Revitalizing the Smile: A Case Report on the Modified Apexification Procedure for Discolored Non-Vital Immature Teeth With Periapical Lesions.

Apexification is the process of forming mineralized tissue at the apical portion of a tooth with an incompletely formed root. Although various materials and techniques for the endodontic treatment of such teeth have been employed for some time, selecting the appropriate material remains challenging due to limited literature. This report presents a case that evaluates the efficacy of a modified apexification procedure using mineral trioxide aggregate (MTA), followed by a walking-bleach technique to address discoloration resulting from trauma to anterior teeth.

Comparative Assessment of the Antimicrobial Efficacy of Photoactivated Disinfection Employing Distinct Photosensitizers: A Morphological Analysis Using Scanning Electron Microscopy and Confocal Laser Scanning Microscopy.

Background The complex morphology of the root canal system and bacterial infiltration to greater depths precludes complete debridement by mechanical preparation alone. Despite promising characteristics of photodynamic inactivation (PDI) and different photosensitizers (PSs), there has been limited research on the antibacterial efficacy of chitosan (CS)-based PS combinations for root canal disinfection. We aimed to evaluate and compare the antimicrobial efficacy of photoactivated disinfection (PAD) using two different PSs as an adjunct to final irrigation in root canal treatment.

A Comparative Analysis of the Antimicrobial Efficacy of Nisin in Different Vehicles Against Enterococcus faecalis: An In Vitro Study.

Aim To evaluate and compare the antimicrobial efficacy of nisin in different carriers against . Materials and methods Test materials were divided into four groups of five samples each as follows: group 1 = nisin + 17% ethylenediaminetetraacetic acid (EDTA); group 2 = nisin + 2% chitosan; group 3 = nisin + 2% chlorhexidine; group 4 = nisin + distilled water (control). The antimicrobial effectiveness was assessed using the direct contact method, where a standardized suspension was applied to the test materials.

Platelet-Rich Fibrin: A Self-Derived Biomaterial for Surgical Treatment of a Periapical Lesion.

This case report explores the application of platelet-rich fibrin (PRF) as an autologous biomaterial in the surgical management of a periapical cyst in an 18-year-old female patient. The patient presented with pain, discoloration, and swelling in the maxillary left central incisor region, indicative of an asymptomatic periapical lesion associated with a history of trauma. Despite initial endodontic treatment with calcium hydroxide, the lesion persisted, necessitating surgical intervention.

Advanced Management of Open Apex Utilizing Platelet-Rich Fibrin and Bone Graft As Apical Barriers With Mineral Trioxide Aggregate (MTA) Obturation: A Detailed Case Report.

Management of open apex cases in endodontics poses a significant challenge, especially in immature teeth with necrotic pulps. Traditional apexification techniques have been the mainstay of treatment, aiming to induce the formation of a calcific barrier at the root apex. However, newer approaches incorporating biological materials such as platelet-rich fibrin (PRF) and demineralized bone matrix (DMBM) have emerged as promising alternatives.

Comparative evaluation of the antibacterial efficacy of two experimental calcium silicate-based intracanal medicaments: An study.

Introduction: Success of endodontic treatment relies on minimizing microbial load by chemo-mechanical preparation and intra-canal medication(ICM). Calcium hydroxide based ICMs have known disadvantages. Calcium silicate-based cements(CSC) exhibit antibacterial activity, thus promoting researchers to experiment with their formulations to use them as ICMs.

A quantitative evaluation of the effect of meals on macular thickness in diabetic patients with diabetic macular edema.

Purpose: Central subfoveal thickness measurement is used in a large number of clinical trials to monitor the progression and treatment response of diabetic macular edema (DME) in patients of diabetic retinopathy (DR). Several studies have been carried out to investigate various factors affecting the central subfoveal thickness in order to minimize errors in the testing. We planned a study to investigate the effect of meals on central macular thickness (CMT) in patients with DME and compare that with nondiabetic patients.

Comparative evaluation of antibacterial efficacy of nonsteroidal anti-inflammatory medications and proton-pump inhibitor against : An study.

Aim: The present experimental study was undertaken to evaluate and compare the antimicrobial activity of triple antibiotic paste (TAP), diclofenac, and proton-pump inhibitor (PPI) against the microorganism Enterococcus faecalis.

Materials And Methods: Three medicaments were selected for the study, TAP, diclofenac, and PPI. The experimental groups for the test were as follows: Part 1 - Group 1: TAP, Group 2: diclofenac, and Group 3: PPI; Part 2 - Group 1: TAP + PPI and Group 2: diclofenac + PPI.

Design and development of non-magnetic hierarchical actuator powered by shape memory alloy based bipennate muscle.

Actuators are ubiquitous to generate controlled motion through the application of suitable excitation force or torque to perform various operations in manufacturing and industrial automation. The demands placed on faster, smaller, and efficient actuators drive innovation in actuator development. Shape memory alloy (SMA) based actuators have multiple advantages over conventional actuators, including high power-to-weight ratio.

