Multi-Harmonic Nonlinear Ultrasonic Fusion with Deep Learning for Subtle Parameter Identification of Micro-Crack Groups.

Fatigue crack defects in metallic materials significantly reduce the remaining useful life (RUL) of parts. However, much of the existing research has focused on identifying single-millimeter-scale cracks using individual nonlinear ultrasonic responses. The identification of subtle parameters from complex ultrasonic responses of micro-crack groups remains a significant challenge in the field of nondestructive testing.

Enhanced Human Activity Recognition Using Wi-Fi Sensing: Leveraging Phase and Amplitude with Attention Mechanisms.

Wi-Fi-based human activity recognition (HAR) is a non-intrusive and privacy-preserving method that leverages Channel State Information (CSI) for identifying human activities. However, existing approaches often struggle with robust feature extraction, especially in dynamic and multi-environment scenarios, and fail to effectively integrate amplitude and phase features of CSI. This study proposes a novel model, the Phase-Amplitude Channel State Information Network (PA-CSI), to address these challenges.

An Investigation on the Ball Screw-Based Variable Displacement Mechanism for Axial Piston Pumps with Feedforward Differential Input Control.

This paper proposes a variable mechanism structure based on a ball screw design for precise displacement control in axial piston pumps, with the objective of improving actuator position and velocity control within the displacement-controlled (DC) systems. Traditional valve-controlled cylinder variable mechanisms (VCCVM) often suffer from limited control precision over the swash plate due to numerous uncertain parameters within the hydraulic system. To address this issue, a ball screw is utilized to replace the original valve-controlled cylinder for swash plate control, enhancing accuracy and responsiveness.

Dynamic Obstacle Avoidance with Enhanced Social Force Model and DWA Algorithm Using SparkLink.

In the context of Industry 4.0, addressing the challenge of dynamic obstacle avoidance for Automated Guided Vehicles (AGVs) in complex industrial environments, this paper proposes an algorithm that integrates an enhanced social force model (SFM) and an improved dynamic window approach (DWA), leveraging SparkLink communication technology to enhance data transmission speed and reliability. The introduction of SparkLink technology significantly improves the environmental perception capabilities of AGVs, optimizing their dynamic obstacle-avoidance performance.

Fatigue Damage Evolution Mechanism of Asphalt Binder Under Variable Stress Repeated Loading.

Continuous loading on asphalt pavements induces fatigue damage at the interface between the asphalt binder and aggregate or within the binder itself. The understanding of asphalt's fatigue response is considered crucial for the prolongation of pavement service life. Variable stress fatigue tests were conducted on asphalt binders, with conditions such as stress amplitude being altered to analyze fatigue performance and life.

Design and Optimization of the Injection Mold for Rubber Stators in Oil Production Single-Screw Pumps.

This study aimed to optimize the injection mold for oil production single-screw pump rubber stators. MOLDFLOW2023 analysis post-design determined the optimal gate position and gating system, and it also analyzed the impact of key parameters on quality. The optimization led to a significant improvement in product quality.

Optimization of Bio-Based Polyurethane Elastic Nanofibrous Membrane via Electrospinning for Waterproof and Breathable Applications.

Bio-based polyurethane (BPU) offers excellent biocompatibility and outstanding elasticity, providing vast potential for the development of next-generation waterproof and breathable materials. However, achieving stable and uniform electrospinning of BPU remains a significant challenge. Herein, BPU with superior electrospinning performance was synthesized using poly(butylene sebacate), poly(trimethylene ether glycol), ethylene glycol, and methylene diphenyl diisocyanate (MDI) as raw materials.

High-Efficiency Surface-Cooled Rapid Tooling Development for Injection Molding of Low-Density Polyethylene.

Epoxy resin filled with aluminum particles constitutes a polymer composite material commonly utilized in research and development departments to fabricate rapid tooling for prototyping new designs. This study developed aluminum-filled epoxy resin molds by incorporating surface-cooled cooling channels (SCCCs) to enhance cooling performance, validated through Moldex3D simulation and experimental analysis. The simulation revealed that a 1 mm mesh size was utilized to balance accuracy and efficiency, with simulations revealing the complete filling of the injection-molded product within 5 s.

Antitumor Activity of USP7 Inhibitor GNE-6776 in Non-Small Cell Lung Cancer Involves Regulation of Epithelial-Mesenchymal Transition, Cell Cycle, Wnt/β-Catenin, and PI3K/AKT/mTOR Pathways.

Non-small cell lung cancer (NSCLC) is a major cause of cancer-related deaths worldwide. This study investigated the effects and mechanisms of the USP7 inhibitor GNE-6776 on human NSCLC A549 and H1299 cells, providing insights for anti-NSCLC drug development. USP7 expression was analyzed in lung cancer tissue using data from public databases.

