Publications by authors named "Sini Laasanen"
Background: Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib-treated male patients have been reported to have reduced sperm counts. However, the cellular level effects of imatinib and dasatinib on adult male germ cells and germline stem cells (mGSCs) have not been thoroughly investigated.
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- Cancer cells experience significant changes in gene expression and epigenetics, including the abnormal activation of certain tissue-specific genes.
- The RNA helicase DDX4 forms structures similar to germ granules in tumors but not in cultured cancer cells, containing proteins linked to RNA and splicing.
- The absence of DDX4 in cancer cells alters gene expression, reduces cancer growth and invasiveness, and is associated with poorer patient outcomes in certain cancers like head and neck squamous cell carcinoma and advanced prostate cancer.