Potentiation of immune checkpoint blockade with a pH-sensitizer as monitored in two pre-clinical tumor models with acidoCEST MRI.

Background: Tumor acidosis causes resistance to immune checkpoint blockade (ICB). We hypothesized that a "pH-sensitizer" can increase tumor extracellular pH (pHe) and improve tumor control following ICB. We also hypothesized that pHe measured with acidoCEST MRI can predict improved tumor control with ICB.

Application of Bayesian Decision Theory in Detecting Test Fraud.

This article suggests a new approach based on Bayesian decision theory (e.g., Cronbach & Gleser, 1965; Ferguson, 1967) for detection of test fraud.

Visions by WIMIN: Imposter Phenomenon.

The imposter phenomenon (IP) is a destructive set of beliefs, traits, and experiences in which high-achieving individuals fail to internalize their accomplishments and falsely perceive themselves as frauds. IP is a function of underrepresentation and contributes to and perpetuates a cycle of low self-worth, perfectionism, and anxiety, all of which negatively affect job performance and reinforce the IP cycle. Mitigating the deleterious effects of IP requires first naming this phenomenon and recognizing the patterns of IP.

Assessment of fit of item response theory models: A critical review of the status quo and some future directions.

This paper provides a literature review of assessment of fit of item response theory models. Various types of fit procedures for item response theory models are reviewed, with a focus on their advantages and disadvantages. Real data examples are used to demonstrate some of the fit procedures.

Added Value of Subscores for Tests With Polytomous Items.

Test-takers, policymakers, teachers, and institutions are increasingly demanding that testing programs provide more detailed feedback regarding test performance. As a result, there has been a growing interest in the reporting of subscores that potentially provide such detailed feedback. Haberman developed a method based on classical test theory for determining whether a subscore has added value over the total score.

Efficient Corrections for Standardized Person-Fit Statistics.

Many popular person-fit statistics belong to the class of standardized person-fit statistics, T, and are assumed to have a standard normal null distribution. However, in practice, this assumption is incorrect since T is computed using (a) an estimated ability parameter and (b) a finite number of items. Snijders (Psychometrika 66(3):331-342, 2001) developed mean and variance corrections for T to account for the use of an estimated ability parameter.

Effect of PVP Molecular Weights on the Synthesis of Ultrasmall Cus Nanoflakes: Synthesis, Properties, and Potential Application for Phototheranostics.

Copper sulfide nanoparticles (CuS) hold tremendous potential for applications in photothermal therapy (PTT) and photoacoustic imaging (PAI). However, the conventional chemical coprecipitation method often leads to particle agglomeration issues. To overcome this challenge, we utilized polyvinylpyrrolidone (PVP) as a stabilizing agent, resulting in the synthesis of small PVP-CuS nanoparticles named PC10, PCK30, and PC40.

Assessment of fit of the time-varying dynamic partial credit model using the posterior predictive model checking method.

Several new models based on item response theory have recently been suggested to analyse intensive longitudinal data. One of these new models is the time-varying dynamic partial credit model (TV-DPCM; Castro-Alvarez et al., Multivariate Behavioral Research, 2023, 1), which is a combination of the partial credit model and the time-varying autoregressive model.

Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors.

Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) of solid tumors. In the TME, programmed death-ligand 1 (PD-L1) expression on cancer cells is mainly regulated by Interferon-gamma (IFN-γ), which induces T cell exhaustion and enables tumor immune evasion. In this study, we demonstrate that acidosis, a common characteristic of solid tumors, significantly increases IFN-γ-induced PD-L1 expression on aggressive cancer cells, thus promoting immune escape.

Using item scores and response times in person-fit assessment.

The use of joint models for item scores and response times is becoming increasingly popular in educational and psychological testing. In this paper, we propose two new person-fit statistics for such models in order to detect aberrant behaviour. The first statistic is computed by combining two existing person-fit statistics: one for the item scores, and one for the item response times.

In Vitro Modeling as a Tool for Testing Therapeutics for Spinal Muscular Atrophy and IGHMBP2-Related Disorders.

Spinal Muscular Atrophy (SMA) is the leading genetic cause of infant mortality. The most common form of SMA is caused by mutations in the SMN1 gene, located on 5q (SMA). On the other hand, mutations in IGHMBP2 lead to a large disease spectrum with no clear genotype-phenotype correlation, which includes Spinal Muscular Atrophy with Muscular Distress type 1 (SMARD1), an extremely rare form of SMA, and Charcot-Marie-Tooth 2S (CMT2S).

Targeted Double Scoring of Performance Tasks Using a Decision-Theoretic Approach.

Targeted double scoring, or, double scoring of only some (but not all) responses, is used to reduce the burden of scoring performance tasks for several mastery tests (Finkelman, Darby, & Nering, 2008). An approach based on statistical decision theory (e.g.

Mapping Spatiotemporal Heterogeneity in Tumor Profiles by Integrating High-Throughput Imaging and Omics Analysis.