Synthesis and Evaluation of Ga- and Lu-Labeled [diF-Pro]Bombesin(6-14) Analogs for Detection and Radioligand Therapy of Gastrin-Releasing Peptide Receptor-Expressing Cancer.

Overexpressed in various solid tumors, the gastrin-releasing peptide receptor (GRPR) is a promising target for cancer diagnosis and therapy. However, the high pancreas uptake of the current clinically evaluated GRPR-targeted radiopharmaceuticals limits their applications. In this study, we replaced the Pro residue in our previously reported GRPR-targeted LW02056 and ProBOMB5 with 4,4-difluoroproline (diF-Pro) to obtain an agonist LW02060 (DOTA-Pip-[D-Phe,Tle,NMe-His,diF-Pro]Bombesin(6-14)) and an antagonist LW02080 (DOTA-Pip-[D-Phe,NMe-Gly,Leu(ψ)diF-Pro]Bombesin(6-14)), respectively.

Mesenchymal Stem Cells with Simultaneous Overexpression of GPX3 and CD47 for the Treatment of Drug-Induced Acute Liver Injury.

The liver, as the largest metabolic and detoxification organ in mammals, metabolizes approximately 80-90% of drugs. However, drug-induced liver injury (DILI) is common and driven by factors such as individual variability, differences in liver metabolism, and improper drug use. Mesenchymal stem cells (MSCs), with their self-renewal and multipotent differentiation capabilities, offer therapeutic potential, but face challenges such as limited proliferation and increased apoptosis during in vitro expansion.

Therapeutic Assessment of Diverse Doxycycline-Based Formulations in Promoting Deep Corneal Wound Healing: Evidence from a Rat Model.

Doxycycline (Dxy), a broad-spectrum antibiotic with anti-inflammatory effects, is commonly used in ophthalmology but is unstable as a topical eyedrop, degrading quickly into inactive forms and requiring frequent application. To address this, gelatin nanoparticles (GNPs) loaded with Dxy (DNPs) were developed as a stable ophthalmic nanomedicine for enhancing corneal wound healing by inhibiting matrix metalloproteinases (MMPs). In this study, female Sprague-Dawley rats underwent lamellar keratectomy, and various Dxy formulations-oral, conventional eyedrops, and DNP-containing eyedrops-were evaluated for corneal wound repair.

Screening, Identification, and Fermentation Optimization of the Antagonistic Actinomycete Strain TCS21-117 Against .

Biological control is considered one of the most important methods for preventing and controlling the worldwide fungal disease gray mold, caused by . Among the various agents used in biological control, actinomycetes represent a significant group of microorganisms that offer valuable resources for biocontrol strategies. In this study, a total of 132 actinomycetes, belonging to four genera (, , , and ), were isolated from soil.

Antibiotic Resistance Profiles and Genomic Analysis of Endophytic Bacteria Isolates from Wild Edible Fungi in Yunnan.

The use of antibiotics has led to the emergence of antibiotic resistance, posing significant challenges in the prevention, control, and treatment of microbial diseases, while threatening public health, the environment, and food safety. In this study, the antibiotic resistance phenotypes and genotypes of 56 endophytic bacteria isolates from three species of wild edible fungi in Yunnan were analyzed using the Kirby-Bauer disk diffusion method and PCR amplification. The results revealed that all isolates were sensitive to ofloxacin, but resistance was observed against 17 other antibiotics.

Impact of Feed Composition on Rumen Microbial Dynamics and Phenotypic Traits in Beef Cattle.

The rumen microbiome is central to feed digestion and host performance, making it an important target for improving ruminant productivity and sustainability. This study investigated how feed composition influences rumen microbial abundance and phenotypic traits in beef cattle. Fifty-nine Angus bulls were assigned to forage- and grain-based diets in a randomized block design, evaluating microbial dynamics, methane emissions, and feed efficiency.

RNA Helicase DDX3 Interacts with the Capsid Protein of Hepatitis E Virus and Plays a Vital Role in the Viral Replication.

DDX3 is an ATP-dependent RNA helicase that is involved in multiple cellular activities, including RNA metabolism and innate immunity. DDX3 is known to assist the replication of some viruses while restricting others through its direct interaction with viral proteins. However, the role of DDX3 in the replication of the hepatitis E virus (HEV) is unknown.

Merkel Cell Polyomavirus Co-Infection in HIV/AIDS Individuals: Clinical Diagnosis, Consequences and Treatments.

