Nanoscale Mapping of Magnetic Auto-Oscillations with a Single Spin Sensor.

Spin Hall nano-oscillators convert DC to magnetic auto-oscillations in the microwave regime. Current research on these devices is dedicated to creating next-generation energy-efficient hardware for communication technologies. Despite intensive research on magnetic auto-oscillations within the past decade, the nanoscale mapping of those dynamics remained a challenge.

Application of bioinformatic tools in cell type classification for single-cell RNA-seq data.

The advancements in single-cell RNA sequencing (scRNAseq) technology have significantly transformed genomics research, enabling the handling of thousands of cells in each experiment. As of now, 32,068 research studies have been cataloged in the Pubmed database. The primary aim of scRNAseq investigations is to identify cell types, understand the antitumor immune response, and identify new and uncommon cell types.

Repurposing of DrugBank molecules as dual non-hydroxamate HDAC8 and HDAC2 inhibitors by pharmacophore modeling, molecular docking, and molecular dynamics studies.

HDAC8 and HDAC2 are recently reported to be overexpressed in cervical cancer. To date, studies related to the use of dual targeted HDAC inhibitor to treat cervical cancer are not well explored. Again, majority of the selective HDAC inhibitors discovered so far are hydroxamic acids, which have multiple adverse side-effects due to their strong zinc chelating ability.

Quantitative Estimation of Albedo and Tilt Angle Variation in Bifacial Perovskite Solar Cells.

Bifacial perovskite solar cells (Bi-PSCs) have attracted substantial attention within the photovoltaic (PV) community due to their potential for enhanced power generation, suitability for integration into building structures and applicability in multijunction PV systems. This study presents the fabrication of efficient Bi-PSCs and investigates their unique properties using various characterization techniques, including Lambertian reflection effects through tilt angle arrangements and bottom albedo illuminations. The control device achieved a maximum power conversion efficiency (PCE) of 17.

Twist-Controlled Ferroelectricity and Emergent Multiferroicity in WSe Bilayers.

Recently, researchers have been investigating artificial ferroelectricity, which arises when inversion symmetry is broken in certain R-stacked, i.e., zero-degree twisted, van der Waals (vdW) bilayers.

Cholesterol Based Organogelators in Environmental Remediation: Applications in Removal of Toxic Textile Dyes and Oil Spill Recovery.

Oil spills in the ocean and textile dyes have a catastrophic impact on the environment, economy, and ecosystem. Phase-selective organic gelator dye sorption and oil separation for oil adsorption should meet certain criteria such as facile synthesis, low cost, effective gelation, and recyclability. This study has discovered that an aliphatic chain synthetic amphiphile based on cholesterol can produce organogels in a variety of organic solvents.

Scalable, Flexible, Magnetic-Field-Guided rULGO Sponge-BN-Cobalt Oxide-Based Supercapacitors: Mechanistic Insights into Multiple Charge Transfer Pathways by the Distribution of Relaxation Times.

Scalable and flexible supercapacitors are in high demand from an application point of view. Through our exploration, we have attained promising performance of electrochemical energy storage under the influence of an external magnetic field for future energy-based applications. In this work, a commercial sponge is used as a template for ultra-large graphene oxide (rULGO) functionalization, followed by the incorporation of CoO:BN without the inclusion of binders or conductive additives.

Emergent Inhomogeneity and Nonlocality in a Graphene Field-Effect Transistor on a Near-Parallel Moiré Superlattice of Transition Metal Dichalcogenides.

At near-parallel orientation, twisted bilayers of transition metal dichalcogenides exhibit interlayer charge transfer-driven out-of-plane ferroelectricity. Here, we report detailed electrical transport in a dual-gated graphene field-effect transistor placed on a 2.1° twisted bilayer WSe.

High-Performance Broadband Self-Driven Photodetector Based on MoS/CsCuBr Heterojunction.

