Nidogen 2 Overexpression Promotes Hepatosteatosis and Atherosclerosis.

Clinical and genetic studies strongly support a significant connection between nonalcoholic fatty liver disease (NAFLD) and atherosclerotic cardiovascular disease (ASCVD) and identify ASCVD as the primary cause of death in NAFLD patients. Understanding the molecular factors and mechanisms regulating these diseases is critical for developing novel therapies that target them simultaneously. Our preliminary immunoblotting experiments demonstrated elevated expression of nidogen 2 (NID2), a basement membrane glycoprotein, in human atherosclerotic vascular tissues and murine steatotic livers.

Clinical Response and Corresponding Blood Transcriptome Pathways Pre- And Post-Treatment Of Hereditary Angioedema Prodromes Compared To Active Swelling Attacks.

Rationale: Approximately 85% Hereditary angioedema (HAE) attacks are associated with prodromal symptoms. We investigated the clinical effect of treating HAE-C1 inhibitor (HAE-C1INH) Type 1 patients with Conestat Alfa® (recombinant human C1-INH) during their prodrome versus an active swelling episode and associated changes in blood transcriptomic genes and pathways pre- vs. post-treatment.

Smooth muscle cell-specific CD47 deletion suppresses atherosclerosis.

Background: Recent smooth muscle cell (SMC)-lineage tracing and single-cell RNA sequencing (scRNA-seq) experiments revealed a significant role of SMC-derived cells in atherosclerosis development. Further, thrombospondin-1 (TSP1), a matricellular protein, and activation of its receptor cluster of differentiation (CD) 47 have been linked with atherosclerosis. However, the role of vascular SMC TSP1-CD47 signaling in regulating VSMC phenotype and atherogenesis remains unknown.

Large cell neuroendocrine carcinoma of oral cavity: A rare case report with review of literature.

Neuroendocrine tumours (NETs) primarily affect the lungs and larynx. Primary neuroendocrine carcinomas (NECs) rarely occur in the oral cavity. The classification of these tumours is ambiguous; however, the literature acknowledges their aggressiveness.

Evaluation of efficacy of two bag-mask ventilation techniques by novice airway providers: Two-handed CE versus dominant-hand CE-non-dominant-hand thenar eminence techniques - A randomised controlled trial.

Background And Aims: The conventional CE clamp technique may not effectively provide bag-mask ventilation (BMV) in the hands of inexperienced providers. Hence, we compared the efficacy of two-handed CE versus a hybrid technique.

Methods: One hundred thirty-two American Society of Anesthesiologists (ASA) I-II adult patients were randomised into groups A and B.

Short-term responses of identified soil beneficial-bacteria to the insecticide fipronil: toxicological impacts.

Pesticides including insecticides are often applied to prevent distortion posed by plant insect pests. However, the application of these chemicals detrimentally affected the non-target organisms including soil biota. Fipronil (FIP), a broad-spectrum insecticide, is extensively used to control pests across the globe.

Management of aseptic nonunions of bicondylar tibial plateau fractures.

Purpose: Nonunion of bicondylar tibial plateau (BTP) fractures following open reduction internal fixation (ORIF) is rare but challenging. We report a case series of aseptic BTP nonunions, approaches to treatment, and long-term outcomes.

Methods: Retrospective case series of aseptic nonunion in operatively treated BTP fractures.

Advanced framework for multilevel detection of digital video forgeries.

The rapid expansion of digital media has sparked significant concerns regarding the swift dissemination and potential misuse of forged video content. Existing forgery detection technologies primarily focus on simple forgeries and are still evolving, resulting in a critical gap in the detection of multilevel forgeries, where one forgery is layered over another. This paper presents an innovative framework designed to address this challenge by extracting intricate features from forged frames using attention-augmented convolutional neural networks (AACNNs).

In silico study, synthesis and antimalarial evaluation of hybrid pyridine substituted pyrazole 1,3,5-triazine derivatives.

Unlabelled: Malaria is a significant global public health issue, particularly prevalent in Africa, Asia, and Latin America, necessitating urgent research into novel and efficient therapies. In the current research, we have designed pyridine substituted pyrazole 1,3,5-triazine derivatives as antimalarials. A library including 300 compounds, designated as (-), has been generated using a variety of aliphatic and aromatic amines.

Pesticide pollution: toxicity, sources and advanced remediation approaches.

The Food and Agricultural Organization of the United Nations (FAO) estimates that food production must rise by 70% to meet the demands of an additional 2.3 billion people by 2050. This forecast underscores the persistent reliance on pesticides, making it essential to assess their toxicity and develop effective remediation strategies.

Identification of two transcription factors that work coordinately to regulate early development in .

The protozoan parasite has a life cycle that switches between infective cysts and invasive trophozoites. Encystation, a crucial process in parasite biology, is controlled by different mechanisms including transcriptional control. We identified two nuclear proteins in , EIN_066100 and EIN_085620, that regulate parasite development by binding to a DNA motif (TCACTTTC) in the promoter regions of genes upregulated in the first 8 h of stage conversion.

Engaging communities in therapeutics clinical research during pandemics: Experiences and lessons from the ACTIV COVID-19 therapeutics research initiative.

This manuscript addresses a critical topic: navigating complexities of conducting clinical trials during a pandemic. Central to this discussion is engaging communities to ensure diverse participation. The manuscript elucidates deliberate strategies employed to recruit minority communities with poor social drivers of health for participation in COVID-19 trials.

A young female's battle with toxic epidermal necrolysis induced by NSAIDs: a case report.

Introduction: Stevens-Johnson Syndrome (SJS) is a rare but severe mucocutaneous reaction often triggered by medications or infections, characterized by extensive epidermal detachment and mucosal involvement. This condition poses a high risk of morbidity and mortality, requiring prompt recognition and treatment.

Case Presentation: An 18-year-old Asian female from eastern Nepal presented with nonitchy red spots, high fever, and significant discomfort following the administration of ibuprofen for minor sores.

Phyto-toxicological effect of fipronil to plant seedlings: Assessing germination attributes, root-tip morphology, oxidative stress, and cellular respiration indices.

Pesticides including insecticides are applied in agricultural practices to control insect pests. However, their excessive usage often poses a severe threat to the growth, physiology, and biochemistry of plants. Here, responses of chickpea and greengram seedlings exposed to three fipronil (FIP) concentrations i.

Correlation of T Regulatory Cells, Cytotoxic T-lymphocyte-associated Antigen 4, and Transforming Growth Factor-β1 with Treatment Response in Patients with Chronic Myeloid Leukemia Receiving Dasatinib Therapy.

Background: Tyrosine kinase inhibitors improve chronic myeloid leukemia (CML) outcomes. Dasatinib inhibits breakpoint cluster region-Abelson 1 proto-oncogene tyrosine kinase better than imatinib in CML. T-regulatory cells prevent autoimmune diseases and aberrant immune responses by reducing oncoprotein antigen reactivity.

Enhanced Plasma Stability and Potency of Aryl/Acyloxy Prodrugs of a BTN3A1 Ligand.

While ester-based phosphonate prodrugs excel at delivering payloads into cells, their instability in plasma is a hurdle for their advancement. Here, we synthesized new aryl/acyloxy prodrugs of a phosphonate BTN3A1 ligand. We evaluated their phosphoantigen potency by flow cytometry and ELISA and their plasma and cellular metabolism by LC-MS.