Publications by authors named "Singh N"

Background: Cerebral venous thrombosis (CVT) is a rare but severely disabling form of stroke. Acute treatment mainly consists of medical management, since there is no robust evidence suggesting the benefit of endovascular treatment for CVT. Given the relative lack of data to guide acute treatment decision-making, CVT treatment decisions are mostly made on a case-by-case basis.

View Article and Find Full Text PDF

Rationale: Alzheimer's disease (AD), an age-dependent devastating neuropsychiatric disorder, is a leading cause of learning, memory and intellectual disabilities. Current therapeutic approaches for the amelioration of the anomalies of AD are not effective.

Objective: In the present study, the molecular mechanisms underlying sporadic AD (sAD), the memory related behavioral analysis and neuroprotective effects of Ellagic acid (EA) were investigated.

View Article and Find Full Text PDF

This study examines the effectiveness of lupeol and metformin in a mouse model of dementia generated by intracerebroventricular streptozotocin (i.c.v.

View Article and Find Full Text PDF
Article Synopsis
  • * Conducted as a single-blind randomized controlled trial, participants engaged in daily 30-minute yoga sessions online and were assessed using questionnaires and Breath-o-meter measurements over 90 days.
  • * Results indicated that those practicing yoga experienced significant improvements in both peak expiratory flow rate and asthma-related quality of life compared to the control group, confirming yoga's positive impact on managing asthma symptoms.
View Article and Find Full Text PDF

Background And Purpose: The safety and efficacy of tenecteplase in patients with ischemic stroke due to medium vessel occlusion (MeVO) are not well studied. We aimed to compare tenecteplase with alteplase in stroke due to MeVO.

Methods: Patients with baseline M2-middle cerebral artery (MCA), M3/M4-MCA, P2/P3/P4-posterior cerebral artery (PCA), A2/A3/A4-anterior cerebral artery (ACA) occlusions from the Alteplase Compared to Tenecteplase (AcT) trial were included.

View Article and Find Full Text PDF

Antibodies to high-frequency antigens are rarely implicated in cases of hemolytic disease of the fetus and newborn (HDFN), yet they pose a challenge to both clinical staff and transfusion medicine, especially with the identification of the implicating antibody and the arrangement of compatible blood for intrauterine transfusion. Here we report one such interesting case of HDFN caused by an alloantibody to a high-frequency antigen belonging to the Rhesus (Rh) blood group system. The patient presented at the 19th week with Rh-isoimmunized pregnancy.

View Article and Find Full Text PDF

Acute myeloid leukemia (AML) is fatal in the majority of adults. Identification of new therapeutic targets and their pharmacologic modulators are needed to improve outcomes. Previous studies had shown that immunization of rabbits with normal peripheral WBCs that had been incubated with fluorodinitrobenzene elicited high titer antibodies that bound to a spectrum of human leukemias.

View Article and Find Full Text PDF
Article Synopsis
  • Prolonged wound healing is a major clinical issue, and this research explores nanotechnology, specifically nanofiber (NF) scaffolds, as a potential solution.
  • The study developed multifunctional AZL-CS/PVA-NF scaffolds enriched with azilsartan medoxomil, showing a drug release rate of around 93.86% and good antimicrobial properties against common bacteria like Staphylococcus aureus.
  • In vivo results indicated that these scaffolds enhance tissue regeneration and reduce inflammation in a rat model, highlighting their promise as innovative drug carriers for improving wound care.
View Article and Find Full Text PDF

Background: Growth-regulating factors (GRFs) are crucial in rice for controlling plant growth and development. Among the rice cultivation practices, aerobic methods are water efficient but result in significant yield reduction relative to non-aerobic cultivation. Therefore, mechanistic insights into aerobic rice cultivation are important for improving the aerobic performance of rice.

View Article and Find Full Text PDF

Cardiovascular diseases (CVDs) are the leading cause of death globally. Their prevalence and mortality rates continue to rise. This narrative review explores well-known risk factors for CVDs such as dyslipidemia, hypertension, diabetes, obesity, and smoking, and their prevalence among different racial and ethnic groups.

View Article and Find Full Text PDF

Nature uses complex self-assembly pathways to access distinct functional non-equilibrium self-assemblies. This remarkable ability to steer same set of biomolecules into different self-assembly states is done by avoiding thermodynamic pit. In synthetic systems, on demand control over 'Pathway Complexity' to access self-assemblies different from equilibrium structures remains challenging.

