Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential.

In the present era, noncoding RNAs (ncRNAs) have become a subject of considerable scientific interest, with peptides encoded by ncRNAs representing a particularly promising avenue of investigation. The identification of ncRNA-encoded peptides in human cancers is increasing. These peptides regulate cancer progression through multiple molecular mechanisms.

The clinical outcomes of anterior minimally invasive inverted PHILOS plate fixation for distal humeral shaft fractures.

Background: The unique anatomy and biomechanics of the distal humerus make distal humeral shaft fractures a significant challenge in orthopedic surgery. Conventional posterior surgical approaches are associated with risks such as iatrogenic radial nerve injury and increased soft tissue trauma.

Objective: This study aimed to assess the clinical efficacy of an inverted PHILOS plate using an anterior minimally invasive percutaneous approach for treating distal humeral shaft fractures.

Potential drug targets for ovarian cancer identified through Mendelian randomization and colocalization analysis.

Background: The existing drugs for ovarian cancer (OC) are unsatisfactory and thus new drug targets are urgently required. We conducted proteome-wide Mendelian randomization (MR) and colocalization analysis to pinpoint potential targets for OC.

Methods: Data on protein quantitative trait loci (pQTL) for 734 plasma proteins were obtained from large genome-proteome-wide association studies.

A meta-analysis on the incidence rate of depression in Chinese menopausal women.

Objective: To systematically evaluate the incidence rate of depressive symptoms in Chinese menopausal women.

Method: Six major English databases including PubMed, EBSCO, Scopus, Web of Science, X-MOL, Springer, and three Chinese databases including WanFang, CNKI, and VIP databases were retrieved to collect all observational studies on the morbidity of depression symptoms in Chinese menopausal women published as of May 10, 2024. Use the US Healthcare Research and Quality (AHRQ) tests to assess the quality of individual studies.

CSTF2-impeded innate αβ T cell infiltration and activation exacerbate immune evasion of pancreatic cancer.

Alternative cleavage and polyadenylation (APA) have gained increasing attention in cancer biology, yet its role in modulating anti-tumor immune response remains largely unexplored. Here, we identify the cleavage stimulation factor 2 (CSTF2), an APA-related gene, as a pivotal suppressor of anti-tumor immunity in pancreatic ductal adenocarcinoma (PDAC). CSTF2 promotes tumor development by inhibiting the infiltration and cytotoxic immune cell recruitment function of TCRαβCD4CD8NK1.

Organelle-like structural evolution of coacervate droplets induced by photopolymerization.

The dynamic study of coacervates in vitro contributes our understanding of phase separation mechanisms in cells due to complex intracellular physiology. However, current researches mainly involve the use of exogenous auxiliary agents to form multi-compartmental coacervates with short-term stability. Herein, we report the endogenous self-organizing of multi-component coacervates (HA/PDDA/BSA/DMAEMA) induced by a dynamic stimulation process of protein-mediated photopolymerization.

Genomic profiling of pediococcus acidilactici BCB1H and identification of its key features for Biotechnological innovation, food technology and medicine.

Lactic acid bacteria has been extensively used in food industry because of widespread properties and Pediococcus is among one of them. This study aims to conduct a comprehensive genomic analysis of Pediococcus acidilactici strain BCB1H to elucidate its genetic composition, functional elements, and potential biotechnological applications. The objectives include identifying key genomic features such as coding sequences, tRNA and rRNA genes, antibiotic resistance genes, and secondary metabolite biosynthetic gene clusters, which will highlight the adaptability and potential of P.

The effect of ketamine-assisted group therapy on treatment-resistant mental health conditions in firefighters: a prospective observational case series.

Objective: Firefighters display elevated risk for diagnoses of mental health illnesses. Psychedelic-assisted therapies show promise in the treatment of clinically challenging conditions. This observational case series analyzed data from firefighters with mental health diagnoses who participated in a 12-week ketamine-assisted group therapy treatment plan.

Associations of Antenatal Corticosteroids With Neurodevelopment in Children Aged 27-30 Months: A Population-Based Cohort Study.

Objective: To examine the associations of antenatal corticosteroid (ACS) exposure with neurodevelopment in early childhood, and how these vary with gestational age at birth.

Design: Population-based cohort study.

Setting: Scotland, UK.

An updated systematic review and meta-analysis on the efficacy of supine versus prone position for pediatric PCNL.

Background: The incidence of pediatric kidney stones is increasing with recurrence rates ranging from 35 to 50%. Supine percutaneous nephrolithotomy (PCNL) presents a viable alternative to the conventional prone position, offering specific benefits but also posing certain risks.

Objective: To update a previously published systematic review and meta-analysis comparing the efficacy of PCNL in the supine versus prone positions in children.

Extended state observer-based backstepping control for nonlinear systems under FDI attacks.

In this paper, a novel extended state observer-based backstepping control scheme is proposed for strict-feedback nonlinear systems with unmeasured states suffering from false data injection (FDI) attacks. An extended state observer is designed to achieve simultaneous online estimation of system states and FDI attacks. A secure output feedback tracking control scheme with an attack compensation method is proposed to reduce the influence of FDI attacks.

Validation of 2-dimensional ultrasound imaging protocols for measuring the masseter muscle.

Objective(s): To determine the most repeatable ultrasound imaging protocols for assessing the masseter muscle, evaluating repeatability across different scan locations, muscle contraction states, and operator positions.