Few-layer transition metal dichalcogenides and perovskites are both promising materials in high-performance optoelectronic devices. Here, we developed a self-driven photodetector by creating a heterojunction between few-layer MoS and lead-free perovskite CsCuBr. The detector shows a unique property of very high sensitivity in a broad spectral range of 400 to 800 nm with response speed in a millisecond order.

Green synthesis of chitosan gum acacia based biodegradable polymeric nanoparticles to enhance curcumin's antioxidant property: an zebrafish () study.

Green-synthesis of biodegradable polymeric curcumin-nanoparticles using affordable biodegradable polymers to enhance curcumin's solubility and anti-oxidative potential. The curcumin-nanoparticle was prepared based on the ionic-interaction method without using any chemical surfactants, and the particle-size, zeta-potential, surface-morphology, entrapmentefficiency, and in-vitro drug release study were used to optimise the formulation. The antioxidant activity was investigated using H2DCFDA staining in the zebrafish (Danio rerio) model.

The Renin-Angiotensin-Aldosterone System Regulates Sarcoidosis Granulomatous Inflammation.

Sarcoidosis is a granulomatous disorder of unclear cause notable for abnormal elevation of blood and tissue ACE1 (angiotensin converting enzyme 1) levels and activity. ACE1 regulates the renin-angiotensin-aldosterone system (RAAS), the terminal product of which is aldosterone, which selectively engages mineralocorticoid receptors to promote inflammation. We sought to determine whether the RAAS promotes sarcoidosis granuloma formation and related inflammatory responses.

Interplay of lattice-spin-orbital coupling and Jahn-Teller effect in noncollinear spinel TiMn(FeCo)O: a neutron diffraction study.

Local magnetostructural changes and dynamical spin fluctuations in doubly diluted spinel TiMn(FeCo)Ohas been reported by means of neutron diffraction and magnetization studies. Two distinct sets of compositions (i)(Ti) = 0.20 and(Fe) = 0.

Sarcoid-like reactions to immune checkpoint inhibitors: Incidence, treatment course, and impact on cancer progression and survival.

Introduction: Sarcoid-like reactions (SLRs) to immune checkpoint inhibitors (ICIs) are a rare but increasingly recognized immune-related adverse event of which the clinical significance is unclear.

Methods: We conducted a retrospective cohort study at a tertiary academic center of consecutive patients who received at least one dose of ICI from 2013 to 2020. Patient characteristics, risk factors, and outcomes were compared between patients with and without SLR following ICI treatment.

Targeted inhibition of colorectal cancer proliferation: The dual-modulatory role of 2,4-DTBP on anti-apoptotic Bcl-2 and Survivin proteins.

The anti-apoptotic proteins, Bcl-2 and Survivin, are consistently overexpressed in numerous human malignancies, notably in colorectal cancer. 2,4-Di-tert-butylphenol (2,4-DTBP) is a naturally occurring phenolic compound known for its diverse biological activities, including anti-cancer properties. The mechanism behind 2,4-DTBP-induced inhibition of cell proliferation and apoptosis in human colorectal cancer cells, specifically regarding Bcl-2 and Survivin, remains to be elucidated.

Ultrathin Dielectric Triggered Charge Injection Dynamics for High-Performance Metal Organic Framework/MXene Supercapacitors.

A MOF-MXene-BN three-component heterostructure exhibits impressive pseudocapacitive behavior with fast charge injection facilitated by an ultrathin dielectric h-BN. To address the MOF's low electronic conductivity, a 2D NiCo-MOF is grown on MXene nanosheets, enhancing conductivity and providing abundant redox-active sites. BN (boron nitride) serves a dual purpose, preventing restacking and facilitating charge injection toward NiCo-MOF.

Band structure sensitive photoresponse in twisted bilayer graphene proximitized with WSe.