Intratumoral heterogeneity associates with more aggressive disease progression and worse patient outcomes. Understanding the reasons enabling the emergence of such heterogeneity remains incomplete, which restricts our ability to manage it from a therapeutic perspective. Technological advancements such as high-throughput molecular imaging, single-cell omics, and spatial transcriptomics allow recording of patterns of spatiotemporal heterogeneity in a longitudinal manner, thus offering insights into the multiscale dynamics of its evolution.

Assessing organ-level immunoreactivity in a rat model of sepsis using TSPO PET imaging.

There is current need for new approaches to assess/measure organ-level immunoreactivity and ensuing dysfunction in systemic inflammatory response syndrome (SIRS) and sepsis, in order to protect or recover organ function. Using a rat model of systemic sterile inflammatory shock (intravenous LPS administration), we performed PET imaging with a translocator protein (TSPO) tracer, [F]DPA-714, as a biomarker for reactive immunoreactive changes in the brain and peripheral organs. dynamic PET/CT scans showed increased [F]DPA-714 binding in the brain, lungs, liver and bone marrow, 4 hours after LPS injection.

The Standardized S- Statistic for Assessing Item Fit.

The S- statistic (Orlando & Thissen, 2000) is popular among researchers and practitioners who are interested in the assessment of item fit. However, the statistic suffers from the Chernoff-Lehmann problem (Chernoff & Lehmann, 1954) and hence does not have a known asymptotic null distribution. This paper suggests a modified version of the S- statistic that is based on the modified Rao-Robson statistic (Rao & Robson, 1974).

An Investigation Into the Impact of Test Session Disruptions for At-Home Test Administrations.

In response to the closures of test centers worldwide due to the COVID-19 pandemic, several testing programs offered large-scale standardized assessments to examinees remotely. However, due to the varying quality of the performance of personal devices and internet connections, more at-home examinees likely suffered "disruptions" or an interruption in the connectivity to their testing session compared to typical test-center administrations. Disruptions have the potential to adversely affect examinees and lead to fairness or validity issues.

Estimating Probabilities of Passing for Examinees With Incomplete Data in Mastery Tests.

Administrative problems such as computer malfunction and power outage occasionally lead to missing item scores and hence to incomplete data on mastery tests such as the AP and U.S. Medical Licensing examinations.

PET imaging of TSPO expression in immune cells can assess organ-level pathophysiology in high-consequence viral infections.

Ebola virus (EBOV) disease is characterized by lymphopenia, breach in vascular integrity, cytokine storm, and multiorgan failure. The pathophysiology of organ involvement, however, is incompletely understood. Using [18F]-DPA-714 positron emission tomography (PET) imaging targeting the translocator protein (TSPO), an immune cell marker, we sought to characterize the progression of EBOV-associated organ-level pathophysiology in the EBOV Rhesus macaque model.

The Use of Theory of Linear Mixed-Effects Models to Detect Fraudulent Erasures at an Aggregate Level.

Wollack et al. (2015) suggested the erasure detection index (EDI) for detecting fraudulent erasures for individual examinees. Wollack and Eckerly (2017) and Sinharay (2018) extended the index of Wollack et al.

The Lack of Robustness of a Statistic Based on the Neyman-Pearson Lemma to Violations of Its Underlying Assumptions.

Drasgow, Levine, and Zickar (1996) suggested a statistic based on the Neyman-Pearson lemma (NPL; e.g., Lehmann & Romano, 2005, p.

Solution-Blown Poly(hydroxybutyrate) and ε-Poly-l-lysine Submicro- and Microfiber-Based Sustainable Nonwovens with Antimicrobial Activity for Single-Use Applications.

Antimicrobial nonwovens for single use applications (e.g., diapers, sanitary napkins, medical gauze, etc.

Monitoring Immune Activation with Whole-Body Fluorodeoxyglucose-Positron-Emission Tomography in Simian Immunodeficiency Virus-Infected Rhesus Macaques.

This study aimed to assess immune activation in tissues by measuring glucose metabolism with F-fluorodeoxyglucose (FDG) and investigate the associations of various peripheral markers of disease progression with initiation and interruption of combination antiretroviral therapy in SIV-infected rhesus macaques (). Mixed-effect linear models revealed a significant inverse association of peripheral blood CD4 T cell counts ( < 0.01) and a direct association of plasma viral load ( < 0.

Ultrafine PVDF Nanofibers for Filtration of Air-Borne Particulate Matters: A Comprehensive Review.

The ongoing global pandemic has bestowed high priority uponthe separation of air-borne particulate matters (PMs), aerosols, etc. using nonwoven fibrous materials, especially for face masks as a means of personal protection. Although spunbond or meltblown nonwoven materials are amongst the forerunners for polymer microfiber-based face mask or air filter development in mass scale, relatively new process of nonwoven manufacturing such as electrospinning is gaining a lot of momentum amongst the filter membrane manufacturers for its scalability of nanofiber-based filter membrane fabrication.