[The early diagnosis of neurodegenerative changes in multiple sclerosis and clinically isolated syndrome based on optical coherence tomography of the retina].

Aim: To study signs of neurodegeneration in the retina in multiple sclerosis.

Material And Methods: We studied the retinal nerve fiber layer (RNFL) in 265 (524 eyes) patients.

Results And Conclusion: We identified a reliable thinning of RNFL of both eyes in patients with relapsing-remitting multiple sclerosis (MS).

[Assessment of the risk of the transition of a monofocal clinically isolated syndrome to clinically definite multiple sclerosis].

We followed up 102 patients with a monofocal clinically isolated syndrome (CIS) during 8 years. Factors determining its transition to definite multiple sclerosis were singled out according to the data of anamnesis and MRI scans. Age of patients at the onset of CIS and the volume of demyelination measured by the first MRI were the most significant predictors of the transition of CIS to definite multiple sclerosis.

[Sociological research in Samara Oblast: a role of social organizations of patients in the improvement of quality of medical and social care].

Results of a sociological research studying characteristics of reintegration of people with multiple sclerosis (MS) in a society are presented. During the research, people with MS living in the territory of the Samara region and experts, representatives of a region profile medical community, have been interrogated. The analysis of medical and social factors influencing the process of rehabilitation of the target group of patients is given.