the development of the human dentate nucleus in fetuses of different gestational ages and in one newborn brain.

Material And Methods: The fetal brains were fixed in alcohol-formalin-acetic acid, embedded in paraffin, cut into 30 micro sections, and stained with cresyl violet. The sections were examined by light microscopy.

View Article and Find Full Text PDF

Introduction: The paper deals with the embryonic development of human hypothalamus at the end of the first and during the second trimesters of gestation. Bearing in mind that the mammal brain, as an entity, develops from the prosencephalic, mesencephalic and rhombencephalic vesicles, which are noticeable in the cranial portion of the neural tube in the 4th week of gestation, and that diencephalon is manifested in the eye vesicle at the same gestational age, authors presented the neuronal secretory activity in that period.

Secretory Activity Of Hypothalamic Neurons: The secretory activity of both neurons and hypothalamic nuclei, as well as their maturation, were followed-up by certain immunohistochemical and immunoradiological methods based on structural identification of some factors (primarily protein molecules), which made it possible to determine the specificity of secretory activity of hypothalamic nuclei (ex.

View Article and Find Full Text PDF

Introduction: We have attempted to identify which parts of the brain react to ischemic attack using the four-vessel occlusion model in rats.

Material And Methods: We have monitored the expression of c-fos protein in the parietal cortex (R3 and T3) and in the olfactory tubercle (R4 and T4), regions which are supplied with blood by different arteries. The four-vessel occlusion was performed using the Pulsinelli's method and rats were divided into two groups: total ischemia (ligation of four blood vessels or coagulation of the vertebral artheries with bilateral ligation of carotid arteries - R group) and transient ischemic attack (ligation of four blood vessels or coagulation of the vertebral arteries with bilateral repeated ligation of carotid arteries - T group of rats, the so-called preconditioned group).

View Article and Find Full Text PDF

Introduction: Catecholamines are chemical compounds which play an important role as neurotransmitters in many vital functions of the organism. The paper presents a short survey of their biosynthesis, disintegration andfunctions, with respect to the neuroanatomical location of cell groups which contain these compounds.

Catecholamines In The Human Hypothalamus: Because the authors were most interested in the behavior of catecholamines in the diencephalon, particularly in the hypothalamus, they focussed their attention on cells secreting catecholamines (dopamine, noradrenaline, adrenaline, octopamine).

View Article and Find Full Text PDF

The aim of this study was to shed more light on the developmental characteristics of human paraventricular nucleus (PVN) and hypothalamus in general, using modern immunohistochemical techniques to detect the activity of tyrosine hydroxylase (TH) in the synthesis of catecholamine (CA). Fetal brains were examined at 12, 16, 20 and 23 weeks gestation. Immunohistochemical staining used for sections is a qualitative method for detection and distribution of the chosen protein.

View Article and Find Full Text PDF