The ability to tune the twist angle between different layers of two-dimensional (2D) materials has enabled the creation of electronic flat bands artificially, leading to exotic quantum phases. When a twisted blilayer of graphene (tBLG) is placed at the van der Waals proximity to a semiconducting layer of transition metal dichalcogenide (TMDC), such as WSe, the emergent phases in the tBLG can fundamentally modify the functionality of such heterostructures. Here we have performed photoresponse measurements in few-layer-WSe/tBLG heterostructure, where the mis-orientation angle of the tBLG layer was chosen to lie close to the magic angle of 1.

Thalidomide-Induced Primary Amenorrhea in a Patient With HbE/Beta-Thalassemia.

An 18-year-old girl was evaluated for primary amenorrhea. She was diagnosed with hemoglobin E (HbE)/beta-thalassemia during childhood and needed blood transfusions every month to maintain adequate hemoglobin levels. She was started on thalidomide to reduce her transfusion requirements at 12 years of age and became transfusion independent after 6 months.

Reentrant canonical spin-glass dynamics and tunable field-induced transitions in (GeMn)CoOKagomé lattice.

We report on the reentrant canonical semi spin-glass characteristics and controllable field-induced transitions in distorted Kagomé symmetry of (GeMn)CoO. This-site spinel exhibits complicated, yet interesting magnetic behaviour in which the longitudinal ferrimagnetic (FiM) order sets in below the Néel temperature∼ 77 K due to uneven moments of divalent Co (↑ 5.33) and tetravalent Mn (↓ 3.

Spectrum of Adrenal Dysfunction in Hemoglobin E/Beta Thalassemia.

Background: Adrenal insufficiency (AI) in hemoglobin E (HbE)/beta thalassemia, including evaluation of mineralocorticoid axis, had not been studied.

Aims And Objectives: In this study, we attempted to evaluate the prevalence of AI in HbE/beta thalassemia and wanted to determine if the prevalence of AI varied according to severity of HbE/beta thalassemia and transfusion requirements.

Methods: In this observational, cross-sectional study, 104 patients with HbE/beta thalassemia were evaluated.

VMHdm/c neuronal circuits regulate skeletal muscle PGC1-α via the sympathoadrenal drive.

Objective: To adapt to metabolically challenging environments, the central nervous system (CNS) orchestrates metabolism of peripheral organs including skeletal muscle. The organ-communication between the CNS and skeletal muscle has been investigated, yet our understanding of the neuronal pathway from the CNS to skeletal muscle is still limited. Neurons in the dorsomedial and central parts of the ventromedial hypothalamic nucleus (VMHdm/c) expressing steroidogenic factor-1 (VMHdm/c neurons) are key for metabolic adaptations to exercise, including increased basal metabolic rate and skeletal muscle mass in mice.

Frequency-Dependent Squeezed Vacuum Source for the Advanced Virgo Gravitational-Wave Detector.

In this Letter, we present the design and performance of the frequency-dependent squeezed vacuum source that will be used for the broadband quantum noise reduction of the Advanced Virgo Plus gravitational-wave detector in the upcoming observation run. The frequency-dependent squeezed field is generated by a phase rotation of a frequency-independent squeezed state through a 285 m long, high-finesse, near-detuned optical resonator. With about 8.

Investigation of anti-proliferative and anti-angiogenic properties of Parkia javanica bark and fruit extracts in zebrafish.

The use of herbal products as traditional medicines has been a practice in India for centuries. Due to high ethnic diversity, the pool of herbal medicines is enormous, and they are often preferred over modern medicines in certain parts of the country. Cancer is one of the major non-communicable diseases affecting people worldwide.

Therapeutic Signature of Stem Cell Derivative Exosomes in Oral Cancer: A Scoping Review.

Oral cancer poses a serious health challenge to the nations worldwide. India, among all the nations reported, has the largest number of oral cancer cases, which accounts for one-third of the entire population of oral cancer globally. As oral cancer is well-known for delayed diagnosis until an advanced stage, poor outcomes, and a lack of specific biomarkers for the disease and high-budget therapeutic alternatives.