Publications by authors named "Singam V"
Article Synopsis
- Lipofibromatosis-like neural tumors (LPF-NTs) are a new type of spindle cell tumors, characterized by a unique pattern and specific markers like CD34 and S100, as well as genetic changes involving the NTRK1 gene.
- A case study is presented involving an 11-year-old patient with LPF-NT showing a distinct honeycomb pattern similar to dermatofibrosarcoma protuberans, along with specific co-expressions and gene rearrangements.
- The paper also reviews 73 previously documented cases of LPF-NT to highlight the evolving understanding of this tumor type.
Background: Patient-Reported Outcomes Measurement Information System Global Health (PGH) was validated to assess health-related quality of life in several diseases. Little is known about its measurement properties in adult atopic dermatitis.
Objective: Examine the measurement properties of PGH in adult atopic dermatitis.
Background: Few outcome measures were validated for assessing depressive symptoms in AD. Patient Health Questionnaire-9 (PHQ9) and the abridged PHQ2 are established patient-reported outcome measures of depressive symptoms.
Objective: We sought to examine the measurement properties of PHQ9 and PHQ2 in adult AD.
Background: Multiple strategies have been used to evaluate the minimal important change (MIC) of the Eczema Area and Severity Index (EASI) and Scoring Atopic Dermatitis (SCORAD). The meaningfulness of these MICs is not well established across all severities of atopic dermatitis (AD).
Objectives: To determine the MIC of percentage and absolute improvement of EASI and SCORAD scores in adults and children with AD.
Background: The ideal patient-reported outcome measure to assess sleep disturbance in atopic dermatitis (AD) has not been determined.
Objective: We sought to determine the measurement properties of the Patient-Reported Outcomes Measurement Information System (PROMIS) Itch Questionnaire Mood and Sleep (PIQ-MS), Sleep Disturbance (SD), Sleep-Related Impairment (SRI), and Epworth Sleepiness Scale (ESS) in adults with AD.
Methods: A prospective dermatology practice-based study was performed using questionnaires and evaluation by a dermatologist (n=611).
Background: Multiple clinician-reported outcome measures exist for atopic dermatitis (AD) severity. However, there is no gold standard for use in clinical practice.
Objectives: To determine the measurement properties of the product of validated Investigator's Global Assessment for AD (vIGA) and body surface area (BSA) overall or divided into six categories (cBSA: 0%/0.
Association of itch triggers with atopic dermatitis severity and course in adults.
Ann Allergy Asthma Immunol
November 2020
Background: Atopic dermatitis (AD) is associated with heterogeneous triggers of itch, which may affect AD course and severity.
Objective: To characterize the triggers of itch in adult AD.
Methods: This was a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist (n = 587).
Background: Atopic dermatitis (AD) is associated with itch, pain, and sleep disturbance, all of which may contribute toward cognitive dysfunction.
Objective: To determine the relationship of AD severity and cognitive function in adults.
Methods: We performed a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist (n = 386).
Background: Multiple atopic dermatitis (AD) severity scales exist, with no gold standard for use in clinical practice.
Objectives: To determine the measurement properties of the Rajka-Langeland score and compare it with other clinician-reported outcomes in adults and children with AD.
Methods: We performed a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist (n = 427).
Background: Little is known about the measurement properties of Patient-Oriented Scoring Atopic Dermatitis (PO-SCORAD) in adults with atopic dermatitis (AD). Even less is known about how PO-SCORAD performs compared with the Patient-Oriented Eczema Measure (POEM).
Objective: To examine the measurement properties of PO-SCORAD and compare them with those of POEM.
Article Synopsis
- Asthma is commonly found in patients with atopic dermatitis (AD), prompting a systematic review and meta-analysis to explore this relationship and asthma's prevalence in these patients.
- The analysis reviewed 213 studies, revealing that 25.7% of individuals with AD also have asthma, compared to 8.1% in the general population, indicating a significant association between the two conditions.
- The study highlights variations in how asthma and AD were defined across research, and recommends that physicians should pay attention to potential asthma symptoms in patients with AD.
Background: Little is known about the validity of numeric rating scales (NRS) and verbal rating scales (VRS) for itch and itch frequency for assessing itch severity in atopic dermatitis (AD). We evaluated the Patient-Reported Outcomes Information System (PROMIS ) Itch Questionnaire (PIQ) - itch severity assessment, including multiple NRS, VRS and frequency of itch assessments, in adults with AD and compared their performance.
Methods: Self-administered questionnaires and skin examinations were performed in 410 patients with AD (aged 18-90 years) in a dermatology practice setting.
Prurigo nodularis (PN) and lichen simplex chronicus (LSC) are debilitating chronic pruritic diseases that can lead to and be exacerbated by psychosocial distress. However, little is known about the mental health (MH) comorbidities of PN/LSC. We sought to evaluate the likelihood and cost-burden of MH comorbidities and emergencies associated with PN/LSC.
View Article and Find Full Text PDFBackground: Sleep disturbances are common in adults with atopic dermatitis (AD). Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep Disturbance (SD) and Sleep-Related Impairment (SRI) are validated questionnaires to assess sleep in adults. Little is known about their measurement properties in adults with AD.
View Article and Find Full Text PDFBackground: It is known that malignant melanoma (MM) survivors are at increased risk of future primary MM. However, the risk for noncutaneous second primary malignancies (SPMs) is not as well-understood.
Methods: An observational study utilizing data from the Surveillance, Epidemiology, and End Results (SEER) database was performed, assessing data from patients diagnosed with primary cutaneous MM to measure overall, as well as specific, tumor type and risk of SPM.
Background: The optimal approaches for monitoring sleep disturbances in adults with atopic dermatitis (AD) is not established. Multiple patient-reported outcome measures for AD and itch have sleep-related items. These items have not been validated previously.
View Article and Find Full Text PDFBackground: The Patient-Reported Outcomes Measurement Information System (PROMIS) Itch Questionnaire (PIQ) was recently developed.
Objective: To validate PIQ short forms in adults with AD.
Methods: Self-administered questionnaires and skin examinations were performed in 239 adults with atopic dermatitis (AD) in a dermatology practice setting.
Background: Atopic dermatitis (AD) has a variable disease course and intermittent triggers, and responses to topical therapy vary, potentially affecting the magnitude of the placebo response in AD trials.
Objective: To determine the predictors of increased placebo response in randomized controlled trials of AD.
Methods: We performed a systematic review and meta-analysis of randomized controlled trials for systemic therapy in AD published during 2007-2018.
Background: Psoriasis is associated with psychosocial distress. Little is known about the relationship between psoriasis and mental health (MH) emergencies.
Objective: To examine the associations of psoriasis and MH hospitalizations in the USA.
Background: Hidradenitis suppurativa (HS) is associated with bacterial colonization, skin-barrier disruption, immune dysregulation and treatments that can increase infection risk.
Objectives: To determine whether HS is associated with cutaneous and extracutaneous infections and related outcomes.
Methods: Data from the 2002-2012 National Inpatient Sample were analysed, including a 20% sample of U.
Background: Little is known about the mental health (MH) hospitalization among patients with acne and rosacea.
Aims: To determine the MH disorders and cost burden associated with acne and rosacea.
Methods: Data were examined from the 2002-2012 US National Inpatient Sample, comprising a sample of ~20% of all US paediatric and adult hospitalizations (n = 87 053 155 admissions).
Background: Allergic contact dermatitis to metals is a significant clinical and public health problem. Little is known about the determinants of polysensitization to metals.
Objective: The aim of the study was to determine the frequency and predictors of nickel co-reactions and metal polysensitization.