View Article and Find Full Text PDF
Article Synopsis
  • Scientists studied 144 types of pigeonpea plants to understand how genes affect when they flower and how tall they grow.
  • They found 29 important gene markers that are linked to flowering time and plant height, with some genes affecting both traits at the same time.
  • Eight different "haplotypes" were discovered, which help predict if a plant will flower early or late, and some of these haplotypes are also connected to the height of the plants.
View Article and Find Full Text PDF

Background: Previous cross-sectional studies have found a beneficial relationship between greenspace and children's behaviour. Nevertheless, evidence on the mechanisms underlying this association remains scant. We examined whether the availability of greenspace was related to fewer behavioural problems in Polish children and investigated potential mechanisms.

View Article and Find Full Text PDF

Artifacts in nuclear medicine imaging are not uncommon. We are aware of some of these, for which we follow necessary protocols to avoid them. However, there are some unusual and unavoidable artifacts that we come across in daily imaging, which may be of concern and need to be detected and corrected on time.

View Article and Find Full Text PDF

This work successfully demonstrates a sustainable and environmentally friendly approach for synthesizing Semal-ZnO nanoparticles (NPs) using the aqueous leaf extract of L. These NPs exhibit an absorption peak at approximately 390 nm in the UV-visible spectrum and an energy gap (E) of 3.11 eV.

View Article and Find Full Text PDF

Oral bioavailability of glibenclamide (Glb) was appreciably improved by the formation of an amorphous solid dispersion with Poloxamer-188 (P-188). Poloxamer-188 substantially enhanced the solubility and thereby the dissolution rate of the biopharmaceutics classification system (BCS) class II drug Glb and simultaneously exhibited a better stabilizing effect of the amorphous solid dispersion prepared by the solvent evaporation method. The physical state of the dispersed Glb in the polymeric matrix was characterized by differential scanning calorimetry, X-ray diffraction, scanning electron microscope and Fourier transform infrared studies.

View Article and Find Full Text PDF

Background and objective Down syndrome (DS) is characterized by the presence of an additional chromosome; it is a typical chromosomal disorder causing intellectual disability in individuals. The diagnostic process for DS often involves conventional karyotyping, which can be time-consuming. Trisomy 21 and other chromosomal abnormalities may now be quickly and accurately diagnosed using quantitative fluorescence polymerase chain reaction (QF-PCR).

View Article and Find Full Text PDF

Objectives: Evidence-based prescribing is essential to optimize patient outcomes in cystitis. This requires knowledge of local antibiotic resistance rates. Diagnostic and Antimicrobial Stewardship (DASH) to Protect Antibiotics (https://dashuti.

View Article and Find Full Text PDF

This work aimed to manufacture Ti-28.5Nb and Ti-40.0Nb (wt%) alloys selective laser melting (SLM) from Ti and Nb elemental powders.

View Article and Find Full Text PDF

Background: Nanophytosomes represent an effective choice for topical drug delivery systems thanks to their small size, general non-toxicity, ease of functionalization and high surface to volume ratio. The goal of the current study was to investigate the potential benefits of using extract nanogel as a means of improving skin penetration and prolonging skin deposition in dermatitis similar to psoriasis.

Methods: Nanophytosomes (NPs) were developed, optimised and thoroughly characterised.

View Article and Find Full Text PDF

Members of the family Trichomeriaceae, belonging to the Chaetothyriales order and the Ascomycota phylum, are known for their capability to inhabit hostile environments characterized by extreme temperatures, oligotrophic conditions, drought, or presence of toxic compounds. The genus Knufia encompasses many polyextremophilic species. In this report, the genomic and morphological features of the strain FJI-L2-BK-P2 presented, which was isolated from the Mars 2020 mission spacecraft assembly facility located at the Jet Propulsion Laboratory in Pasadena, California.

View Article and Find Full Text PDF

The planar cell polarity (PCP) system is essential for positioning cells in 3D networks to establish the proper morphogenesis, structure, and function of organs during embryonic development. The PCP system uses inter- and intracellular feedback interactions between components of the core PCP, characterized by coordinated planar polarization and asymmetric distribution of cell populations inside the cells. PCP signaling connects the anterior-posterior to left-right embryonic plane polarity through the polarization of cilia in the Kupffer's vesicle/node in vertebrates.

View Article and Find Full Text PDF

Purpose: To report distinctive clinical and imaging features of iris freckles to differentiate them from iris nevi.

Design: Retrospective observational study.

Subjects: 53 patients (277 freckles) with incidental iris freckles and 102 patients (104 nevi) with iris nevi that are either clinically stable or pathologically confirmed.

View Article and Find Full Text PDF