[Comparison of the accuracy between magnetic resonance hydrography and CT myelography in diagnosing of spontaneous intracranial hypotension syndrome].

To compare the accuracy of spinal magnetic resonance myelography (MRM) and CT myelography (CTM) in the detection of spontaneous intracranial hypotension (SIH). The clinica data of SIH patients at the Neurology Department of Zhongshan Hospital Affiliated to Fudan University between June 2021 and August 2023 were prospectively collected. MRM was performed first, CTM, followed by CTM.

CaGA nanozymes inhibit oxidative stress and protect mitochondrial function in ulcerative colitis therapy.

Ulcerative colitis (UC) is a long-term inflammatory bowel disease characterized by intense inflammation of the colorectal mucosa. Overproduction of reactive oxygen species exacerbates the progression of UC, which is linked to mitochondrial impairment and dysbiosis of the intestinal microbiota. CaGA nanozymes have demonstrated efficacy in the treatment of UC.

Synergistic impact of 25-hydroxyvitamin D and physical activity on incident depression: Evidence from prospective cohorts and genome-wide data.

Background: The relationship between 25-hydroxyvitamin D [25(OH)D] levels, physical activity (PA), and depression risk remains underexplored. This study examines how combinations of 25(OH)D and PA influence depression.

Methods: We conducted a longitudinal analysis using data from the English Longitudinal Study of Ageing, including cognitively healthy adults aged 50 years and older at baseline.

Alleviative effects of phosphates on quality deterioration of frozen dough during freeze-thaw cycles: A focus on gluten aggregation and dough fermentation.

This study investigated the effects of phosphates on the quality of frozen steamed bread, focusing on rheological properties, water status, fermentation characteristics, and protein aggregation properties. The findings revealed that phosphates significantly improved the quality of frozen steamed bread. After 3 freeze-thaw (F/T), the specific volumes of 0.

Cardiovascular Outcomes of Patients With Type 2 Diabetes With Urinary Tract Infection Post Sodium-Glucose Cotransporter 2 Inhibitors Treatment: A Multicenter Observational Study.

Objectives: Urinary tract infection (UTI) is an adverse effect of sodium-glucose cotransporter 2 inhibitors (SGLT2i). However, its effect on cardiovascular outcomes in type 2 diabetes mellitus (T2DM) patients remains unclear.

Methods: This multicenter retrospective observational study included diabetes patients who received SGLT2 inhibitors (SGLT2i) between January 2016 and January 2019.

Efficacy Study of Lymphaticovenular Anastomosis via the Lymphosome-based Four-incision Approach for Lower Limb Lymphedema.

Background: Lower limb lymphedema (LLL) is a chronic condition with impaired lymphatic drainage. Lymphaticovenular anastomosis (LVA) is a promising microsurgical treatment for LLL. Refined surgical techniques, such as optimal incision placement and precise lymphatic vessel identification, are essential for better clinical outcomes.

2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucopyranoside promotes skin flap survival by promoting mitophagy through the PINK1/Parkin pathway.

Ethnopharmacological Relevance: 2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucopyranoside (THSG), the active compound in Polygonum multiflorum (PM), exhibits potential therapeutic effects, including combating oxidative stress, possessing anti-tumor properties, and protecting against ischemia-reperfusion injury. However, the influence and mechanisms by which THSG affects skin flap survival remain unclear.

Aim Of Study: To investigate the effects and underlying mechanisms of THSG to promote the survival rate of skin flap.

Qingre Huayu Jianpi prescription alleviates the inflammatory transformation of colitis-associated colorectal cancer by inhibiting the IL-17RA/ACT1/NF-κB axis.

Ethnopharmacological Relevance: Inflammation-to-cancer transformation is critical for the progression of ulcerative colitis to colitis-associated colorectal cancer (CAC).

Aim Of The Study: To explore the role and potential mechanisms of Qingre Huayu Jianpi prescription (QHJ) treatment in the development of CAC.

Materials And Methods: Combined network pharmacology and transcriptome analyses were used to investigate QHJ-associated targets and pathways in the context of CAC.