Merkel cell polyomavirus (MCV) was named for its role as the causative agent of Merkel cell carcinoma (MCC), which is MCV positive in approximately 80% of cases. MCV is classified as a Group 2A carcinogen, which promotes carcinogenesis by integrating T-antigen into the cell genome. The prevalence of anti-MCV antibodies in the general population can be as high as 90%.

Challenges in Diagnosis and Management of Atlantoaxial Tuberculosis: A Case Report.

: Atlantoaxial tuberculosis (TB) is rare, and its diagnosis is difficult. Herein, we present a rare case with a challenging diagnostic journey of atlantoaxial TB spanning over two years. : A 70-year-old immunocompetent female patient presented with a four-week history of nuchal pain, stiffness, and headache.

Comparing Different Montages of Transcranial Direct Current Stimulation in Treating Treatment-Resistant Obsessive Compulsive Disorder: A Randomized, Single-Blind Clinical Trial.

: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation for treatment-resistant obsessive compulsive disorder (OCD). We aim to compare the treatment outcomes of a newly developed dual-site cathodal tDCS method over the orbitofrontal cortex (OFC) and pre-supplementary motor area (pre-SMA) and two previously reported montages (cerebellum-OFC and pre-SMA) in patients with treatment-resistant OCD. : Eighteen OCD patients were randomly assigned to receive twice-daily 2 mA/20 min sessions for 10 consecutive weekdays, with the active cathode placed on the cerebellum-OFC, bilateral pre-SMA, or OFC-pre-SMA tDCS.

Microwave-Assisted Doping Engineering Construction of Spinel-Structured Nonstoichiometric Manganese Cobaltite with Mixed 1D/2D Morphology for Supercapacitor Application.

High-performance electrode materials are fundamental to improving supercapacitor performance, serving as key factors in developing devices with high energy density, high power density, and excellent cyclic stability. Non-stoichiometric spinels with phase deficiencies can achieve electrochemical performance that surpasses that of stoichiometric materials, owing to their unique structural characteristics. In this study, we used a microwave-assisted method to synthesize a high-performance non-stoichiometric spinel material with phase deficiencies, MnCoO, which displayed a wide potential window (1.

Structure-Based Virtual Screening of Potential Inhibitors Targeting the Prolyl-tRNA Synthetase (PRS) in : Insights from Molecular Docking, ADMET Studies, and Molecular Dynamics Simulations.

Avian coccidiosis, caused by protozoan parasites of the genus , poses a major threat to the poultry industry worldwide, leading to severe economic losses through reduced growth rates, poor feed efficiency, and increased mortality. Although the conventional management of this disease has relied on anticoccidial drugs, the overwhelming use of these agents has led to the rapid emergence and spread of drug-resistant isolates, highlighting the urgent need for novel therapeutic approaches. This study employed computational approaches to identify novel inhibitors targeting prolyl-tRNA synthetase (EtPRS).

One-Step Fabrication of Poly(vinylidene Fluoride-Co-Hexafluoropropylene)/Perfluorodecyltriethoxysilane Fibrous Membranes with Waterproof, Breathable, and Radiative Cooling Properties.

Functional membranes with waterproof, breathable, and thermal regulation capabilities are increasingly sought after across various industries. However, developing such functional membranes commonly involves complex multi-step preparation processes. Herein, we introduced perfluorodecyltriethoxysilane (FAS) into the poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) solution for one-step electrospinning, successfully fabricating membranes that combine these properties.

Oxidative Balance Score Calculated Using Different Methods and Its Associations with Colorectal Cancer Risk.

Background: The oxidative balance score (OBS) measures oxidative stress from diet and lifestyle, but research linking it to colorectal cancer (CRC) risk is scarce and varies in calculation methods.

Methods: We conducted a case-control study in Guangzhou, China, involving 2799 CRC cases and an equal number of sex- and age-matched controls. We adopted and compared four different methods for calculating the OBSs.

Association Between Triglyceride-Glucose Related Index and Endometriosis Varies According to Educational Level.

Background: The association between the triglyceride-glucose (TyG) level, its obesity-related derivatives, and the occurrence of endometriosis (EMS) remains ambiguous, particularly in individuals with higher levels of education. This study sought to explore the relationship between TyG, its obesity-related derivatives, and EMS across various educational backgrounds.

Methods: This study utilized a substantial dataset obtained from four cycles of the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2006.

Integrative Roles of Functional Foods, Microbiotics, Nutrigenetics, and Nutrigenomics in Managing Type 2 Diabetes and Obesity.

Diabetes and obesity are globally prevalent metabolic disorders posing significant public health challenges. The effective management of these conditions requires integrated and personalized strategies. This study conducted a systematic literature review, identifying 335 relevant papers, with 129 core articles selected after screening for duplicates and irrelevant studies.