The effect of cultured autologous fibroblasts on longevity of cross-linked hyaluronic acid used as a filler.

Background: Various kinds of biomaterials are being used for soft tissue augmentation in plastic surgery. Organic molecules are usually absorbed in a short amount of time. Inorganic molecules stay in the body for a longer period of time, but are prone to cause various reactions; therefore, none of them are ideal filler substances.