An artificial intelligence tool that may assist with interpretation of rapid plasma reagin test for syphilis: development and on-site evaluation.

Objectives: The rapid plasma reagin (RPR) test, a traditional method for diagnosing syphilis and evaluating treatment efficacy, relies on subjective interpretation and requires high technical proficiency. This study aimed to develop and validate a user-friendly RPR-artificial intelligence (AI) interpretative tool.

Methods: A dataset comprising 600 images of photographed RPR cards from 276 negative and 223 positive RPR samples was used for model development.

Glutamatergic projections from the basolateral amygdala to medial prefrontal cortex contribute to acute itch sensation processing.

Itch refers to an aversive sensation that generates a desire to scratch. The basolateral amygdala (BLA) activity is crucial in driving motivation, sensation, and emotional responses. Excitatory projections from the BLA play a vital role in turning neuronal activity throughout the brain, including the medial prefrontal cortex (mPFC).

Famsin and fasting adaptation: A glucagon connection.

Starvation triggers an organismal adaptive response that is orchestrated by endocrine factors. In this issue of Cell Metabolism, Long et al. uncover a famsin-glucagon axis that relays gut-derived hormonal cues to systemic glucose homeostasis during fasting.

Effects of dietary Bacillus velezensis fermented soybean hull supplementation on antioxidant capacity, suppressing pro-inflammatory, and modulating microbiota composition in broilers.

This study aimed to ferment soybean hulls (SBH) with Bacillus velezensis and evaluate their effects on broiler diets, specifically focusing on intestinal antioxidant capacity, immune modulation, and microbiota composition. The animal trial involved 400 one-day-old Arbor Acres broilers, randomly assigned to a control group (basic diet, Control) and groups receiving 5 % and 10 % unfermented soybean hulls (5 % USBH, 10 % USBH) and 5 % and 10 % fermented soybean hulls (5 % FSBH, 10 % FSBH) as replacements for the basic diet. Each group contained 80 birds, divided into four pens with 20 birds per pen, and the trial lasted for 35 days.

Endogenous gliadin/glutenin fractions regulate the short/long-term retrogradation behavior of starch-gluten gels.

This study explored composite gels' structural properties and short/long-term retrogradation behavior by varying ratios of wheat starch to gluten and gliadin to glutenin. The results showed that as the proportion of gluten increased, the degree of order and crystalline conformation was lost, manifested by an increase in the gel network's porosity and protein aggregation. The dilution effect of gluten on starch and the water competition significantly reduced the viscosity and elasticity of the system, and the ratio of glu75-gli25 had the most significant impact on the viscoelasticity.

Long-term survival analysis after radical gastrectomy for Epstein-Barr virus-associated gastric cancer: A multicenter study.

Background: The prognosis of Epstein-Barr virus-associated gastric cancer (EBVaGC)needs to be validated by high-quality studies. This study aimed to assess the long-term survival of EBVaGC patients after radical gastrectomy using multicenter data to explore the potential value of EBV infection status as a prognostic predictor.

Methods: We analyzed the clinical data of patients with EBVaGC and Epstein-Barr virus-negative gastric cancer (EBVnGC) who underwent radical gastrectomy from January 2013 to July 2020.

Efficacy and safety of prone positioning in patients undergoing extracorporeal membrane oxygenation (ECMO): A systematic review and meta-analysis.

Background: Acute respiratory distress syndrome (ARDS) is a severe lung condition characterized by diffuse alveolar damage and hypoxemia. Venovenous extracorporeal membrane oxygenation (vv-ECMO) supports gas exchange and reduces ventilator-induced injury, while prone positioning (PP) improves oxygenation by optimizing ventilation-perfusion matching.

Methods: We conducted a systematic review and meta-analysis, following PRISMA guidelines, using MEDLINE, Embase, and the Cochrane Library.

The significance of slowly biodegradable COD on denitrification in the OAO process.