Study Design: Ten adult volunteers underwent ultrasound scans, including three axial (superior/middle/inferior) and three longitudinal (anterior/middle/posterior) views on the left and right sides and in the relaxed and clenched states. Each subject was scanned twice, roughly 15 minutes apart.

Effectiveness and influencing factors of standardised training for nursing assistants: a cross-sectional study.

Objectives: To investigate the impact of standardised training on nursing assistants (NAs) and explore the factors influencing training effectiveness, specifically focusing on learning motivation and learning obstacles.

Design: A cross-sectional study was conducted from August 2022 to September 2022.

Setting: The study was conducted in Fujian Province, China.

[Primary exploration of stage I anastomosis and T-tube fistulation in laparoscopic local resection of duodenal tumors].

To discuss the feasibility and safety of stage I anastomosis and T-tube fistulation in laparoscopic local resection of duodenal tumors. A descriptive case series study was used to retrospectively analyze the clinical diagnosis and treatment data of 14 patients with duodenal tumors who successfully underwent laparoscopic local resection of duodenal tumors + phase I anastomosis + T-tube ostomy in the Guangdong Provincial Hospital of Chinese Medicine and the First Affiliated Hospital of Guangzhou University of Chinese Medicine from October 2021 to March 2024. The resection and reconstruction steps of laparoscopic local resection of duodenal tumor + phase I anastomosis + T-tube ostomy are as follows: (1) after the safe margin is clear, the duodenal tumor is completely removed in full thickness, and the specimen bag is taken out and sent to frozen section to determine the nature of the tumor and the negative margin; (2) Perforate the anterior duodenal wall below the tumor plane, place a 16# T tube, and fix it with laparoscopic purse string suture.

[Prevention and treatment strategies of anastomotic leakage in laparoscopic low anterior resection in locally advanced rectal cancer].

Anastomotic leakage is a common complication in laparoscopic rectal cancer surgery, which can significantly impact patient recovery. This issue becomes even more critical in the context of the widespread application of standardized and procedural neoadjuvant patterns, as well as the increasing feasibility of anal-preserving surgery for ultra-low rectal cancer. Therefore, strategies to reduce or prevent anastomotic leakage are of paramount importance.

[Impact of perineural invasion upon chemotherapy duration and survival benefit in stageⅢ colon cancer].

To investigate the prognostic impact of perineural invasion in patients with stageⅢ colon cancer and to clarify its guidance value for the duration of postoperative adjuvant chemotherapy. This study employed a retrospective cohort study method. It analyzed 426 patients with stageⅢ colon cancer who underwent radical surgery at Sun Yat-sen University Cancer Center and Longyan First Affiliated Hospital of Fujian Medical University, between April 2008 and June 2020.

[Prognostic factors and survival analysis in rectal cancer patients with poor response to neoadjuvant therapy].

To compare the impact of different treatment strategies on the survival outcomes in rectal cancer patients with poor response to neoadjuvant therapy, and to explore the survival-related influencing factors. A retrospective cohort study was conducted. Between January 2018 and November 2022, the clinical, pathological, and follow-up data of 106 rectal cancer patients who received neoadjuvant therapy and were evaluated as grade 4 or 5 based on the Magnetic Resonance Tumor Regression Grade (mrTRG) from the rectal cancer database at Peking Union Medical College Hospital were retrospectively collected.

[Research progress on hepatitis B combined with C and its treatment].

HBV/HCV dual infection is not uncommon, especially in highly endemic areas and among individuals at elevated risk of infection, because of the common transmission mode of hepatitis B virus (HBV) and hepatitis C virus (HCV) and may be underestimated due to the presence of occult HBV infection. HBV/HCV dual infection is associated with more rapid progression to advanced severe liver disease, severely increased fibrosis or cirrhosis, liver decompensation, and the development of hepatocellular carcinoma, thus requiring effective antiviral treatment. However, the intracellular interaction between HBV and HCV has not been fully elucidated at present.

Efficacy of the BATMAN Score in Predicting Functional Outcomes After Thrombectomy for Basilar Arterial Occlusion: A Frequentist and Bayesian Meta-Analysis.

Background: The Basilar Artery on Computed Tomography Angiography (BATMAN) score is a 10-point grading system assessing arterial opacification and thrombus burden in the posterior circulation. It predicts outcomes in endovascular thrombectomy, with lower scores reflecting poor opacification.

Purpose: This systematic review and meta-analysis evaluated the BATMAN score's efficacy in predicting 90-day functional outcomes after thrombectomy.

Production of p-anisaldehyde via whole-cell transformation using recombinant E. coli expressing trans-anethole oxygenase.

p-Anisaldehyde, a fragrance and flavour with important roles in food, cosmetics, and drug industries, is currently synthesized through chemical methods. Production of p-anisaldehyde by chemical oxidation of trans-anethole in industry gives rise to excessive by-products and adverse environmental impacts, whereas biological process would address such problems. Here, we presented a process of biotransformation of trans-anethole for production of p-anisaldehyde.

Aerobic exercise improves clearance of amyloid-β via the glymphatic system in a mouse model of Alzheimer's Disease.

Background: Aerobic exercise training can promote the recovery of learning and memory ability in Alzheimer's disease (AD), but the specific mechanism is still unclear. Previous studies have suggested that aquaporin-4 (AQP4)-mediated glymphatic system is an important way to clear β-amyloid (Aβ) in the brain, which is closely related to learning and memory impairment in AD. However, it remains unclear whether AQP4 regulates glymphatic clearance of Aβ which contributes to the beneficial effects of aerobic exercise in AD patients.