[Biological action of 239Pu during intake by inhalation and complexon therapy with Zn or Ca DTPA under experimental conditions].

The authors described the effect of substantial amounts of plutonium nitrate administered to rats by inhalation in the presence of Zn- or CaDTPA-complexon therapy for 2 months. A 2-fold decrease of absorbed doses in the lung, a 3-fold decrease in the skeleton and a 4-fold decrease in the liver were shown. The mean life of the treated animals was considerably raised.

[Behavior and biological action of large amounts of 239Pu following intramuscular administration in rats undergoing long-term therapy with Zn- and Ca-DTPA].

The authors submit the results of the studies of the influence of large amounts of 239Pu, administered to rats via stab wounds, and subsequent treatment there of with clinical doses of Zn- and Ca-DTPA for two months. It is shown that the absorbed doses considerably decrease and the average life of treated rats increases; the incidence of malignant tumors does not change after the treatment with Ca-DTPA.

[Effect of Na3Zn- and Na3Ca-DTPA on the behavior and biological action of 239Pu on rats].

The effect of a complexon therapy scheme including early (in 1 h) administration of Na3Ca DTPA and subsequent (in 1 day) administration of Na3Zn DTPA or Na3Ca DTPA at a dose of 25 mu Cimol/kg/day by three 2-week courses (5 times a week) with 2-week interruptions was studied in experiments on 541 male rats after intraperitoneal administration of 239Pu citrate complex (95 kBq/kg). The treatment resulted in a 3-fold lessening of the content of 239Pu and absorbed doses in the skeleton, a significant prolongation of the mean survival time (MST) from 452 to 593 days (Na3Zn DTPA) and 643 days (Na3Ca DTPA), and in a decrease of the osteosarcoma incidence from 76.4 to 32.

[Behavior and biological action of 239Pu administered intramuscularly during complexon therapy].

With intramuscular injection of 239Pu nitrate the radionuclide content of the rat skeleton was higher, and at the site of injection, lower, than with injection of a polymer plutonium. The animals developed osteosarcomas (nitrate greater than polymer), and at the site of trauma, fibrosarcomas (nitrate less than polymer). After a complexon therapy the dose accretion in the skeleton and liver diminished, the life span increased, and the incidence of sarcomas decreased.