The capacity of particulate organic matter to act as a carbon source for denitrification is a significant concern in wastewater treatment facilities. The biodegradability of particulate matter is essential to its applicability. This research aims to ascertain the role of particulate organic matter in denitrification by classifying COD, conducting pre and post denitrification tests, and analyzing the oxygen utilization rate (OUR) profile of respiration.

Evaluating European countries' progress towards SDGs: Insights from parallel SBM DEA analysis of economic, healthcare, environmental, and educational efficiencies.

The Sustainable Development Goals (SDGs) of the United Nations aim to address the sustainable challenges continuously emerging in the world today. This study analyzes the progress of 27 European countries from 2015 to 2019 in achieving SDG Goal 3 (Good Health and Well-Being), Goal 4 (Quality Education), and Goal 8 (Decent Work and Economic Growth). The implementation of these three goals is interconnected.

Deciphering the promotion and inhibition of bicarbonate fertilization on microalgal activity and nutrient uptake from wastewater.

Microalgal bioremediation is a promising alternative for biological wastewater treatment but constrained by low microalgal activities. Here, bicarbonate fertilization was introduced to enhance microalgal wastewater treatment, with systematic investigations of its biphasic dose-dependent effects on microalgal activity and nutrient uptake. The results showed that moderate inorganic carbon (MIC, 0.

Preparation and characterization of Salecan β-glucan-based edible film loaded with lemon essential oil nanoemulsion: Effects on the preservation of chilled pork.

Chilled meat is highly prone to microbial spoilage, and edible films with antimicrobial properties offer a feasible solution. In this study, oil-in-water (O/W) nanoemulsions loaded with lemon essential oil (LEO) were developed. Nanoemulsification improved the antioxidant and antimicrobial activities of LEO.

Glycopeptide-mimetic carbon dots/graphene oxide mediated fluorescent-recovery sensor for detecting Salmonella typhimurium.

Food safety issues associated with Salmonella present serious health risks, making detection crucial for public health protection. This study develops an efficient strategy for the capture of Salmonella typhimurium (S. typhimurium) based on the affinity between glycopeptide-mimetic carbon dots (g-CDs) and the type I fimbriae of S.

Graphene oxide and in-situ carbon reinforced hydroxyapatite scaffolds via ultraviolet-curing 3D printing technology with high osteoinductivity for bone regeneration.

Ultraviolet photopolymerization additive manufacturing has been used to fabricate calcium phosphate (Ca-P) ceramic scaffolds for repairing bone defects, but it is still a challenge for 3D printed Ca-P scaffolds to simultaneously enhance the mechanical strength and osteoinductivity. Here, we successfully developed a high-performance hydroxyapatite (HA) scaffold containing in-situ carbon and graphene oxide (GO) by precisely regulating the degreasing and sintering atmosphere. The results indicated that the mechanical properties of HA scaffolds could be significantly improved by regulating the amount of in-situ carbon.

A patient-centric approach to neuro-recovery after acute brain injuries.

Background: Patients discharged after acute brain injuries require ongoing medical care to support recovery and treat secondary neurologic complications. Most therapeutic trials for interventions after acute brain injuries use measures of disability (i.e.

Fine particulate matter (PM) and the blood-testis-barrier: an and mechanistic study.

Background: Fine particulate matter (PM) is considered a major component of ambient particulate matter (PM). Exposure to PM was shown to be related to male reproductive system injury. Ferroptosis is regarded as an iron-dependent programmed cell death, that is associated with the pathological process.

Development of xanthone derivatives as effective broad-spectrum antimicrobials: Disrupting cell wall and inhibiting DNA synthesis.

Discovering potent antibiotics is of critical importance due to the substantial increases of microbial resistance. Xanthones are intriguing sources of antimicrobials, despite a scarcity of extensive investigations into their mechanisms of action. Here, we reported the development of a series of xanthone derivatives, among which compound displayed strong broad-spectrum antibacterial activity, weak hemolytic activity, and low cytotoxicity against mammalian cell lines, low frequencies of drug resistance, and potent in vivo efficacy in - or -induced murine corneal infection models.