Publications by authors named "Sinh Duy Nguyen"
Liquid biopsy uncovers distinct patterns of DNA methylation and copy number changes in NSCLC patients with different EGFR-TKI resistant mutations.
Hoai-Nghia Nguyen Ngoc-Phuong Thi Cao Thien-Chi Van Nguyen Khang Nguyen Duy Le Dat Thanh Nguyen Quynh-Tho Thi Nguyen Thai-Hoa Thi Nguyen Chu Van Nguyen Mai-Lan Thi Nguyen Trieu Vu Nguyen Luan Thanh Nguyen Sinh Duy Nguyen
Sci Rep
August 2021
Article Synopsis
- Targeted therapy using tyrosine kinase inhibitors (TKI) can improve survival rates for many patients with non-small cell lung cancer (NSCLC), but resistance to these treatments often develops.
- A study analyzed the genetic and epigenetic changes in 122 Vietnamese NSCLC patients experiencing resistance to TKI therapy, finding that 41.8% had specific resistance mutations, particularly in the EGFR gene.
- The research highlighted that the level of genome-wide hypomethylation was linked to how long patients responded to TKI, suggesting that liquid biopsies can help understand TKI resistance mechanisms and inform future treatment strategies.