Demystifying furan formation in foods: Implications for human health, detection, and control measures: A review.

Furan (C₄H₄O), an unintended hazardous compound, is formed in various thermally processed foods through multiple pathways, raising concerns due to its potential carcinogenicity in humans. The aim of this comprehensive review was to synthesize and evaluate the latest research on furan, from its formation by different precursors to its presence in diverse food matrices, as well as the emerging methods for its detection and mitigation. Emphasizing the toxicity of furan, it explored evidence from in vitro and in vivo studies, including reproductive toxicity, carcinogenic effects, and related biomarkers.

Unveiling the Potential of Natural Resources-Derived Therapeutics for Improved Malaria Management: Computational to Experimental Studies.

Malaria kills millions of people annually, and it is one of the major causes of preventable mortality in the world. Of the different plasmodium species that induce malaria, Plasmodium falciparum and Plasmodium vivax account for the most severe form of malarial disease in humans. This review focuses on understanding preventive measures, mutation-based disease evolution, malaria-related biomarkers, and potential plant bioactive components for the treatment and management of malaria.

Correlation of distance walked in audio signal-modified shuttle walk test with six-minute walk test.

The literature review suggested that the audio signal-modified shuttle walk test (SWTSR) was equally reliable and valid when compared to the conventional shuttle walk test. A comparison of SWTSR with the six-minute walk test (6MWT), which is considered the gold standard in walk tests, allowed us to evaluate the SWTSR and determine its validity and reliability as an alternative or supplement to the 6MWT. The objective of this study was to determine the correlation between the distances walked during a SWTSR and the 6MWT in healthy, normal adults.

Frictional Performance of Geometrically Modified Footwear Outsoles with Obliquely Oriented Tread Patterns.

OCCUPATIONAL APPLICATIONSWe systematically examined the effect of obliquely-oriented shoe tread channels on traction performance, by manipulating tread angle, thickness, and gap width across 24 outsole designs. Through robotic slipping tribotesting and computational fluid dynamics modeling, outsoles with a tread inclination angle of 75 and 105 degrees, 2 mm tread thickness, and 5 mm gap width exhibited superior dry and wet traction. This work introduces experimental and computational techniques, offering potential for footwear manufacturers and those who prefer formal shoes to understand the effect of designs on the slip-resistance of a footwear for better safety.

Post-procedure pain in preterm neonates undergoing retinopathy of prematurity (ROP) screening: a prospective cohort study.

Objective: To evaluate the pain intensity in preterm infants during 48 h post retinopathy of prematurity (ROP) screening by binocular fundoscopy.

Design: Prospective cohort study.

Settings: Level-III-NICU in India.

Multisystem inflammatory syndrome in adults hospitalizations in the United States; evaluating patient characteristics, COVID-19 associations, and mortality.

Introduction: Multisystem inflammatory syndrome in adults (MIS-A) is thought to be closely linked with COVID-19 infection. This study aims to elucidate the demographics and clinical characteristics of MIS-A, aiding in timely diagnosis and management.

Methods: Utilizing the National Inpatient Sample (NIS) database (2021), patients were stratified into MIS-A and non-MIS-A groups.

Developing a Canadian artificial intelligence medical curriculum using a Delphi study.

The integration of artificial intelligence (AI) education into medical curricula is critical for preparing future healthcare professionals. This research employed the Delphi method to establish an expert-based AI curriculum for Canadian undergraduate medical students. A panel of 18 experts in health and AI across Canada participated in three rounds of surveys to determine essential AI learning competencies.

Rights-based reproductive services in medical schools in Rajasthan, Gujarat and Chandigarh, India: baseline findings of mixed-methods implementation research.

Introduction: There is a need to assess and strengthen reproductive rights-based family planning and abortion services in Indian medical schools that play a key role in medical education and service delivery. This study presents the findings of baseline assessment across nine schools in two states and one union territory with objective to assess, identify the gaps and improve the status of reproductive rights and evidence-based family planning and abortion services in Indian medical schools.

Methods: A convergent parallel mixed methods study was conducted in nine medical schools in Rajasthan, Gujarat, and Chandigarh a Union territory in India from October 2018 to June 2019.

The Association of Serum Fibrinogen Levels With the Severity of Primary Postpartum Hemorrhage: A Prospective Study.

Introduction: Postpartum hemorrhage (PPH) remains a major cause of maternal mortality and morbidity worldwide. Coagulation disorders are a major risk factor for PPH that have not been studied adequately. Fibrinogen, a plasma glycoprotein, is integral to hemostasis and is involved in the final process of the coagulation cascade.

An integrated bioinformatics approach to early diagnosis, prognosis and therapeutics of non-small-cell lung cancer.

Non-small-cell lung cancer (NSCLC) is one of the most deadly tumors characterized by poor survival rates. Advances in therapeutics and precise identification of biomarkers can potentially reduce the mortality rate. Thus, this study aimed to identify a set of common and stable gene biomarkers through integrated bioinformatics approaches that might be effective for NSCLC early diagnosis, prognosis, and therapies.

Circadian desynchrony in early life leads to enduring autistic-like behavioral changes in adulthood.

Circadian rhythm regulates a variety of biological processes in almost all living organisms. Modern lifestyles, e.g.

Clinical profile, risk factors, disease severity, and outcome for COVID-19 disease in patients with tuberculosis on treatment under the National Tuberculosis Elimination Program: a cohort of 1400 patients.

COVID-19 affected millions of people worldwide, and tuberculosis (TB) continues to affect millions of people each year. The combined pandemic of COVID-19 and TB had a catastrophic effect on healthcare policies and healthcare setups around the globe. The clinical profile and factors affecting the outcome of COVID-19 disease in TB patients on treatment in field conditions have not been studied in detail.

Insights on therapeutic approaches of natural anti-Alzheimer's agents in the management of Alzheimer's disease: A future perspective.

In the current scenario, Alzheimer's disease is a complex, challenging, and arduous health issue, and its prevalence, together with comorbidities, is accelerating around the universe. Alzheimer's disease is becoming a primary concern that significantly impacts an individual's status in life. The traditional treatment of Alzheimer's disease includes some synthetic drugs, which have numerous dangerous side effects, a high risk of recurrence, lower bioavailability, and limited treatment.

Esthetic preferences of orthodontists, general dentists, and laypersons for Indian facial profiles: A cross-sectional study.

Disparity in the esthetic perceptions between a patient and clinician could result in patient dissatisfaction with orthodontic treatment outcomes. The aim of this study was to compare the perceptions of a group of orthodontists, general dentists, and laypersons about the attractiveness of Indian facial profiles. In this study, a male and a female participants' photographs and lateral cephalograms were digitally manipulated by inserting them into Dolphin software; we considered four soft tissue parameters at a nasolabial angle, upper lip E-line, lower lip E-line, and pg-pg', so that 20 profiles were created for each model.

Chromobacterium indicum sp. nov., a Pigment-Producing Bacterium Isolated from Soil.

A purple colony, designated as TRC1.1.SA was isolated from a tea garden soil sample.