Sentimental study of CAA by location-based tweets.

As people progressively resort to twitter to express their opinions or to disambiguate their sentiment, it's feasible to analyze the mass opinion to conclude the polarity of the subject at hand using sentiment analysis. Sentiment Analysis (SA) has revolutionized the way information is perceived today. Inspired by this, the work in this paper investigates the much-debated act- the Citizenship Amendment Act (CAA) by analyzing opinionated geo-tagged tweets, manually annotated and cross verified by six annotators.

Management of liver trauma in urban university hospitals in India: an observational multicentre cohort study.

Background: Low- and middle-income countries (LMICs) contribute to 90% of injuries occurring in the world. The liver is one of the commonest organs injured in abdominal trauma. This study aims to highlight the demographic and management profile of liver injury patients, presenting to four urban Indian university hospitals in India.

Radiosensitising Cancer Using Phosphatidylinositol-3-Kinase (PI3K), Protein Kinase B (AKT) or Mammalian Target of Rapamycin (mTOR) Inhibitors.

Radiotherapy is routinely used as a neoadjuvant, adjuvant or palliative treatment in various cancers. There is significant variation in clinical response to radiotherapy with or without traditional chemotherapy. Patients with a good response to radiotherapy demonstrate better clinical outcomes universally across different cancers.

Infarcted accessory spleen masquerading as a mesenteric cyst.

An accessory spleen is a rare entity which is usually asymptomatic. When symptomatic, it presents as an acute abdomen, with either torsion, rupture or haemorrhage. We present the case of a 20-year-old man who presented with chronic lower abdominal pain since 3 months and a lump in the left lower quadrant.

Useful pharmacodynamic endpoints in children: selection, measurement, and next steps.

Pharmacodynamic (PD) endpoints are essential for establishing the benefit-to-risk ratio for therapeutic interventions in children and neonates. This article discusses the selection of an appropriate measure of response, the PD endpoint, which is a critical methodological step in designing pediatric efficacy and safety studies. We provide an overview of existing guidance on the choice of PD endpoints in pediatric clinical research.

WATCH Scrubs: a video observational study of workplace-based learning at Sacred Heart Hospital.

Context: Workplace-based learning remains the cornerstone of clinical training. Teaching in the clinical environment promotes active engagement as trainees are required to combine their competencies (e.g.

A Bibliometric Analysis of the 100 Most-cited Articles in Rhinoplasty.

Introduction: Citation analysis aims to quantify the importance and influence of a published article within its field. We performed a bibliometric analysis to determine the most highly cited articles within rhinoplasty and their impact on current practice.

Methods: The 100 most-cited articles relating to rhinoplasty, between and inclusive of January 1864 to September 2015, were extracted from Web of Science in October 2015.

Marjolin's ulcer: a rare entity with a call for early diagnosis.

Marjolin's ulcer (MU) is an umbrella term covering squamous cell carcinoma (SCC), basal cell carcinoma and malignant melanoma that develop in chronic wounds, sinuses or scars. Cutaneous (non-MU) SCC is related to excessive sun-exposure, with Fitzpatrick skin types I and II being more susceptible. Radiation, genetic disorders (eg, Xeroderma pigmentosum) and immunosuppression, are other important risk factors often involved in the development of cutaneous malignancies and may also be involved in the development of MU.

Twelve tips for medical students to maximise learning in theatre.

Background: Introduction into the clinical environment can be a daunting experience for medical students, especially in the operating theatre. Prior knowledge of how to prepare for theatre and cope with surgical placements is advantageous, as learning opportunities can be maximised from the start.

Aim: This article provides medical students with 12 tips devised to help make the most out of their initial theatre placements.

Peer-teaching of evidence-based medicine.

Background: Many medical schools teach the principles of evidence-based medicine (EBM) as part of their undergraduate curriculum. Medical students perceive that EBM is valuable to their undergraduate and postgraduate career. Students may experience barriers to applying EBM principles, especially when searching for evidence or identifying high-quality resources.

A national study of the processes and outcomes of paediatric formulary applications in Australia.

Objective: To evaluate the processes by which pharmaceuticals are added to the formularies of Australian paediatric hospitals.

Design: Descriptive study of the processes and outcomes of all submissions to Australian paediatric hospital drug and therapeutics committees from 1 July 2010 to 31 December 2011.

Setting: All eight tertiary paediatric hospitals in Australia.

Risk of bias in randomized trials of pharmacological interventions in children and adults.

Objective: To determine whether randomized controlled trials of pharmacologic interventions in children are more likely to be biased than similar trials in adults.

Study Design: Trials involving only children and published in MEDLINE between January 2008 and October 2009 (n=100) were randomly selected and matched, by drug class and therapeutic area, with a similar trial completed in adults. The Cochrane risk of bias tool was used to compare the pediatric and adult trials.