Publications by authors named "Sini-Pauliina Juopperi"
Background: Phospholipase C gamma 2, proline 522 to arginine (PLCγ2-P522R) is a protective variant that reduces the risk of Alzheimer's disease (AD). Recently, it was shown to mitigate β-amyloid pathology in a 5XFAD mouse model of AD. Here, we investigated the protective functions of the PLCγ2-P522R variant in a less aggressive APP/PS1 mouse model of AD and assessed the underlying cellular mechanisms using mouse and human microglial models.
View Article and Find Full Text PDFGenetic variants in TMEM106B, coding for a transmembrane protein of unknown function, have been identified as critical genetic modulators in various neurodegenerative diseases with a strong effect in patients with frontotemporal degeneration. The luminal domain of TMEM106B can form amyloid-like fibrils upon proteolysis. Whether this luminal domain is generated under physiological conditions and which protease(s) are involved in shedding remain unclear.
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- Neuropathologic changes associated with Alzheimer's disease, like Aβ accumulation and neuroinflammation, are commonly found in the brains of normal pressure hydrocephalus patients.
- Researchers developed a deep learning platform to analyze Aβ levels and microglia surrounding Aβ plaques in cortical biopsies from 120 patients who underwent shunting.
- The study found that higher Aβ presence was linked to worse cognitive outcomes, such as dementia and memory impairment, whereas the density of surrounding microglia had no correlation to cognitive decline.